{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:13:39Z","timestamp":1779963219726,"version":"3.53.1"},"posted":{"date-parts":[[2026,5,25]]},"group-title":"Developmental Biology","reference-count":99,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["P20GM103423"],"award-info":[{"award-number":["P20GM103423"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["P20GM104318"],"award-info":[{"award-number":["P20GM104318"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["P20GM144265"],"award-info":[{"award-number":["P20GM144265"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F31 EY032790-01"],"award-info":[{"award-number":["F31 EY032790-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30EY001765-45"],"award-info":[{"award-number":["P30EY001765-45"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32EY007143-24"],"award-info":[{"award-number":["T32EY007143-24"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01EY026580"],"award-info":[{"award-number":["R01EY026580"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006312","name":"Brightfocus Foundation","doi-asserted-by":"crossref","award":["G2020315"],"award-info":[{"award-number":["G2020315"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  In humans, retinal-neuron death, optic-nerve injuries, and associated neurodegenerative diseases, such as glaucoma and age-related macular degeneration, often lead to permanent vision loss. While the capacity for regeneration is low in the human nervous system, including the retina, some non-mammalian vertebrate species, including zebrafish, are capable of endogenous neuronal regeneration after injury. Unlike mammals, zebrafish do not form a scar that inhibits axonal and neuronal regeneration after injury. Rather, they harbor neural progenitor and stem-cell populations allowing regeneration of entire parts of the nervous system and restoration of tissue integrity and function. In the zebrafish retina, cycling neural progenitor cells of the ciliary marginal zone and quiescent resident neural stem cells (the latter of which are also called M\u00fcller glial cells) participate in neuronal regeneration following different types of injury. In this study, we report the identification of a novel, additional cellular source participating in neuronal regeneration of neurons in the zebrafish retina after genetic ablation of retinal ganglion cells. Before injury, these progenitor cells express molecular markers of neural-crest-cell and\/or fibroblast identity, such as\n                  <jats:italic>sox10<\/jats:italic>\n                  ,\n                  <jats:italic>pdgfrb<\/jats:italic>\n                  , and\n                  <jats:italic>eya2<\/jats:italic>\n                  , while after neuronal ablation they also express proneural factors including the\n                  <jats:italic>ascl1a<\/jats:italic>\n                  and\n                  <jats:italic>olig2<\/jats:italic>\n                  genes. Combining genetic ablation of neurons with photoconversion or Cre\/Lox-dependent genetic lineage tracing of\n                  <jats:italic>sox10<\/jats:italic>\n                  -expressing cells, we demonstrated that these cells can differentiate into post-mitotic retinal neurons in the ganglion cell layer (GCL) in the absence of cell proliferation. We also showed, surprisingly, that this progenitor population locally produces\n                  <jats:italic>insulin<\/jats:italic>\n                  mRNA, and that insulin signaling is involved in the accumulation of mesenchymal-derived neural progenitors in the GCL and in their subsequent transdifferentiation into RGCs. This work reveals an unexpected and novel cellular mechanism of transdifferentiation, dependent on a neural-crest-derived mesenchymal cell population, participating in neuronal regeneration in the zebrafish retina. The discovery of this plastic cell population could potentially lead to new strategies to promote the formation of new neurons in the mammalian retina.\n                <\/jats:p>","DOI":"10.64898\/2026.05.20.726251","type":"posted-content","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T18:00:16Z","timestamp":1779732016000},"source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal-derived neural progenitors underlie local\n                  <i>insulin<\/i>\n                  production and neuronal transdifferentiation during retina regeneration"],"prefix":"10.64898","author":[{"given":"Bidhi","family":"Diwedi","sequence":"first","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindita","family":"Neog","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissette","family":"Baanannou","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Das","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Menard","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Halluin","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexter","family":"Morse","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Emmerich","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, Maryland, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Thierer","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, Maryland, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Patnaude","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bonnet","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Graber","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-287X","authenticated-orcid":false,"given":"Jeff S.","family":"Mumm","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, Baltimore, Maryland, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-415X","authenticated-orcid":false,"given":"Romain","family":"Madelaine","sequence":"additional","affiliation":[{"name":"The MDI Biological Laboratory, Bar Harbor, Maine, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026052802451532000_2026.05.20.726251v1.1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.103222"},{"key":"2026052802451532000_2026.05.20.726251v1.2","doi-asserted-by":"publisher","DOI":"10.3892\/IJMM.2025.5504"},{"key":"2026052802451532000_2026.05.20.726251v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/S41572-021-00265-2"},{"key":"2026052802451532000_2026.05.20.726251v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-90120-8.00016-2"},{"key":"2026052802451532000_2026.05.20.726251v1.