{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:08:28Z","timestamp":1785434908144,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,9]]},"group-title":"Immunology","reference-count":102,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01AI153195"],"award-info":[{"award-number":["R01AI153195"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21AI180561"],"award-info":[{"award-number":["R21AI180561"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI191470"],"award-info":[{"award-number":["R01AI191470"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["EDUC5-13636"],"award-info":[{"award-number":["EDUC5-13636"]}],"id":[{"id":"https:\/\/ror.org\/03nawhv43","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"crossref","award":["EDUC4-12752"],"award-info":[{"award-number":["EDUC4-12752"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Obesity, a rising epidemic in the United States, is causally associated with adipose tissue inflammation, therefore targeting this immune dysfunction offers promising therapeutic avenues. Chronic helminth infection can prevent obesity pathogenesis but there remain opportunities to determine the immune factors that mediate protection and whether long-term protection is associated with changes in the visceral adipose tissue. We optimized a mouse model of western diet-induced obesity and investigated if transient helminth infection was protective through the immunoregulatory protein RELM\u03b1. Wild-type (WT) or RELM\u03b1 knockout (KO) C57BL\/6J mice were fed a western diet of high glucose and high fat followed by infection with helminth\n                  <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>\n                  , which infects the lung and small intestine but is cleared within two weeks. Infection attenuated weight gain and improved glucose tolerance even after the parasite was expelled in WT but not RELM\u03b1 deficient mice. This protection was associated with reduced adipocyte hypertrophy in WT mice. Adipose tissue bulk RNA sequencing and digital cell quantification indicated that RELM\u03b1 promoted enrichment of eosinophils and M2 macrophages and upregulated pathways associated with fatty acid oxidation, mitochondrial function, and thermogenesis, whereas RELM\u03b1 deficiency led to pro-inflammatory, fibrotic, and lipid accumulation transcriptional profiles. Specific genes that were changed with infection and RELM\u03b1 deficiency included collagen and serpin genes associated with tissue remodeling and fibrosis, and changes within the adipose tissue was confirmed by immunofluorescent staining. Together, these findings establish that helminth-induced RELM\u03b1 critically protects against western diet\u2013driven obesity and associated adipose transcriptional reprogramming and tissue remodeling.\n                <\/jats:p>","DOI":"10.64898\/2026.06.04.730169","type":"posted-content","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:35:12Z","timestamp":1781022912000},"source":"Crossref","is-referenced-by-count":0,"title":["Helminth infection induces RELM\u03b1-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesity"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1638-275X","authenticated-orcid":false,"given":"Jennell","family":"Jennett","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-0233","authenticated-orcid":false,"given":"Rebecca E.","family":"Ruggiero-Ruff","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Man","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-6022","authenticated-orcid":false,"given":"Kyle","family":"Anesko","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Midou","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-6850","authenticated-orcid":false,"given":"Shaokui","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-5161","authenticated-orcid":false,"given":"Meera G.","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California, Riverside; Riverside, CA 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061113350621000_2026.06.04.730169v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz273"},{"key":"2026061113350621000_2026.06.04.730169v1.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1909301"},{"key":"2026061113350621000_2026.06.04.730169v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.005"},{"key":"2026061113350621000_2026.06.04.730169v1.4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314982"},{"key":"2026061113350621000_2026.06.04.730169v1.5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00329.2010"},{"key":"2026061113350621000_2026.06.04.730169v1.6","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/load021"},{"key":"2026061113350621000_2026.06.04.730169v1.7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100263"},{"key":"2026061113350621000_2026.06.04.730169v1.8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0692"},{"key":"2026061113350621000_2026.06.04.730169v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109159"},{"key":"2026061113350621000_2026.06.04.730169v1.10","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0180"},{"key":"2026061113350621000_2026.06.04.730169v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.066"},{"key":"2026061113350621000_2026.06.04.730169v1.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0947"},{"key":"2026061113350621000_2026.06.04.730169v1.13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2026.1721206"},{"key":"2026061113350621000_2026.06.04.730169v1.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020081"},{"key":"2026061113350621000_2026.06.04.730169v1.15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.827486"},{"key":"2026061113350621000_2026.06.04.730169v1.16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-266239"},{"key":"2026061113350621000_2026.06.04.730169v1.17","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1229"},{"key":"2026061113350621000_2026.06.04.730169v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22920-7"},{"key":"2026061113350621000_2026.06.04.730169v1.