{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T21:00:35Z","timestamp":1780174835406,"version":"3.54.0"},"posted":{"date-parts":[[2026,5,28]]},"group-title":"Neuroscience","reference-count":70,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021790","name":"Fondation Recherche Alzheimer","doi-asserted-by":"crossref","award":["2025-P-01"],"award-info":[{"award-number":["2025-P-01"]}],"id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Thalamic nuclei support multiple cognitive processes, yet their integrity in biologically-defined Alzheimer\u2019s disease (AD) remains unknown.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHOD<\/jats:title>\n                  <jats:p>Amyloid status was determined using PET Centiloids &gt;24 in 1,327 participants from ADNI. Combined with clinical diagnosis, this yielded six groups: amyloid-negative or positive CN-MCI-dementia\/AD. Thalamic nuclei volumes were extracted from T1-weighted MRI using the HIPS-THOMAS algorithm.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Large volume reductions in the anteroventral, mediodorsal, and pulvinar nuclei were observed in amyloid-positive MCI and AD. Reduced volumes were also evident in amyloid-positive CN, supporting preclinical AD. Adding the anteroventral nucleus improved cognitive status classification in Random Forest analyses. A phenotypic model integrating thalamic nuclei clearly distinguished amyloid-positive groups from amyloid-negative CN and reclassified non-AD patients with 68% of amyloid-negative MCI subjects as CN-like, and 27% of amyloid-positive CN as MCI-like.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>Thalamic volumetry from conventional T1-weighted MRI enhances clinical insight into AD and provides a practical biomarker for disease intervention.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.26.728015","type":"posted-content","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T20:10:41Z","timestamp":1780171841000},"source":"Crossref","is-referenced-by-count":0,"title":["Thalamic nuclei insights into Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7711-3080","authenticated-orcid":false,"given":"Julie P.","family":"Vidal","sequence":"first","affiliation":[{"name":"Te Kura Mahi \u0101-Hirikapo | School of Psychology, Speech and Hearing, University of Canterbury. 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