{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:31:05Z","timestamp":1785403865265,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,4]]},"group-title":"Neuroscience","reference-count":91,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["F32-AA032173 to C.A."],"award-info":[{"award-number":["F32-AA032173 to C.A."]}],"id":[{"id":"https:\/\/ror.org\/02jzrsm59","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01-AA030594 to R.H."],"award-info":[{"award-number":["R01-AA030594 to R.H."]}],"id":[{"id":"https:\/\/ror.org\/02jzrsm59","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R00-AA027750 to M.B."],"award-info":[{"award-number":["R00-AA027750 to M.B."]}],"id":[{"id":"https:\/\/ror.org\/02jzrsm59","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"crossref","award":["T32-DA055569 to C.A. and M.M."],"award-info":[{"award-number":["T32-DA055569 to C.A. and M.M."]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"award":["NSF-GRFP to N.C.B"],"award-info":[{"award-number":["NSF-GRFP to N.C.B"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Rutgers Presidential Postdoctoral Fellowship","award":["awarded to C.A."],"award-info":[{"award-number":["awarded to C.A."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The dorsolateral striatum (DLS) is a key site for coordinating the alcohol-induced stimulant response, a behavioral marker predictive of future alcohol use disorder. Although ethanol (EtOH) affects all brain cells, little is known about the contribution of non-neuronal DLS cell types to EtOH-induced stimulation.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used ex vivo two photon calcium imaging, in vivo fiber photometry of astrocyte and neuronal GCaMP, and astrocyte-specific manipulations in mice to determine DLS astrocyte contributions to EtOH-induced stimulation and voluntary EtOH drinking behavior. Using fiber photometry of GRAB-ACh sensors and cell-type specific chemogenetics, we also assessed the role of cholinergic signaling in observed astrocyte EtOH effects.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>As expected, intraperitoneal EtOH injections (0.5-2g\/kg) evoked a stimulant response, evidenced by increased locomotion compared to saline. In parallel, EtOH dose-dependently decreased astrocyte calcium activity but had minimal effects on direct and indirect pathway neuronal activity. Mimicking this reduction with astrocyte-specific expression of CalEX, a calcium extruding pump, facilitated EtOH stimulation compared to mice expressing a control fluorophore. Hence, EtOH-induced suppression of DLS astrocyte activity contributes to stimulation. Astrocyte calcium signaling is a well-known target of neuromodulation. Fiber photometry recordings of extracellular acetylcholine (ACh) levels via GRAB-ACh imaging showed inhibition of ACh release by acute EtOH. We virally expressed the excitatory chemogenetic actuator hM3Dq in striatal cholinergic interneurons to assess whether artificially increasing ACh release blocks EtOH-induced inhibition of astrocytic calcium activity. Despite facilitating ACh release, this manipulation did not impact astrocyte calcium activity under control (saline) or EtOH conditions. Together, this work identifies DLS astrocytes as key contributors to EtOH-induced stimulation and highlights the importance of considering astrocyte-neuron interactions in evaluating alcohol effects.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.01.729412","type":"posted-content","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:15:13Z","timestamp":1780607713000},"source":"Crossref","is-referenced-by-count":1,"title":["Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-4600","authenticated-orcid":false,"given":"Cherish","family":"Ardinger","sequence":"first","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3282-4043","authenticated-orcid":false,"given":"Anagha","family":"Kalelkar","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-986X","authenticated-orcid":false,"given":"Maxwell","family":"Madden","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Gunda","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1320-7106","authenticated-orcid":false,"given":"Arnav","family":"Patel","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Xanthos","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5343-4804","authenticated-orcid":false,"given":"Mariam","family":"Mahboob","sequence":"additional","affiliation":[{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"},{"name":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Health New Jersey Medical School, Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2076-3363","authenticated-orcid":false,"given":"Ali","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"},{"name":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Health New Jersey Medical School, Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-8990","authenticated-orcid":false,"given":"Nancy","family":"Collie-Beard","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-032X","authenticated-orcid":false,"given":"Miriam","family":"Bocarsly","sequence":"additional","affiliation":[{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"},{"name":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Health New Jersey Medical School, Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-9966","authenticated-orcid":false,"given":"Rafiq","family":"Huda","sequence":"additional","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 USA"},{"name":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026060612001057000_2026.06.01.729412v1.1","doi-asserted-by":"crossref","unstructured":"Stok\u0142osa, I. , et al., Medications for the Treatment of Alcohol Dependence-Current State of Knowledge and Future Perspectives from a Public Health Perspective. Int J Environ Res Public Health, 2023. 