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When OCA is due to defects in melanosome ion transport, abnormally acidic conditions in the melanosome lumen inhibit tyrosinase, the critical pigment synthetic enzyme. Hence, a therapeutic approach that optimizes melanosome pH to increase pigment production presents a potential treatment for OCA and a method for decreasing skin cancer risk. Here, we report that reduction in sAC (\n                  <jats:italic>ADCY10<\/jats:italic>\n                  ) activity via naturally occurring human variants in\n                  <jats:italic>ADCY10<\/jats:italic>\n                  restores OCA pigmentation, and sAC inhibition increases melanin synthesis in both human and mouse OCA models. These findings demonstrate that targeting melanosome pH is an effective, previously untapped therapeutic strategy for OCA and elevated skin cancer risk.\n                <\/jats:p>","DOI":"10.64898\/2026.05.25.727673","type":"posted-content","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:10:14Z","timestamp":1780038614000},"source":"Crossref","is-referenced-by-count":0,"title":["Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinism"],"prefix":"10.64898","author":[{"given":"Samuel J","family":"Grondin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medical College, Cornell University, New York, New York, USA"},{"name":"Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"St. Pierre","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Weill 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