{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:45:40Z","timestamp":1785422740543,"version":"3.56.0"},"posted":{"date-parts":[[2026,5,27]]},"group-title":"Neuroscience","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Stanford Alzheimer\u2019s Disease Research Center: National Institute on Aging","award":["P50AG047366"],"award-info":[{"award-number":["P50AG047366"]}]},{"name":"Stanford Alzheimer\u2019s Disease Research Center: National Institute on Aging","award":["P30AG066515"],"award-info":[{"award-number":["P30AG066515"]}]},{"award":["AG072255"],"award-info":[{"award-number":["AG072255"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AG057909"],"award-info":[{"award-number":["AG057909"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AG061155"],"award-info":[{"award-number":["AG061155"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AG044829"],"award-info":[{"award-number":["AG044829"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AG066206"],"award-info":[{"award-number":["AG066206"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AG044546"],"award-info":[{"award-number":["R01AG044546"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RF1AG053303"],"award-info":[{"award-number":["RF1AG053303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RF1AG058501"],"award-info":[{"award-number":["RF1AG058501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01AG058922"],"award-info":[{"award-number":["U01AG058922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P01AG003991"],"award-info":[{"award-number":["P01AG003991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RF1AG074007"],"award-info":[{"award-number":["RF1AG074007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Alzheimer\u2019s Association Zenith Fellows Award","award":["ZEN-22-848604"],"award-info":[{"award-number":["ZEN-22-848604"]}]},{"DOI":"10.13039\/100020048","name":"Milky Way Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020048","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stanford Graduate Fellowship"},{"name":"Stanford Translational Program in Aging Research","award":["T32AG0471"],"award-info":[{"award-number":["T32AG0471"]}]},{"DOI":"10.13039\/100020420","name":"Nan Fung Life Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020420","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,27]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>Neurodegenerative diseases are often accompanied by systemic comorbidities, including changes in bone health, but the molecular relationship between neurodegeneration, skeletal decline, and cellular senescence remains poorly understood. In this study, we investigated sex-specific changes in circulating bone- and senescence-related proteins across the spectrum of Alzheimer\u2019s disease(AD), Lewbody dementia(LB) and Parkinson\u2019s disease(PD). Plasma proteomic profiling was performed on samples from 408 participants deeply phenotyped for neurodegenerative diseases, followed by differential protein and pathway analyses. This study reveals sex-dependent alterations in bone and senescence-related circulating proteins in AD-related, PD and LB-related neurodegenerative diseases, providing insights into the complex relationship between neurodegeneration and bone health. Several candidate proteins were also associated with established plasma neurodegeneration biomarkers, particularly pTau181. Pathway analyses revealed shared mitochondrial and metabolic dysfunction across neurodegenerative diseases, with disease-specific features including vesicle trafficking disruption in AD and inflammatory-senescence pathways in LB, plus sex-divergent patterns in inflammatory signaling and bone-related pathways.<\/jats:p>","DOI":"10.64898\/2026.05.23.727339","type":"posted-content","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:05:42Z","timestamp":1779919542000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases"],"prefix":"10.64898","author":[{"given":"Siddharth","family":"Kaipa","sequence":"first","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Rama","family":"Krishna Meka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Moran-Losada","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihuai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Channappa","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-7593","authenticated-orcid":false,"given":"Hamilton Se-Hwee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod","family":"Rutledge","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-9096","authenticated-orcid":false,"given":"Michael","family":"Zeineh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Biomedical Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward N.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounica","family":"Bandela","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Biomedical Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana","family":"Raghuraman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Al-Rajhi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Akkiraju","sequence":"additional","affiliation":[{"name":"Department of Cognitive Sciences, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Neretti","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA"},{"name":"Center on the Biology of Aging, Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-4372","authenticated-orcid":false,"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MichaelP.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-0831","authenticated-orcid":false,"given":"Tony","family":"Wyss-Coray","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological sciences, Stanford University, Stanford, CA, USA"},{"name":"Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-2989","authenticated-orcid":false,"given":"Vidyani","family":"Suryadevara","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026053013051138000_2026.05.23.727339v1.1","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1002\/alz.13015","article-title":"Impact of Alzheimer\u2019s association support and engagement in the AD\/ADRD research community through the COVID-19 pandemic and beyond","volume":"19","year":"2023","journal-title":"Alzheimers. Dement"},{"key":"2026053013051138000_2026.05.23.727339v1.