{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:43:54Z","timestamp":1785437034835,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,3]]},"group-title":"Neurology","reference-count":37,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"NINDS, NIH","award":["NS060722"],"award-info":[{"award-number":["NS060722"]}]},{"name":"NINDS, NIH","award":["NS082151"],"award-info":[{"award-number":["NS082151"]}]},{"name":"NINDS, NIH","award":["TR002014"],"award-info":[{"award-number":["TR002014"]}]},{"award":["18078"],"award-info":[{"award-number":["18078"]}],"id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"publisher"}]},{"name":"University of Virginia Translational Research Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>\n                  A\n                  <jats:sc>bstract<\/jats:sc>\n                <\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Higher iron occurs in the substantia nigra in Parkinson\u2019s disease (PD), but its behavior over time is poorly understood.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine if nigral iron measured by quantitative susceptibility MRI can track progression of early stages of PD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-four early-stage PD patients (disease duration &lt; 4 yrs) and 35 matched controls were recruited. Iron content in the substantia nigra and related regions was obtained using quantitative susceptibility mapping with zero-referencing at both baseline and one-year follow-up, along with clinical metrics.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of five clinic metrics and five regional iron measures, only MDS-UPDRS II (p = 0.046) and SNc iron (p = 0.004) showed significant changes for PD subjects in the one-year epoch. The changes of SNc iron also were correlated with changes of MDS-UPDRS II (p = 0.005).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Nigral iron content measured by zero-referencing is sensitive for tracking disease progression in early-stage PD.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.02.26354736","type":"posted-content","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:30:18Z","timestamp":1780543818000},"source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal changes of iron in the substantia nigra of early-stage Parkinson\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-0301","authenticated-orcid":false,"given":"Guangwei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neurology, Penn State Milton S. 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