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The innate signals that regulate the generation of IgA remain poorly defined. Here, we identified TRIF and IL-1R1 as immune checkpoints for intestinal IgA production. In the absence of infection,\n                  <jats:italic>\n                    Trif\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                  <\/jats:italic>\n                  and\n                  <jats:italic>\n                    Il1r1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                  <\/jats:italic>\n                  mice exhibited markedly elevated stool IgA and IgA-bound commensals. We show that IL-1R1 restricts IgA class-switching in a B cell-intrinsic manner, while TRIF acts extrinsically of B cells and shapes the Peyer\u2019s patch microenvironment. Loss of either\n                  <jats:italic>Trif<\/jats:italic>\n                  or\n                  <jats:italic>Il1r1<\/jats:italic>\n                  enhanced retinoic acid metabolism and allowed premature Ccnd3 upregulation in naive B cells, favoring both IgA class-switching and differentiation into germinal center B cells. During oral vaccination, the absence or blockade of the TRIF\/IL-1R1 pathway increased antigen-specific IgA production without affecting seric antigen-specific IgG levels. These findings unveil novel and local signaling targets to promote robust antigen-specific mucosal immunity.\n                <\/jats:p>","DOI":"10.64898\/2026.05.22.725254","type":"posted-content","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:25:26Z","timestamp":1779859526000},"source":"Crossref","is-referenced-by-count":0,"title":["A regulatory TRIF\/IL-1R1 axis controls T-dependent IgA production in the intestines"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-5835","authenticated-orcid":false,"given":"Chi-Chang","family":"Sung","sequence":"first","affiliation":[{"name":"Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimat Gafar","family":"Badmus","sequence":"additional","affiliation":[{"name":"Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, 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