{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:03:13Z","timestamp":1780646593175,"version":"3.54.1"},"posted":{"date-parts":[[2026,6,2]]},"group-title":"Neurology","reference-count":66,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Aging, USA","award":["R56AG075744"],"award-info":[{"award-number":["R56AG075744"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    Alzheimer\u2019s disease and related dementias (AD\/ADRD) pathology begin decades before diagnosis, yet scalable risk detection infrastructures for midlife adults remain limited. The\n                    <jats:italic>Biomarker Evaluation of Young Onset Dementia from Diverse Populations<\/jats:italic>\n                    (BEYONDD; R56AG075744) pilot study was designed to address this gap through a decentralized, community-engaged research (CER) model for neurodegenerative risk detection in midlife adults with subjective cognitive or behavioral complaints (sCBC).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional pilot assessed the feasibility of CER-based digital recruitment and participant completion of remotely-acquired screening, cognitive, clinical, and phlebotomy assessments with support of Community Research Navigators (CRNs). Feasibility was evaluated using digital recruitment metrics, yield, retention, and geographic reach.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Our approach generated 1.8+ million advertisement impressions, 161,100 clicks, and 4,089 web-registrants. 2,117 individuals completed the online screener, exceeding the prespecified screening goal by 141%. We enrolled a multi-ethnic, midlife cohort of 579 participants (\n                    <jats:italic>\n                      M\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    =51.6[6.5]; 75% female; 44% Latinx, 31% non-Latinx Black-American, and 26% all other race\/ethnicities), exceeding the enrollment goal by 290%, and 476 participants completed the remote protocol (82% retention). Participants were recruited from 49 U.S. states, Puerto Rico, Australia, and Canada. CRN engagement was concentrated during study stage transitions.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>BEYONDD\u2019s decentralized, CER-based screening infrastructure demonstrated wide geographic reach, strong early-stage engagement, and efficient recruitment among diverse midlife adults. These findings support the feasibility of scalable CER-based digital recruitment for decentralized early detection initiatives and AD\/ADRD trials.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.01.26354636","type":"posted-content","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:50:14Z","timestamp":1780462214000},"source":"Crossref","is-referenced-by-count":0,"title":["The BEYONDD Pilot Study: A Decentralized Community-Engaged Research Framework for Multimodal Characterization of Neurodegenerative Risk in a Multi-Ethnic, Midlife Cohort with Subjective Cognitive or Behavioral Complaints"],"prefix":"10.64898","author":[{"given":"Monica","family":"Rivera-Mindt","sequence":"first","affiliation":[{"name":"Department of Psychology, Fordham University, New York, NY, USA"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah 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