20(3).","DOI":"10.3390\/ijerph20031870"},{"key":"2026060612001057000_2026.06.01.729412v1.2","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13168"},{"key":"2026060612001057000_2026.06.01.729412v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/369744a0"},{"key":"2026060612001057000_2026.06.01.729412v1.4","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002334"},{"key":"2026060612001057000_2026.06.01.729412v1.5","doi-asserted-by":"crossref","unstructured":"Nowacka, A. , M. \u015aniegocki , and E.A. Zi\u00f3\u0142kowska , Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling. Cells, 2025. 14(21).","DOI":"10.3390\/cells14211709"},{"key":"2026060612001057000_2026.06.01.729412v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01349-6"},{"key":"2026060612001057000_2026.06.01.729412v1.7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuroscience.2015.02.036","article-title":"Lateral regulation of synaptic transmission by astrocytes","volume":"323","year":"2016","journal-title":"Neuroscience"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.8","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1038\/s41467-020-17536-3","article-title":"Astrocytes modulate sensory-evoked neuronal network activity","volume":"11","year":"2020","journal-title":"Nature Communications"},{"key":"2026060612001057000_2026.06.01.729412v1.9","doi-asserted-by":"crossref","first-page":"1205544","DOI":"10.3389\/fnetp.2023.1205544","article-title":"Astrocytic modulation of neuronal signalling","volume":"3","year":"2023","journal-title":"Front Netw Physiol"},{"key":"2026060612001057000_2026.06.01.729412v1.10","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24178"},{"key":"2026060612001057000_2026.06.01.729412v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0721-0"},{"key":"2026060612001057000_2026.06.01.729412v1.12","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24841"},{"key":"2026060612001057000_2026.06.01.729412v1.13","doi-asserted-by":"crossref","first-page":"108272","DOI":"10.1016\/j.neuropharm.2020.108272","article-title":"Astrocyte modulation of extinction impairments in ethanol-dependent female mice","volume":"179","year":"2020","journal-title":"Neuropharmacology"},{"key":"2026060612001057000_2026.06.01.729412v1.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000374-199812000-00004"},{"key":"2026060612001057000_2026.06.01.729412v1.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02611.x"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1530-0277.2003.tb02719.x","article-title":"Behavioral undercontrol and subjective stimulant and sedative effects of alcohol intoxication: independent predictors of drinking habits?","volume":"27","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"2026060612001057000_2026.06.01.729412v1.17","unstructured":"Gmel, G. , et al., Association of anticipated stimulant and sedative effects of alcohol with future heavy drinking in a large Swiss cohort study of young men. Journal of Studies on Alcohol and Drugs. 0(ja): p. jsad.25-00189."},{"key":"2026060612001057000_2026.06.01.729412v1.18","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.26"},{"key":"2026060612001057000_2026.06.01.729412v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.001"},{"issue":"6","key":"2026060612001057000_2026.06.01.729412v1.20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1176\/appi.ajp.2020.20030247","article-title":"Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder","volume":"178","year":"2021","journal-title":"Am J Psychiatry"},{"issue":"3","key":"2026060612001057000_2026.06.01.729412v1.21","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1192\/bjo.2019.18","article-title":"The role of alcohol response phenotypes in the risk for alcohol use disorder","volume":"5","year":"2019","journal-title":"BJPsych Open"},{"key":"2026060612001057000_2026.06.01.729412v1.22","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.94.4.469"},{"key":"2026060612001057000_2026.06.01.729412v1.23","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.108.3.383"},{"issue":"5","key":"2026060612001057000_2026.06.01.729412v1.24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1037\/pha0000792","article-title":"Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task","volume":"33","year":"2025","journal-title":"Experimental and Clinical Psychopharmacology"},{"issue":"5","key":"2026060612001057000_2026.06.01.729412v1.25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.celrep.2019.09.059","article-title":"A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors","volume":"29","year":"2019","journal-title":"Cell Reports"},{"key":"2026060612001057000_2026.06.01.729412v1.26","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100699"},{"key":"2026060612001057000_2026.06.01.729412v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00378-0"},{"issue":"2","key":"2026060612001057000_2026.06.01.729412v1.28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00213-013-3151-4","article-title":"Determining the heritability of ethanol-induced locomotor sensitization in mice using short-term behavioral selection","volume":"230","year":"2013","journal-title":"Psychopharmacology (Berl"},{"key":"2026060612001057000_2026.06.01.729412v1.