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"2026052802451532000_2026.05.20.726251v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.037"},{"key":"2026052802451532000_2026.05.20.726251v1.7","doi-asserted-by":"publisher","DOI":"10.1007\/S40610-017-0069-3"},{"key":"2026052802451532000_2026.05.20.726251v1.8","doi-asserted-by":"publisher","DOI":"10.1186\/S12886-020-01795-1"},{"key":"2026052802451532000_2026.05.20.726251v1.9","doi-asserted-by":"publisher","DOI":"10.1167\/IOVS.62.9.30"},{"key":"2026052802451532000_2026.05.20.726251v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/NCOMMS10472"},{"key":"2026052802451532000_2026.05.20.726251v1.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609583"},{"key":"2026052802451532000_2026.05.20.726251v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.05.1029"},{"key":"2026052802451532000_2026.05.20.726251v1.13","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000551"},{"key":"2026052802451532000_2026.05.20.726251v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/S44321-025-00209-3"},{"key":"2026052802451532000_2026.05.20.726251v1.15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.085852"},{"key":"2026052802451532000_2026.05.20.726251v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/85090"},{"key":"2026052802451532000_2026.05.20.726251v1.17","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.219028"},{"key":"2026052802451532000_2026.05.20.726251v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/nature23283"},{"key":"2026052802451532000_2026.05.20.726251v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510595112"},{"key":"2026052802451532000_2026.05.20.726251v1.20","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABQ7219"},{"key":"2026052802451532000_2026.05.20.726251v1.21","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122796"},{"key":"2026052802451532000_2026.05.20.726251v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3723"},{"key":"2026052802451532000_2026.05.20.726251v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.12.007"},{"key":"2026052802451532000_2026.05.20.726251v1.24","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22856"},{"key":"2026052802451532000_2026.05.20.726251v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.07.001"},{"key":"2026052802451532000_2026.05.20.726251v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.12.024"},{"key":"2026052802451532000_2026.05.20.726251v1.27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4853-07.2008"},{"key":"2026052802451532000_2026.05.20.726251v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2017.05.012"},{"key":"2026052802451532000_2026.05.20.726251v1.29","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3144"},{"key":"2026052802451532000_2026.05.20.726251v1.30","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.32319"},{"key":"2026052802451532000_2026.05.20.726251v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/stem.579"},{"key":"2026052802451532000_2026.05.20.726251v1.32","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091355"},{"key":"2026052802451532000_2026.05.20.726251v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2023.10.021"},{"key":"2026052802451532000_2026.05.20.726251v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109857"},{"key":"2026052802451532000_2026.05.20.726251v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01364-4"},{"key":"2026052802451532000_2026.05.20.726251v1.36","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.202754"},{"key":"2026052802451532000_2026.05.20.726251v1.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617721114"},{"key":"2026052802451532000_2026.05.20.726251v1.38","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab020"},{"key":"2026052802451532000_2026.05.20.726251v1.39","first-page":"425","volume":"12","author":"Treatment of Diabetes Mellitus by Pancreatic Extracts","year":"1922","journal-title":"Can. Med. Assoc. J"},{"key":"2026052802451532000_2026.05.20.726251v1.40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308690100"},{"key":"2026052802451532000_2026.05.20.726251v1.41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI.INSIGHT.135412"},{"key":"2026052802451532000_2026.05.20.726251v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/S42255-022-00728-0"},{"key":"2026052802451532000_2026.05.20.726251v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.024"},{"key":"2026052802451532000_2026.05.20.726251v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.016"},{"key":"2026052802451532000_2026.05.20.726251v1.45","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.47929"},{"key":"2026052802451532000_2026.05.20.726251v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.041"},{"key":"2026052802451532000_2026.05.20.726251v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/nature09669"},{"key":"2026052802451532000_2026.05.20.726251v1.48","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ADX5296"},{"key":"2026052802451532000_2026.05.20.726251v1.49","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.168294"},{"key":"2026052802451532000_2026.05.20.726251v1.50","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAQ0681"},{"key":"2026052802451532000_2026.05.20.726251v1.51","doi-asserted-by":"publisher","DOI":"10.1038\/nrn874"},{"key":"2026052802451532000_2026.05.20.726251v1.