{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:06:57Z","timestamp":1778951217650,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,14]]},"group-title":"Cardiovascular Medicine","reference-count":23,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neighborhood social vulnerability may shape cardiovascular health (CVH), but its association with Life\u2019s Essential 8 (LE8), and whether changes in vulnerability track with changes in CVH during midlife, are unclear. We examined cross-sectional and longitudinal associations of the Social Vulnerability Index (SVI) with LE8 and assessed differences by SVI domain, LE8 component, race, and sex.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed CARDIA participants at Year 15 (Y15; 2000-2001; n = 3,168; mean age 40 years) and Year 30 (Y30; 2015-2016; n = 2,267; mean age 55 years). Residential addresses were geocoded and linked to 2000 and 2016 SVI. Participants were stratified by SVI quartiles. CVH scores were calculated from LE8 metrics (range 0-100; higher is better CVH), excluding sleep. Using multivariable linear regression adjusted for age, sex, race, and educational attainment, we estimated LE8 differences across SVI quartiles and associations of 15-year SVI change\/residential mobility with change in LE8. Cox models estimated incident CVD associations.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher SVI was associated with lower LE8 at both exams. Adjusted Q4 vs Q1 differences in overall LE8 were -5.34 points (95% CI, -6.90 to -3.78) at Y15 and -4.60 points (95% CI, -6.51 to -2.69) at Y30. Among the four SVI domains, SES and household characteristics drove most of the disparity in LE8 scores (Y30 Q4 vs. Q1: SES \u0394 = \u20136.98; household \u0394 = \u20136.56 points). Component-level differences across quartiles of SVI were largest for nicotine exposure at Y15 (-13.09 points) and physical activity at Y30 (-13.09 points). Changes in SVI and residential mobility were not significantly associated with change in LE8.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher social vulnerability was associated with significantly lower CVH. Socioeconomic and household factors, along with behavioral gaps in nicotine exposure and physical activity, may be key targets for community-level interventions to improve cardiovascular health equity.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.11.26352953","type":"posted-content","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:05:16Z","timestamp":1778774716000},"source":"Crossref","is-referenced-by-count":0,"title":["Higher Neighborhood Social Vulnerability is Associated with Lower Life\u2019s Essential 8 Cardiovascular Health Scores: the Coronary Artery Risk Development in Young Adults (CARDIA) Study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9661-6322","authenticated-orcid":false,"given":"James","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-9429","authenticated-orcid":false,"given":"Emily","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyanna","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia D.","family":"Juarez","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Population Science, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Kiefe","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-6397","authenticated-orcid":false,"given":"Kiarri N.","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1157-6614","authenticated-orcid":false,"given":"Hongyan","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-6110","authenticated-orcid":false,"given":"Donald","family":"Lloyd-Jones","sequence":"additional","affiliation":[{"name":"Framingham Center for Population and Prevention Science, Boston University Chobanian & Avedisian School of Medicine, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026051609150958000_2026.05.11.26352953v1.1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001078"},{"key":"2026051609150958000_2026.05.11.26352953v1.2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.122.060911"},{"key":"2026051609150958000_2026.05.11.26352953v1.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02824-8"},{"key":"2026051609150958000_2026.05.11.26352953v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2023.01.021"},{"key":"2026051609150958000_2026.05.11.26352953v1.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000228"},{"key":"2026051609150958000_2026.05.11.26352953v1.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319811"},{"key":"2026051609150958000_2026.05.11.26352953v1.7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029765"},{"key":"2026051609150958000_2026.05.11.26352953v1.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1802313"},{"key":"2026051609150958000_2026.05.11.26352953v1.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2023-000877"},{"key":"2026051609150958000_2026.05.11.26352953v1.10","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.8584"},{"key":"2026051609150958000_2026.05.11.26352953v1.11","unstructured":"Centers for Disease Control and Prevention\/Agency for Toxic Substances and Disease Registry. 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