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1984.tb05707.x"},{"issue":"13","key":"2026060612001057000_2026.06.01.729412v1.30","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/s41386-018-0166-x","article-title":"Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers","volume":"43","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2026060612001057000_2026.06.01.729412v1.31","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007778"},{"key":"2026060612001057000_2026.06.01.729412v1.32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3709-06.2007"},{"key":"2026060612001057000_2026.06.01.729412v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0189-2"},{"key":"2026060612001057000_2026.06.01.729412v1.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19475-5"},{"key":"2026060612001057000_2026.06.01.729412v1.35","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20001001)41:2<123::AID-CYTO7>3.0.CO;2-1"},{"key":"2026060612001057000_2026.06.01.729412v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.64"},{"key":"2026060612001057000_2026.06.01.729412v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91000-0"},{"key":"2026060612001057000_2026.06.01.729412v1.38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001259"},{"key":"2026060612001057000_2026.06.01.729412v1.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2023.109800"},{"issue":"6","key":"2026060612001057000_2026.06.01.729412v1.40","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/glia.24679","article-title":"Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice","volume":"73","year":"2025","journal-title":"Glia"},{"issue":"7","key":"2026060612001057000_2026.06.01.729412v1.41","doi-asserted-by":"crossref","first-page":"111228","DOI":"10.1016\/j.celrep.2022.111228","article-title":"Striatonigrostriatal circuit architecture for disinhibition of dopamine signaling","volume":"40","year":"2022","journal-title":"Cell Rep"},{"key":"2026060612001057000_2026.06.01.729412v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0209-y"},{"key":"2026060612001057000_2026.06.01.729412v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.015"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.44","doi-asserted-by":"crossref","first-page":"7819","DOI":"10.1038\/s41467-025-63131-9","article-title":"Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behavior","volume":"16","year":"2025","journal-title":"Nature Communications"},{"key":"2026060612001057000_2026.06.01.729412v1.45","doi-asserted-by":"crossref","unstructured":"Bukalo, O. , et al., Astrocytes enable amygdala neural representations supporting memory. Nature, 2026.","DOI":"10.1038\/s41586-025-10068-0"},{"key":"2026060612001057000_2026.06.01.729412v1.46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0085-21.2021"},{"key":"2026060612001057000_2026.06.01.729412v1.47","doi-asserted-by":"crossref","first-page":"110320","DOI":"10.1016\/j.neuropharm.2025.110320","article-title":"In vivo calcium extrusion from accumbal astrocytes reduces anxiety-like behaviors but increases compulsive-like responses and compulsive ethanol drinking in mice","volume":"268","year":"2025","journal-title":"Neuropharmacology"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.48","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-021-23674-z","article-title":"Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice","volume":"12","year":"2021","journal-title":"Nat Commun"},{"key":"2026060612001057000_2026.06.01.729412v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.02.013"},{"key":"2026060612001057000_2026.06.01.729412v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.037"},{"key":"2026060612001057000_2026.06.01.729412v1.51","doi-asserted-by":"crossref","unstructured":"Huang, Z. , et al., Dynamic responses of striatal cholinergic interneurons control behavioral flexibility. Science Advances, 2024. 10(51): p. eadn2446.","DOI":"10.1126\/sciadv.adn2446"},{"issue":"3","key":"2026060612001057000_2026.06.01.729412v1.52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0091-3057(87)90343-1","article-title":"Stimulatory effects of ethanol in C57BL\/6 mice","volume":"27","year":"1987","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"2026060612001057000_2026.06.01.729412v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90371-6"},{"key":"2026060612001057000_2026.06.01.729412v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.056"},{"issue":"4","key":"2026060612001057000_2026.06.01.729412v1.55","doi-asserted-by":"crossref","first-page":"e70054","DOI":"10.1111\/jnc.70054","article-title":"The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators","volume":"169","year":"2025","journal-title":"Journal of Neurochemistry"},{"key":"2026060612001057000_2026.06.01.729412v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00068-8"},{"key":"2026060612001057000_2026.06.01.729412v1.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.004"},{"key":"2026060612001057000_2026.06.01.729412v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.019"},{"key":"2026060612001057000_2026.06.01.729412v1.59","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, R.C. , et al., Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors. bioRxiv, 2024.","DOI":"10.1101\/2024.11.23.624963"},{"key":"2026060612001057000_2026.06.01.729412v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.03.001"},{"key":"2026060612001057000_2026.06.01.729412v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90202-9"},{"key":"2026060612001057000_2026.06.01.729412v1.62","doi-asserted-by":"crossref","unstructured":"Stedehouder, J. , et al., Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes. bioRxiv, 2024: p. 2024.05.15.594341.","DOI":"10.17504\/protocols.io.dm6gp3k25vzp\/v1"},{"key":"2026060612001057000_2026.06.01.729412v1.