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.12.009"},{"key":"2026052802451532000_2026.05.20.726251v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-017-00143-0"},{"key":"2026052802451532000_2026.05.20.726251v1.54","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2020.00379"},{"key":"2026052802451532000_2026.05.20.726251v1.55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-5-12"},{"key":"2026052802451532000_2026.05.20.726251v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2022.11.002"},{"key":"2026052802451532000_2026.05.20.726251v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-023-32212-4"},{"key":"2026052802451532000_2026.05.20.726251v1.58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09387.2002"},{"key":"2026052802451532000_2026.05.20.726251v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.08.048"},{"key":"2026052802451532000_2026.05.20.726251v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112015"},{"key":"2026052802451532000_2026.05.20.726251v1.61","first-page":"20","article-title":"Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis","volume":"1","year":"2011","journal-title":"Curr. Cell. Biochem"},{"key":"2026052802451532000_2026.05.20.726251v1.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.068"},{"key":"2026052802451532000_2026.05.20.726251v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3723"},{"key":"2026052802451532000_2026.05.20.726251v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"2026052802451532000_2026.05.20.726251v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.045"},{"key":"2026052802451532000_2026.05.20.726251v1.66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313192110"},{"key":"2026052802451532000_2026.05.20.726251v1.67","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-7-30"},{"key":"2026052802451532000_2026.05.20.726251v1.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107220108"},{"key":"2026052802451532000_2026.05.20.726251v1.69","doi-asserted-by":"publisher","DOI":"10.1093\/JMCB\/MJAA046"},{"key":"2026052802451532000_2026.05.20.726251v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/SREP06043"},{"key":"2026052802451532000_2026.05.20.726251v1.71","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.147942"},{"key":"2026052802451532000_2026.05.20.726251v1.72","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120813"},{"key":"2026052802451532000_2026.05.20.726251v1.73","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10224"},{"key":"2026052802451532000_2026.05.20.726251v1.74","doi-asserted-by":"publisher","DOI":"10.1007\/s40139-017-0127-9"},{"key":"2026052802451532000_2026.05.20.726251v1.75","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-28"},{"key":"2026052802451532000_2026.05.20.726251v1.76","first-page":"57","article-title":"Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF\/FGFR\/MEK\/Erk dependent upregulation of Pax6","volume":"13","year":"2007","journal-title":"Mol. Vis"},{"key":"2026052802451532000_2026.05.20.726251v1.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.07.003"},{"key":"2026052802451532000_2026.05.20.726251v1.78","doi-asserted-by":"publisher","DOI":"10.1159\/000048710"},{"key":"2026052802451532000_2026.05.20.726251v1.79","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"2026052802451532000_2026.05.20.726251v1.80","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.050215"},{"key":"2026052802451532000_2026.05.20.726251v1.81","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD-2010-10-314120"},{"key":"2026052802451532000_2026.05.20.726251v1.82","doi-asserted-by":"publisher","DOI":"10.1242\/dev.132654"},{"key":"2026052802451532000_2026.05.20.726251v1.83","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.199640"},{"key":"2026052802451532000_2026.05.20.726251v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.04.005"},{"key":"2026052802451532000_2026.05.20.726251v1.85","doi-asserted-by":"publisher","DOI":"10.1242\/dev.137000"},{"key":"2026052802451532000_2026.05.20.726251v1.86","doi-asserted-by":"publisher","DOI":"10.1242\/dev.072587"},{"key":"2026052802451532000_2026.05.20.726251v1.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.018"},{"key":"2026052802451532000_2026.05.20.726251v1.88","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21343"},{"key":"2026052802451532000_2026.05.20.726251v1.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.10.004"},{"key":"2026052802451532000_2026.05.20.726251v1.90","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.21.4113"},{"key":"2026052802451532000_2026.05.20.726251v1.91","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.5.1087"},{"key":"2026052802451532000_2026.05.20.726251v1.92","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"2026052802451532000_2026.05.20.726251v1.93","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2859"},{"key":"2026052802451532000_2026.05.20.726251v1.94","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0414-6"},{"key":"2026052802451532000_2026.05.20.726251v1.95","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"2026052802451532000_2026.05.20.726251v1.96","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"2026052802451532000_2026.05.20.726251v1.97","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"2026052802451532000_2026.05.20.726251v1.98","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026052802451532000_2026.05.20.726251v1.99","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.05.20.726251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:45:25Z","timestamp":1779961525000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.05.20.726251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":99,"URL":"https:\/\/doi.org\/10.64898\/2026.05.20.726251","relation":{},"subject":[],"published":{"date-parts":[[2026,5,25]]},"subtype":"preprint"}}