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Staining with hematoxylin and eosin (H&amp;E), the lipophilic dye Oil red O, and anti-adipophilin antibodies established the presence of LLDs exceeding 10 \u00b5m in diameter in choroid plexus epithelial cells (CPECs). Manual annotation of H&amp;E stains from 105 cases revealed a significant association between age and the percentage of CPECs containing LLDs (reaching up to 69%) and involving LLDs in our largest annotated category (&gt;5 \u00b5m in diameter). The LLD association with age was replicated and extended to a total of 245 cases using a trained convolutional neural network, which further showed significant associations with body mass index at time of death (increasing with BMI), sex (higher in females &gt;65 years old), and a near-significant association with Alzheimer\u2019s Disease (lower in AD). Like HepG2 and derived hepatocytes, excess fatty acids in culture media readily induced LLDs and steatosis in human embryonic stem cell-derived CPECs. Akin to hepatocytes for the human body, we propose that CPECs store lipids for the human brain and become steatotic in the setting of excess adiposity.<\/jats:p>","DOI":"10.64898\/2026.05.21.725559","type":"posted-content","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T18:05:12Z","timestamp":1779818712000},"source":"Crossref","is-referenced-by-count":1,"title":["Inducible lipid storage and steatosis in the human choroid plexus associated with age and adiposity"],"prefix":"10.64898","author":[{"given":"N. 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