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110706"},{"issue":"4","key":"2026060612001057000_2026.06.01.729412v1.64","doi-asserted-by":"crossref","first-page":"zqad019","DOI":"10.1093\/function\/zqad019","article-title":"Dissociation Between Neuronal and Astrocytic Calcium Activity in Response to Locomotion in Mice","volume":"4","year":"2023","journal-title":"Function (Oxf"},{"key":"2026060612001057000_2026.06.01.729412v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.003"},{"key":"2026060612001057000_2026.06.01.729412v1.66","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01284-w"},{"key":"2026060612001057000_2026.06.01.729412v1.67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75055"},{"issue":"3","key":"2026060612001057000_2026.06.01.729412v1.68","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1530-0277.2008.00854.x","article-title":"Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists","volume":"33","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"2026060612001057000_2026.06.01.729412v1.69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01520.x"},{"key":"2026060612001057000_2026.06.01.729412v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/nn1579"},{"key":"2026060612001057000_2026.06.01.729412v1.71","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.230"},{"key":"2026060612001057000_2026.06.01.729412v1.72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308198110"},{"key":"2026060612001057000_2026.06.01.729412v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.110"},{"key":"2026060612001057000_2026.06.01.729412v1.74","doi-asserted-by":"crossref","unstructured":"Hwang, S.N. , et al., Astrocytic Regulation of Neural Circuits Underlying Behaviors. Cells, 2021. 10(2).","DOI":"10.3390\/cells10020296"},{"issue":"9","key":"2026060612001057000_2026.06.01.729412v1.75","doi-asserted-by":"crossref","first-page":"116173","DOI":"10.1016\/j.celrep.2025.116173","article-title":"Astrocytes in the medial entorhinal cortex are required for spatial exploration","volume":"44","year":"2025","journal-title":"Cell Rep"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.76","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1021\/cn500278b","article-title":"Temporal profiles dissociate regional extracellular ethanol versus dopamine concentrations","volume":"6","year":"2015","journal-title":"ACS Chem Neurosci"},{"key":"2026060612001057000_2026.06.01.729412v1.77","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp6301"},{"key":"2026060612001057000_2026.06.01.729412v1.78","doi-asserted-by":"crossref","unstructured":"Hansson, E. and L. R\u00f6nnb\u00e4ck , Astrocytic receptors and second messenger systems , in Advances in Molecular and Cell Biology. 2003, Elsevier. p. 475\u2013501.","DOI":"10.1016\/S1569-2558(03)31021-5"},{"key":"2026060612001057000_2026.06.01.729412v1.79","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12436"},{"key":"2026060612001057000_2026.06.01.729412v1.80","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440080106"},{"issue":"12","key":"2026060612001057000_2026.06.01.729412v1.81","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.biopsych.2022.04.019","article-title":"Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M1 Muscarinic Receptor","volume":"92","year":"2022","journal-title":"Biological Psychiatry"},{"key":"2026060612001057000_2026.06.01.729412v1.82","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02443.2002"},{"key":"2026060612001057000_2026.06.01.729412v1.83","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5289-11.2011"},{"key":"2026060612001057000_2026.06.01.729412v1.84","doi-asserted-by":"publisher","DOI":"10.1126\/science.8023166"},{"key":"2026060612001057000_2026.06.01.729412v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90598-9"},{"key":"2026060612001057000_2026.06.01.729412v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05995-9"},{"key":"2026060612001057000_2026.06.01.729412v1.87","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06492-9"},{"key":"2026060612001057000_2026.06.01.729412v1.88","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq5729"},{"key":"2026060612001057000_2026.06.01.729412v1.89","doi-asserted-by":"publisher","DOI":"10.1007\/BF00414034"},{"key":"2026060612001057000_2026.06.01.729412v1.90","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.10.007"},{"issue":"1","key":"2026060612001057000_2026.06.01.729412v1.91","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0022-3565(24)39219-5","article-title":"Selectively bred lines of mice show response and drug specificity for genetic regulation of acute functional tolerance to ethanol and pentobarbital","volume":"293","year":"2000","journal-title":"J Pharmacol Exp Ther"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.01.729412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:00:26Z","timestamp":1780772426000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.01.729412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":91,"URL":"https:\/\/doi.org\/10.64898\/2026.06.01.729412","relation":{},"subject":[],"published":{"date-parts":[[2026,6,4]]},"subtype":"preprint"}}