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-026-01745-3"},{"key":"2026053013051138000_2026.05.23.727339v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60240-2"},{"key":"2026053013051138000_2026.05.23.727339v1.4","doi-asserted-by":"crossref","first-page":"e70546","DOI":"10.1002\/alz.70546","article-title":"Multimorbidity in dementia: Current perspectives and future challenges","volume":"21","year":"2025","journal-title":"Alzheimers. Dement"},{"key":"2026053013051138000_2026.05.23.727339v1.5","doi-asserted-by":"publisher","DOI":"10.1002\/alz.089553"},{"key":"2026053013051138000_2026.05.23.727339v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01296-0"},{"key":"2026053013051138000_2026.05.23.727339v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"2026053013051138000_2026.05.23.727339v1.8","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2020.34.s1.09466"},{"key":"2026053013051138000_2026.05.23.727339v1.9","doi-asserted-by":"crossref","first-page":"e70097","DOI":"10.1002\/cph4.70097","article-title":"Presenilin L166P mutation, a model of familial Alzheimer\u2019s disease, leads to early onset bone loss","volume":"16","year":"2026","journal-title":"Compr. Physiol"},{"key":"2026053013051138000_2026.05.23.727339v1.10","first-page":"e12923","article-title":"Prevalence of falls and fractures in Alzheimer\u2019s patients compared to general population","volume":"13","year":"2021","journal-title":"Cureus"},{"key":"2026053013051138000_2026.05.23.727339v1.11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3233\/JAD-2009-1185","article-title":"Bone density and brain atrophy in early Alzheimer\u2019s disease","volume":"18","year":"2009","journal-title":"J. Alzheimers. Dis"},{"key":"2026053013051138000_2026.05.23.727339v1.12","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/oxfordjournals.aje.a009714","article-title":"Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: a community-based prospective study","volume":"148","year":"1998","journal-title":"Am. J. Epidemiol"},{"key":"2026053013051138000_2026.05.23.727339v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.03.033"},{"key":"2026053013051138000_2026.05.23.727339v1.14","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.1.107"},{"key":"2026053013051138000_2026.05.23.727339v1.15","doi-asserted-by":"crossref","first-page":"e12755","DOI":"10.1097\/MD.0000000000012755","article-title":"Bone mineral loss and cognitive impairment: The PRESENT project: The PRESENT project","volume":"97","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2026053013051138000_2026.05.23.727339v1.16","first-page":"e13772","article-title":"Alzheimer\u2019s disease and its association with bone health: A case-control study","volume":"13","year":"2021","journal-title":"Cureus"},{"key":"2026053013051138000_2026.05.23.727339v1.17","doi-asserted-by":"publisher","DOI":"10.1177\/2151458510389463"},{"key":"2026053013051138000_2026.05.23.727339v1.18","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1532-5415.1999.tb07436.x","article-title":"APOE 4 and hip fracture risk in a community-based study of older adults","volume":"47","year":"1999","journal-title":"J. Am. Geriatr. Soc"},{"key":"2026053013051138000_2026.05.23.727339v1.19","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm116"},{"key":"2026053013051138000_2026.05.23.727339v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35424-w"},{"key":"2026053013051138000_2026.05.23.727339v1.21","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1038\/s41591-023-02541-y","article-title":"Senolytic therapy for Alzheimer\u2019s disease","volume":"29","year":"2023","journal-title":"Nat. Med"},{"key":"2026053013051138000_2026.05.23.727339v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"2026053013051138000_2026.05.23.727339v1.23","doi-asserted-by":"crossref","unstructured":"Kumar, S. , Song, K. , Wang, J. , Baghel, M.S. , Wong, P. , Cao, X. , and Wan, M. (2024). Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis. Cell Biology.","DOI":"10.1101\/2024.08.15.608092"},{"key":"2026053013051138000_2026.05.23.727339v1.24","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900567RR"},{"key":"2026053013051138000_2026.05.23.727339v1.25","doi-asserted-by":"publisher","DOI":"10.1186\/ar2940"},{"key":"2026053013051138000_2026.05.23.727339v1.26","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s00256-024-04585-8","article-title":"Musculoskeletal imaging of senescence","volume":"53","year":"2024","journal-title":"Skeletal Radiol"},{"key":"2026053013051138000_2026.05.23.727339v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06802-1"},{"key":"2026053013051138000_2026.05.23.727339v1.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"2026053013051138000_2026.05.23.727339v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"2026053013051138000_2026.05.23.727339v1.30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"2026053013051138000_2026.05.23.727339v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21507"},{"key":"2026053013051138000_2026.05.23.727339v1.32","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"2026053013051138000_2026.05.23.727339v1.33","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"2026053013051138000_2026.05.23.727339v1.34","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"2026053013051138000_2026.05.23.727339v1.35","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/s41591-025-03831-3","article-title":"Disruption of the cerebrospinal fluid\u2013plasma protein balance in cognitive impairment and aging","volume":"31","year":"2025","journal-title":"Nat Med"},{"key":"2026053013051138000_2026.05.23.727339v1.36","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.22.25338569"},{"key":"2026053013051138000_2026.05.23.727339v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32552-1"},{"key":"2026053013051138000_2026.05.23.727339v1.