{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:56:02Z","timestamp":1785426962924,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,3]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["U19AI181960"],"award-info":[{"award-number":["U19AI181960"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K12TR004411"],"award-info":[{"award-number":["K12TR004411"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32-GM149364"],"award-info":[{"award-number":["T32-GM149364"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32-AI08117"],"award-info":[{"award-number":["T32-AI08117"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["HT9425-24-1-0873"],"award-info":[{"award-number":["HT9425-24-1-0873"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Powassan virus (POWV) is an emerging tick-borne flavivirus that can cause severe encephalitis in humans. Currently no vaccines or therapeutics are approved to treat POWV. POWV is spread by the deer tick,\n                  <jats:italic>Ixodes scapularis<\/jats:italic>\n                  , which is ubiquitous across the Northeastern United States. To better understand POWV prevalence in high-risk populations, we examined POWV seroprevalence in Cadets at United States Military Academy (USMA) in West Point, New York. Cadets at USMA, located in a heavily wooded area, are at high risk for tick exposure during outdoor military training. 1,051 serum samples from the Cadet class of 2017 were screened for POWV seropositivity using a POWV Envelope (E) DIII ELISA. A seropositivity rate of 1.3% was determined. Several ELISA-positive samples were also able to neutralize both reporter virus particles bearing the POWV E protein and authentic POWV. This study demonstrates populations at risk for tick exposure may have significant seroprevalence of POWV.\n                <\/jats:p>","DOI":"10.64898\/2026.06.02.26354611","type":"posted-content","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:30:18Z","timestamp":1780543818000},"source":"Crossref","is-referenced-by-count":0,"title":["Powassan Virus Seroprevalence in a U.S. Servicemember Population at High Risk for Tick Exposure"],"prefix":"10.64898","author":[{"given":"Alexandra L.","family":"Tse","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoey","family":"Dipasqua","sequence":"additional","affiliation":[{"name":"United States Military Academy, Department of Life Sciences, Highland Falls, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"El 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