{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:56:24Z","timestamp":1785426984505,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,2]]},"group-title":"Allergy and Immunology","reference-count":47,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011666","name":"Ehlers-Danlos Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011666","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RACER Award"],"award-info":[{"award-number":["RACER Award"]}],"id":[{"id":"https:\/\/ror.org\/03zzw1w08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RACER Plus Award"],"award-info":[{"award-number":["RACER Plus Award"]}],"id":[{"id":"https:\/\/ror.org\/03zzw1w08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["STARDOM"],"award-info":[{"award-number":["STARDOM"]}],"id":[{"id":"https:\/\/ror.org\/03zzw1w08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["GIM Award"],"award-info":[{"award-number":["GIM Award"]}],"id":[{"id":"https:\/\/ror.org\/03zzw1w08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Ralph E. 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The goal of this study was to develop a novel MC score based on 11 self-reported MC-related conditions with clinical and research utility to better understand MC symptoms in hEDS and HSD patients.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    From November 1, 2019, to June 13, 2025, patients (\n                    <jats:italic>n<\/jats:italic>\n                    =2,141) filled out an Intake Questionnaire at the Mayo Clinic Florida EDS Clinic that included 11 self-reported questions related to categories of MC-related conditions for a MC score ranging from 0\/11 to 11\/11. Based on the MC score distribution in hEDS and HSD patients, a MC score of 0-1 was considered a low MC score and \u22655 was considered a high MC score. Symptoms\/comorbidities were compared between patients with high vs. low MC scores.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    From the 2,141 hEDS\/HSD patients, 535 (25.0%) had a MC score \u22655 (Hi MC). MCAS-specific symptoms such as nausea and vomiting were reported more often in hEDS\/HSD patients with a high vs. low MC score (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.0001). Random clinical blood tryptase and urinary MC markers were not elevated in patients with high MC scores (\n                    <jats:italic>n<\/jats:italic>\n                    =50\/group), although high MC scores were found to significantly reduce urinary creatinine levels indicating that the protein used to normalize data was affected by MC activity. In contrast, random blood IgE, tryptase and major basic protein (MBP) by ELISA were increased in patients with high MC scores (e.g., IgE hEDS\n                    <jats:italic>p<\/jats:italic>\n                    =0.0004, HSD\n                    <jats:italic>p<\/jats:italic>\n                    =0.003). Of note, the percentage of patients reporting abuse or post-traumatic stress disorder was nearly doubled in patients with high vs. low MC scores (Abuse and PTSD: hEDS\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001; HSD\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). Overall, 109\/135 (80.7%) in hEDS and 129\/135 (95.6%) in HSD reported more symptoms\/comorbidities if they had a high MC score.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found that hEDS\/HSD patients with high MC scores self-reported more widespread symptoms\/comorbidities and higher MC-related blood markers than patients with low MC scores indicating the utility of this tool to evaluate the level of widespread MC activity in hEDS, HSD and other patients.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.31.26354552","type":"posted-content","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:45:21Z","timestamp":1780461921000},"source":"Crossref","is-referenced-by-count":0,"title":["Mast cell score associates with wide-spread mast cell symptoms and comorbidities in patients with hEDS and HSD"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8678-5831","authenticated-orcid":false,"given":"Frances C.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA"},{"name":"Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2129-4647","authenticated-orcid":false,"given":"Derek J.","family":"Zangerle","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4830-7580","authenticated-orcid":false,"given":"Lincoln E.","family":"Rozen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, 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Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1677-7988","authenticated-orcid":false,"given":"Charwan","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max W.","family":"Strandes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9802-1455","authenticated-orcid":false,"given":"Alayna M.","family":"Puls","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4924-8197","authenticated-orcid":false,"given":"Cameron 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