{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:57:15Z","timestamp":1781110635466,"version":"3.54.1"},"posted":{"date-parts":[[2026,6,1]]},"group-title":"Neurology","reference-count":30,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation","award":["SBE-2342847"],"award-info":[{"award-number":["SBE-2342847"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01NS13979575"],"award-info":[{"award-number":["U01NS13979575"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["S10OD025025"],"award-info":[{"award-number":["S10OD025025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["S10OD030220"],"award-info":[{"award-number":["S10OD030220"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["S10RR028821"],"award-info":[{"award-number":["S10RR028821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01DC004290"],"award-info":[{"award-number":["R01DC004290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Despite substantial interest in how neural systems recover over time after acute neurological events, there is a dearth of longitudinal assessment from minutes to months surrounding these events. We compared rare intraoperative recordings in three patients, obtained immediately before and after anterior temporal lobe resection during a semantic prediction task, with longitudinal source-localized electroencephalography (EEG) obtained 2-6 weeks before, and 2 and 6-14 months after surgery. Relative to controls (\n                  <jats:italic>n<\/jats:italic>\n                  = 20), task performance showed sustained impairment in the two left-hemisphere patients and delayed impact in the right-hemisphere patient. Consistent with theories on ipsilateral and contralateral hemisphere compensation, all patients exhibited bilateral EEG alterations in speech responses and effective connectivity that did not fully recover to pre-operative levels. Direct dataset comparisons of intrinsic neurophysiological biomarkers associated with timescales of processing (\n                  <jats:italic>\u03c4<\/jats:italic>\n                  <jats:sub>INT<\/jats:sub>\n                  ) and excitatory-inhibitory balance (aperiodic slope, \u03c7\n                  <jats:sub>SPEC<\/jats:sub>\n                  ) showed a striking months-long reduction in rapid neural timescales of processing and gradually increasing aperiodic slope (putatively reflecting increased cortical inhibition or reduced excitation) specifically in the ipsilateral hemisphere of all three patients. Amidst these neurophysiological alterations, semantic task performance did not return to pre-operative levels. These rare longitudinal data advance a mechanistic framework to non-invasively evaluate neurophysiological impact over multiple timeframes in other patient cohorts.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Significance statement<\/jats:title>\n                  <jats:p>We report rare longitudinal recordings obtained minutes to months before and after epilepsy surgery. Using state-of-the-art measures of neurophysiological biomarkers and network dynamics, we observed immediate disruption followed by consistent, longer-lasting alterations in neural excitability and temporal functionality.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.23.26353585","type":"posted-content","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:55:12Z","timestamp":1780354512000},"source":"Crossref","is-referenced-by-count":0,"title":["Immediate to longer-term neurophysiological impact of acute neural network disruption"],"prefix":"10.64898","author":[{"given":"Zsuzsanna","family":"Kocsis","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"},{"name":"Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Calmus","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithendar","family":"Kasa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-9487","authenticated-orcid":false,"given":"Joel I.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Rhone","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Deifelt-Streese","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bowren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"},{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-9838","authenticated-orcid":false,"given":"Peter N.","family":"Taylor","sequence":"additional","affiliation":[{"name":"CNNP Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK"},{"name":"UCL Institute of Neurology, Queen Square, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McCall E.","family":"Sarrett","sequence":"additional","affiliation":[{"name":"Duolingo, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inyong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"McMurray","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Science, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-4381","authenticated-orcid":false,"given":"Timothy D.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Matthew A.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4932-7907","authenticated-orcid":false,"given":"Christopher I.","family":"Petkov","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061009001235000_2026.05.23.26353585v2.1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18147"},{"key":"2026061009001235000_2026.05.23.26353585v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55704-x"},{"key":"2026061009001235000_2026.05.23.26353585v2.3","doi-asserted-by":"crossref","unstructured":"Tracy J , Pustina D , Doucet G , Osipowicz K. Seizure-Induced Neuroplasticity and Cognitive Network Reorganization in Epilepsy. In: Tracy J , Hampstead B , Satian K , eds. Cognitive Plasticity in Neurologic Disorders. Oxford University Press; 2015:29\u201360.","DOI":"10.1093\/med\/9780199965243.003.0002"},{"key":"2026061009001235000_2026.05.23.26353585v2.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq175"},{"key":"2026061009001235000_2026.05.23.26353585v2.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03433.x"},{"key":"2026061009001235000_2026.05.23.26353585v2.6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b2a48e"},{"key":"2026061009001235000_2026.05.23.26353585v2.7","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2010.47.1.17"},{"key":"2026061009001235000_2026.05.23.26353585v2.8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv365"},{"key":"2026061009001235000_2026.05.23.26353585v2.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu061"},{"key":"2026061009001235000_2026.05.23.26353585v2.10","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj161"},{"key":"2026061009001235000_2026.05.23.26353585v2.11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.173161"},{"key":"2026061009001235000_2026.05.23.26353585v2.12","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt105"},{"key":"2026061009001235000_2026.05.23.26353585v2.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.06.020"},{"key":"2026061009001235000_2026.05.23.26353585v2.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.12.025"},{"key":"2026061009001235000_2026.05.23.26353585v2.15","doi-asserted-by":"publisher","DOI":"10.1002\/epi.70104"},{"key":"2026061009001235000_2026.05.23.26353585v2.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42088-7"},{"key":"2026061009001235000_2026.05.23.26353585v2.17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.150"},{"key":"2026061009001235000_2026.05.23.26353585v2.18","doi-asserted-by":"crossref","first-page":"615626","DOI":"10.3389\/fncir.2020.615626","article-title":"A diversity of intrinsic timescales underlie neural computations","volume":"14","year":"2020","journal-title":"Frontiers in Neural Circuits"},{"key":"2026061009001235000_2026.05.23.26353585v2.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02218-z"},{"key":"2026061009001235000_2026.05.23.26353585v2.20","doi-asserted-by":"crossref","unstructured":"Kocsis Z , Jenison RL , Cope TE , et al. Immediate neural network impact and incomplete compensation after the loss of a semantic hub. Nature Communications. 2022; in press","DOI":"10.1038\/s41467-023-42088-7"},{"key":"2026061009001235000_2026.05.23.26353585v2.21","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.283"},{"key":"2026061009001235000_2026.05.23.26353585v2.22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu101"},{"key":"2026061009001235000_2026.05.23.26353585v2.23","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.91.040101"},{"key":"2026061009001235000_2026.05.23.26353585v2.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00744-x"},{"key":"2026061009001235000_2026.05.23.26353585v2.25","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0392"},{"key":"2026061009001235000_2026.05.23.26353585v2.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-025-00626-7"},{"key":"2026061009001235000_2026.05.23.26353585v2.27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt222"},{"key":"2026061009001235000_2026.05.23.26353585v2.28","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16489"},{"key":"2026061009001235000_2026.05.23.26353585v2.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2024.100139"},{"key":"2026061009001235000_2026.05.23.26353585v2.30","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00267"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.05.23.26353585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:00:21Z","timestamp":1781107221000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.05.23.26353585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":30,"URL":"https:\/\/doi.org\/10.64898\/2026.05.23.26353585","relation":{},"subject":[],"published":{"date-parts":[[2026,6,1]]},"subtype":"preprint"}}