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010105"},{"key":"2026061113350621000_2026.06.04.730169v1.20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02195"},{"key":"2026061113350621000_2026.06.04.730169v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.002"},{"key":"2026061113350621000_2026.06.04.730169v1.22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86001"},{"key":"2026061113350621000_2026.06.04.730169v1.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000393"},{"key":"2026061113350621000_2026.06.04.730169v1.24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011658"},{"key":"2026061113350621000_2026.06.04.730169v1.25","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau3814"},{"key":"2026061113350621000_2026.06.04.730169v1.26","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12236"},{"key":"2026061113350621000_2026.06.04.730169v1.27","doi-asserted-by":"publisher","DOI":"10.3389\/fpara.2023.1242866"},{"key":"2026061113350621000_2026.06.04.730169v1.28","doi-asserted-by":"publisher","DOI":"10.1002\/msb.134947"},{"key":"2026061113350621000_2026.06.04.730169v1.29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw535"},{"key":"2026061113350621000_2026.06.04.730169v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4485"},{"key":"2026061113350621000_2026.06.04.730169v1.31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.716801"},{"key":"2026061113350621000_2026.06.04.730169v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.03.001"},{"key":"2026061113350621000_2026.06.04.730169v1.33","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R052902"},{"key":"2026061113350621000_2026.06.04.730169v1.34","doi-asserted-by":"publisher","DOI":"10.3181\/0710-MR-287"},{"key":"2026061113350621000_2026.06.04.730169v1.35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184120"},{"key":"2026061113350621000_2026.06.04.730169v1.36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.491324"},{"key":"2026061113350621000_2026.06.04.730169v1.37","unstructured":"Fibulin-7 in progenitor cells promotes adipose tissue fibrosis and disrupts metabolic homeostasis in obesity | Protein & Cell | Oxford Academic. Accessed April 28, 2026. https:\/\/academic.oup.com\/proteincell\/article\/17\/3\/212\/8300200?__cf_chl_tk=U_quXII.bVFHG1OVEGcBST4FaDagrJe8X1Elp6bAUSE-1777434521-1.0.1.1-TgZ_QXOQGqQN1SClrxNkbUQTwn2BL.XK9H6Jc.Z4xzU"},{"key":"2026061113350621000_2026.06.04.730169v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119648"},{"key":"2026061113350621000_2026.06.04.730169v1.39","unstructured":"Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology | Physiological Genomics | American Physiological Society. P hysiological Genomics. Accessed March 4, 2026. https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00092.2004"},{"key":"2026061113350621000_2026.06.04.730169v1.40","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaf096"},{"key":"2026061113350621000_2026.06.04.730169v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.83"},{"key":"2026061113350621000_2026.06.04.730169v1.42","unstructured":"Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution: The American Journal of Human Genetics. Accessed April 28, 2026. https:\/\/www.cell.com\/ajhg\/fulltext\/S0002-9297(25)00323-4"},{"key":"2026061113350621000_2026.06.04.730169v1.43","unstructured":"Myllyharju J , Kivirikko KI . Collagens, modifying enzymes and their mutations in humans, flies and worms. Accessed March 5, 2026. https:\/\/www.cell.com\/trends\/genetics\/abstract\/S0168-9525(03)00319-6"},{"key":"2026061113350621000_2026.06.04.730169v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152124"},{"key":"2026061113350621000_2026.06.04.730169v1.45","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-018-0166-8"},{"key":"2026061113350621000_2026.06.04.730169v1.46","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1790-4"},{"key":"2026061113350621000_2026.06.04.730169v1.47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002375"},{"key":"2026061113350621000_2026.06.04.730169v1.48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008101"},{"key":"2026061113350621000_2026.06.04.730169v1.49","unstructured":"R L, S H, A M, et al. Role of FKBP5 in adipose tissue function: Implications for obesity and insulin sensitivity. PubMed. Accessed April 28, 2026. https:\/\/pubmed.ncbi.nlm.nih.gov\/41397645\/"},{"key":"2026061113350621000_2026.06.04.730169v1.50","unstructured":"Ad S, H S, R O, Rj S, O R. The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents. PubMed. Accessed April 28, 2026. https:\/\/pubmed.ncbi.nlm.nih.gov\/17567964\/"},{"key":"2026061113350621000_2026.06.04.730169v1.51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218244"},{"key":"2026061113350621000_2026.06.04.730169v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0610-4"},{"key":"2026061113350621000_2026.06.04.730169v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108810"},{"key":"2026061113350621000_2026.06.04.730169v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(01)00017-0"},{"key":"2026061113350621000_2026.06.04.730169v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.005"},{"key":"2026061113350621000_2026.06.04.730169v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108810"},{"key":"2026061113350621000_2026.06.04.730169v1.57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003126"},{"key":"2026061113350621000_2026.06.04.730169v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-024-00039-w"},{"key":"2026061113350621000_2026.06.04.730169v1.59","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.947492"},{"key":"2026061113350621000_2026.06.04.730169v1.60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.303255"},{"key":"2026061113350621000_2026.06.04.730169v1.61","unstructured":"Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society. American Journal of Physiology-Endocrinology and Metabolism. Accessed March 5, 