{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:03:47Z","timestamp":1779710627149,"version":"3.53.1"},"posted":{"date-parts":[[2026,5,15]]},"group-title":"Public and Global Health","reference-count":14,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  We estimated the number needed to vaccinate (NNV) with an M72\/AS01\n                  <jats:sub>E<\/jats:sub>\n                  -like vaccine to prevent one tuberculosis case in U.S. high-risk groups. Targeted vaccination of\n                  <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                  \u2013infected persons yielded NNVs of 217 (persons with HIV) to 2,486 (U.S.-born), within the range of established adult vaccines.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Summary line<\/jats:title>\n                  <jats:p>\n                    Targeted vaccination of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    -infected high-risk persons with an M72\/AS01\n                    <jats:sub>E<\/jats:sub>\n                    -like vaccine could prevent one tuberculosis case per 217 (HIV) to 2,486 (U.S.-born) persons vaccinated, within the range of established adult vaccines.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.11.26352950","type":"posted-content","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:45:53Z","timestamp":1779075953000},"source":"Crossref","is-referenced-by-count":0,"title":["Number Needed to Vaccinate with a Novel Tuberculosis Vaccine to Prevent Tuberculosis in High-Risk Populations, United States"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-1092","authenticated-orcid":false,"given":"Jessica E.","family":"Rothman","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"},{"name":"Hubert Department of Global Health, Rollins School of Public Health, Emory University, 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