{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:12:34Z","timestamp":1792825954285,"version":"4.5.0"},"posted":{"date-parts":[[2026,6,4]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":50,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Tommy Fuss Center for Neuropsychiatric Disease Research","award":["Next Generation Award"],"award-info":[{"award-number":["Next Generation Award"]}]},{"name":"Tommy Fuss Center for Neuropsychiatric Disease Research","award":["Research Fellowship Award"],"award-info":[{"award-number":["Research Fellowship Award"]}]},{"award":["R01MH129636"],"award-info":[{"award-number":["R01MH129636"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>Persistent, distressing psychotic-like experiences (PLEs) are associated with neurobiological alterations and increased psychosis risk. We combined individual-level neuroimaging measures with effect sizes from large neuroimaging studies to create a summary score (\u2018Psychosis Neuroscore\u2019) reflecting neuroanatomic liability for psychosis, and examined its ability to predict PLE trajectories in young adolescents.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Method.<\/jats:title>\n                  <jats:p>Using latent growth mixture models, we estimated PLE trajectories from four annual visits of the Adolescent Brain Cognitive Development Study (N=9584, ages 9-10 at baseline). Using baseline T1-weighted and diffusion-weighted imaging data, we calculated Psychosis Neuroscores, as well as Neuroscores for two psychiatric disorders with late adolescent\/adult onset (Major Depressive Disorder, Bipolar Disorder). We compared Psychosis Neuroscores to i) other psychiatric Neuroscores, ii) modifiable risk factors, and iii) established risk factors in predicting trajectory membership.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>\n                    We identified four trajectories of distressing PLEs: Persistent Elevated (N=1,968, 21%), Gradual Decreasing (N=3,424, 36%), Rapid Decreasing (N=1,593, 17%) and Low\/No Distress (N=2,599, 27%). Adolescents with Persistent Elevated PLEs had significantly higher Multimodal (combined T1 and diffusion-weighted) and T1-weighted Psychosis Neuroscores than all other trajectories (Odds Ratios [ORs] 1.27-1.34,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>FDR<\/jats:sub>\n                    &lt;.01). Bipolar Disorder Neuroscores showed a similar pattern (ORs 1.16-1.23,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>FDR<\/jats:sub>\n                    &lt;.01). Psychosis Neuroscores showed comparable associations with established risk factors in predicting trajectory membership, but smaller associations than modifiable risk factors, including screen time, physical activity, and sleep disturbances.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>Psychosis Neuroscores differentiate youth with persistent PLEs from those with decreasing, remitting or low PLEs, demonstrating their potential utility for early risk stratification. Integration with established risk factors may enhance psychosis risk prediction in youth.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.03.26354754","type":"posted-content","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:35:18Z","timestamp":1780616118000},"source":"Crossref","is-referenced-by-count":1,"title":["Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-5141","authenticated-orcid":false,"given":"Rebecca","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Boston Children\u2019s Hospital, Boston, MA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6433-0626","authenticated-orcid":false,"given":"Rashmi","family":"Sahasrabudhe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Boston Children\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4749-6977","authenticated-orcid":false,"given":"David C","family":"Glahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Boston Children\u2019s Hospital, Boston, MA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA"},{"name":"Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-9432","authenticated-orcid":false,"given":"Maria","family":"Jalbrzikowski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Boston Children\u2019s Hospital, Boston, MA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, 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