2026. https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00526.2002"},{"key":"2026061113350621000_2026.06.04.730169v1.62","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/456347"},{"key":"2026061113350621000_2026.06.04.730169v1.63","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13080271"},{"key":"2026061113350621000_2026.06.04.730169v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00902-6"},{"key":"2026061113350621000_2026.06.04.730169v1.65","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M041392"},{"key":"2026061113350621000_2026.06.04.730169v1.66","doi-asserted-by":"publisher","DOI":"10.1530\/EC-14-0107"},{"key":"2026061113350621000_2026.06.04.730169v1.67","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040940"},{"key":"2026061113350621000_2026.06.04.730169v1.68","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26206"},{"key":"2026061113350621000_2026.06.04.730169v1.69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00605.2004"},{"key":"2026061113350621000_2026.06.04.730169v1.70","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000242905.41404.68"},{"key":"2026061113350621000_2026.06.04.730169v1.71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00549.2013"},{"key":"2026061113350621000_2026.06.04.730169v1.72","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0801-2"},{"key":"2026061113350621000_2026.06.04.730169v1.73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.002812"},{"key":"2026061113350621000_2026.06.04.730169v1.74","unstructured":"Y J, M A, H A, et al. The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study. PubMed. Accessed April 28, 2026. https:\/\/pubmed.ncbi.nlm.nih.gov\/36758722\/"},{"key":"2026061113350621000_2026.06.04.730169v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108398"},{"key":"2026061113350621000_2026.06.04.730169v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.208"},{"key":"2026061113350621000_2026.06.04.730169v1.77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504703102"},{"key":"2026061113350621000_2026.06.04.730169v1.78","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2026.1721206"},{"key":"2026061113350621000_2026.06.04.730169v1.79","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-025-00972-7"},{"key":"2026061113350621000_2026.06.04.730169v1.80","doi-asserted-by":"publisher","DOI":"10.3390\/nu14112229"},{"key":"2026061113350621000_2026.06.04.730169v1.81","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2023.1193480"},{"key":"2026061113350621000_2026.06.04.730169v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2022.107012"},{"key":"2026061113350621000_2026.06.04.730169v1.83","doi-asserted-by":"publisher","DOI":"10.1111\/all.12031"},{"key":"2026061113350621000_2026.06.04.730169v1.84","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12958"},{"key":"2026061113350621000_2026.06.04.730169v1.85","unstructured":"Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma - Journal of Allergy and Clinical Immunology. Accessed April 28, 2026. https:\/\/www.jacionline.org\/article\/S0091-6749(21)01525-6\/fulltext"},{"key":"2026061113350621000_2026.06.04.730169v1.86","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093173"},{"key":"2026061113350621000_2026.06.04.730169v1.87","unstructured":"Taguchi T , Razzaque MS. The collagen-specific molecular chaperone HSP47: is there a role in fibrosis? Accessed March 5, 2026. https:\/\/www.cell.com\/trends\/molecular-medicine\/abstract\/S1471-4914(06)00266-8"},{"key":"2026061113350621000_2026.06.04.730169v1.88","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209196200"},{"key":"2026061113350621000_2026.06.04.730169v1.89","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01087"},{"key":"2026061113350621000_2026.06.04.730169v1.90","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0312-6"},{"key":"2026061113350621000_2026.06.04.730169v1.91","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800018-JLR200"},{"key":"2026061113350621000_2026.06.04.730169v1.92","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-020-00566-3"},{"key":"2026061113350621000_2026.06.04.730169v1.93","doi-asserted-by":"publisher","DOI":"10.1002\/imo2.59"},{"key":"2026061113350621000_2026.06.04.730169v1.94","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0012"},{"key":"2026061113350621000_2026.06.04.730169v1.95","unstructured":"Babraham Bioinformatics - FastQC A Quality Control tool for High Throughput Sequence Data. Accessed April 28, 2026. https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/?utm_source=chatgpt.com"},{"key":"2026061113350621000_2026.06.04.730169v1.96","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"2026061113350621000_2026.06.04.730169v1.97","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"2026061113350621000_2026.06.04.730169v1.98","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026061113350621000_2026.06.04.730169v1.99","doi-asserted-by":"crossref","unstructured":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features | Bioinformatics | Oxford Academic. Accessed April 28, 2026. https:\/\/academic.oup.com\/bioinformatics\/article\/30\/7\/923\/232889?login=false","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"2026061113350621000_2026.06.04.730169v1.100","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026061113350621000_2026.06.04.730169v1.101","unstructured":"G Y, Lg W , Y H, Qy H . clusterProfiler: an R package for comparing biological themes among gene clusters. PubMed. Accessed April 28, 2026. https:\/\/pubmed.ncbi.nlm.nih.gov\/22455463\/?utm_source=chatgpt.com"},{"key":"2026061113350621000_2026.06.04.730169v1.102","unstructured":"Bioconductor - org.Mm.eg.db. Accessed April 28, 2026. https:\/\/www.bioconductor.org\/packages\/\/2.7\/data\/annotation\/html\/org.Mm.eg.db.html?utm_source=chatgpt.com\/"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.04.730169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:35:15Z","timestamp":1781210115000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.04.730169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":102,"URL":"https:\/\/doi.org\/10.64898\/2026.06.04.730169","relation":{},"subject":[],"published":{"date-parts":[[2026,6,9]]},"subtype":"preprint"}}