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"2026053013051138000_2026.05.23.727339v1.39","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAD1025"},{"key":"2026053013051138000_2026.05.23.727339v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELS.2015.12.004"},{"key":"2026053013051138000_2026.05.23.727339v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.036"},{"key":"2026053013051138000_2026.05.23.727339v1.42","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s43587-023-00446-6","article-title":"Spatial mapping of cellular senescence: emerging challenges and opportunities","volume":"3","year":"2023","journal-title":"Nat. Aging"},{"key":"2026053013051138000_2026.05.23.727339v1.43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151081"},{"key":"2026053013051138000_2026.05.23.727339v1.44","doi-asserted-by":"publisher","DOI":"10.1159\/000229024"},{"key":"2026053013051138000_2026.05.23.727339v1.45","doi-asserted-by":"crossref","first-page":"e2458149","DOI":"10.1001\/jamanetworkopen.2024.58149","article-title":"Alzheimer disease blood biomarkers and cognition among individuals with diabetes and overweight or obesity","volume":"8","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"2026053013051138000_2026.05.23.727339v1.46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/jgs.16954","article-title":"Kidney function and cognitive decline in older adults: Examining the role of neurodegeneration","volume":"69","year":"2021","journal-title":"J. Am. Geriatr. Soc"},{"key":"2026053013051138000_2026.05.23.727339v1.47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/MCG.0000000000001714","article-title":"Alzheimer disease occurs more frequently in patients with inflammatory bowel disease: Insight from a nationwide study: Insight from a nationwide study","volume":"57","year":"2023","journal-title":"J. Clin. Gastroenterol"},{"key":"2026053013051138000_2026.05.23.727339v1.48","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13864"},{"key":"2026053013051138000_2026.05.23.727339v1.49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12906-019-2451-6","article-title":"Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"19","year":"2019","journal-title":"BMC Complement. Altern. Med"},{"key":"2026053013051138000_2026.05.23.727339v1.50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505259102"},{"key":"2026053013051138000_2026.05.23.727339v1.51","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-2011-101875","article-title":"Long-term treatment with lithium alleviates memory deficits and reduces amyloid-\u03b2 production in an aged Alzheimer\u2019s disease transgenic mouse model","volume":"24","year":"2011","journal-title":"J. Alzheimers. Dis"},{"key":"2026053013051138000_2026.05.23.727339v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04463-0"},{"key":"2026053013051138000_2026.05.23.727339v1.53","doi-asserted-by":"crossref","first-page":"e78022","DOI":"10.7554\/eLife.78022","article-title":"FSH-blocking therapeutic for osteoporosis","volume":"11","year":"2022","journal-title":"Elife"},{"key":"2026053013051138000_2026.05.23.727339v1.54","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00198-025-07611-0","article-title":"Association between osteoporosis and risk of dementia: a Korean women nationwide population-based cohort study","volume":"36","year":"2025","journal-title":"Osteoporos. Int"},{"key":"2026053013051138000_2026.05.23.727339v1.55","doi-asserted-by":"crossref","first-page":"e70503","DOI":"10.1002\/alz.70503","article-title":"Bisphosphonates and the risk of dementia in patients with osteoporosis or fragility fracture: A population-based study in Hong Kong","volume":"21","year":"2025","journal-title":"Alzheimers. Dement"},{"key":"2026053013051138000_2026.05.23.727339v1.56","first-page":"189","article-title":"A population-based study on the association between dementia and hip fractures in 85-year olds","volume":"8","year":"1996","journal-title":"Aging (Milano)"},{"key":"2026053013051138000_2026.05.23.727339v1.57","doi-asserted-by":"crossref","first-page":"afae167","DOI":"10.1093\/ageing\/afae167","article-title":"Osteoarthritis, osteoarthritis treatment and risk of incident dementia: a prospective cohort study based on UK Biobank","volume":"53","year":"2024","journal-title":"Age Ageing"},{"key":"2026053013051138000_2026.05.23.727339v1.58","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-022-00986-9"},{"key":"2026053013051138000_2026.05.23.727339v1.59","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41398-020-00954-8","article-title":"Neuroinflammation in dementia with Lewy bodies: a human post-mortem study","volume":"10","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"2026053013051138000_2026.05.23.727339v1.60","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.tins.2025.05.009","article-title":"What would it take to prove that a chronic infection is a causal agent in Alzheimer\u2019s disease?","volume":"48","year":"2025","journal-title":"Trends Neurosci"},{"key":"2026053013051138000_2026.05.23.727339v1.61","doi-asserted-by":"crossref","first-page":"6600944","DOI":"10.1155\/2022\/6600944","article-title":"Association of p53 with neurodegeneration in Parkinson\u2019s disease","volume":"2022","year":"2022","journal-title":"Parkinsons Dis"},{"key":"2026053013051138000_2026.05.23.727339v1.62","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00738-8"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.05.23.727339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T20:05:26Z","timestamp":1780171526000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.05.23.727339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":62,"URL":"https:\/\/doi.org\/10.64898\/2026.05.23.727339","relation":{},"subject":[],"published":{"date-parts":[[2026,5,27]]},"subtype":"preprint"}}