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Disruption of this coordination is a hallmark of human neurodevelopmental disorders, yet mechanisms that synchronize transcriptional maturation across cell types remain poorly understood. Here, we identify \u03b4-catenin (\n                  <jats:italic>Ctnnd2<\/jats:italic>\n                  ), a component of adherens junctions, that links cell\u2013cell interactions to transcriptional regulation. Using single-nucleus and spatial transcriptomics, we show that \u03b4-catenin loss disrupts transcriptional maturation across neural cell types, particularly in astrocytes. \u03b4-catenin loss impairs acquisition of layer-specific astrocyte identities and prolongs ocular dominance plasticity, indicating impaired circuit stabilization. Mechanistically, we identify the BTB\/POZ transcription factor Zbtb20, which is enriched in glial cells, as a key regulator of this process. \u03b4-catenin loss increases Zbtb20 expression, redistributes its genome-wide binding, and dysregulates its target genes. Together, these findings support a model in which \u03b4-catenin regulates Zbtb20-dependent transcriptional programs to establish layer-specific astrocyte identities in coordination with developing cortical circuits.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Sejourne et al report that loss of the\n                    <jats:italic>adherens<\/jats:italic>\n                    junction protein \u03b4-catenin prolongs ocular dominance plasticity and disrupts astrocyte and oligodendrocyte transcriptional identity. The underlying mechanism seems to rely on the glia-enriched transcription factor Zbtb20, which is upregulated and redistributed upon \u03b4-catenin loss, resulting in altered expression of its target genes.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.12.724361","type":"posted-content","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:50:12Z","timestamp":1778680212000},"source":"Crossref","is-referenced-by-count":0,"title":["\u03b4-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20"],"prefix":"10.64898","author":[{"given":"Gabrielle","family":"S\u00e9journ\u00e9","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"},{"name":"Medical Scientist Training Program, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christabel X.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"},{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracie","family":"Manigault","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Richard","family":"Jane Ding","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn J.","family":"Hardin","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"},{"name":"Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA"},{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Baumert","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sakers","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"},{"name":"Howard Hughes Medical Institute, Duke University, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-0218","authenticated-orcid":false,"given":"Cagla","family":"Eroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026051609101116000_2026.05.12.724361v1.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh2602"},{"key":"2026051609101116000_2026.05.12.724361v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05377-7"},{"key":"2026051609101116000_2026.05.12.724361v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3586"},{"key":"2026051609101116000_2026.05.12.724361v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2151"},{"key":"2026051609101116000_2026.05.12.724361v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURON.2018.10.009"},{"issue":"5","key":"2026051609101116000_2026.05.12.724361v1.6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/wdev.192","article-title":"Building blocks of the cerebral cortex: from development to the dish","volume":"4","year":"2015","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"2026051609101116000_2026.05.12.724361v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.04.021"},{"key":"2026051609101116000_2026.05.12.724361v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0602-1"},{"key":"2026051609101116000_2026.05.12.724361v1.9","doi-asserted-by":"crossref","unstructured":"Farhy-Tselnicker, I. , et al., Activity-dependent modulation of synapse-regulating genes in astrocytes. 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