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Here, we developed an immunomodulatory encapsulated cell-based \u2018biologics factory\u2019 that overcomes mAb instability, immunogenicity, and the fibrotic foreign body response that have limited previous approaches, enabling continuous\n                  <jats:italic>in situ<\/jats:italic>\n                  production of therapeutic antibodies from a single administration. Screening chemically modified alginate biomaterials in immunocompetent mice identified a lead immunomodulatory alginate formulation that sustains stable serum titers of the HIV-neutralizing mAb 3BNC117 for one year. Single-cell RNA sequencing revealed that this formulation promotes a local anti-inflammatory, pro-resolving immune niche that attenuates fibrosis. The platform\u2019s versatility was demonstrated by production of thirteen diverse mAbs from an allogeneic cell chassis, with sustained\n                  <jats:italic>in vivo<\/jats:italic>\n                  delivery of a subset including ipilimumab, pembrolizumab, adalimumab, and PGT121. Integration into a retrievable macrodevice enabled on-demand therapeutic termination and re-implantation for dose-proportional tuning. In a non-human primates, subcutaneous implantation maintained stable ipilimumab titers for over six months with no detectable toxicity, anti-drug antibodies, or adverse events, and dose-dependent exposure was confirmed across a three-dose escalation. These results demonstrate a clinically translatable platform offering a practical strategy to replace frequent injections with single-administration therapy.\n                <\/jats:p>","DOI":"10.64898\/2026.05.19.726224","type":"posted-content","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:30:34Z","timestamp":1779420634000},"source":"Crossref","is-referenced-by-count":1,"title":["Once yearly cell-based therapy for sustained and dose tunable delivery of monoclonal antibodies"],"prefix":"10.64898","author":[{"given":"Cody","family":"Fell","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Guinn","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"},{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeshi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"DeBonis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chancellor","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Murungi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imaan","family":"Mohandessi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bednarz","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ardeshir","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Tulane National Biomedical Research Center, Covington, LA, USA"},{"name":"Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Haupt","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Tulane National Biomedical Research Center, Covington, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel I.","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Tulane National Biomedical Research Center, Covington, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy L.","family":"Lavine","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Seaman","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Igoshin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Ghanta","sequence":"additional","affiliation":[{"name":"Michael E. 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