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While monocytes and macrophages are thought to be important in MAS pathogenesis, their role remains poorly understood. We used bulk and single-cell RNA sequencing (RNA-Seq) on sorted monocytes from children with MAS and healthy controls to identify transcriptional changes during MAS. We defined a MAS signature in classical monocytes that correlated with ferritin and was elevated in monocytes from systemic lupus erythematosus and COVID-19 patients. We also identified a subset of classical monocytes with high levels of interferon-stimulated genes (ISGs) that expanded during MAS. Surprisingly, the transcriptional signature of these cells was driven by type I IFNs, rather than IFN\u03b3. Consistent with this finding, we detected increased levels of circulating IFN\u03b2 during MAS, suggesting that IFN\u03b2 plays an unrecognized role in driving MAS monocyte responses. We also identified a MAS-associated CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cell population with a distinctive transcriptional signature. We used cell-cell communication algorithms to predict increased immunoregulatory interactions between monocytes and T cells during MAS. Together, these results provide new evidence for a role for type I IFN during MAS and identify a unique CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cell population that may contribute to MAS pathophysiology.\n                <\/jats:p>","DOI":"10.64898\/2026.05.23.727321","type":"posted-content","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:30:13Z","timestamp":1779784213000},"source":"Crossref","is-referenced-by-count":1,"title":["Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8\n                  <sup>+<\/sup>\n                  T cells During Macrophage Activation Syndrome"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-6718","authenticated-orcid":false,"given":"Susan P.","family":"Canny","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, WA"},{"name":"Division of Rheumatology, Seattle Children\u2019s Hospital, Seattle, 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