{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:55:46Z","timestamp":1781340946020,"version":"3.54.1"},"posted":{"date-parts":[[2026,6,10]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":24,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Low-level systemic inflammation has been associated with late-life depressive symptoms. Whether individuals with higher inflammation derive preventive benefit from low-dose aspirin therapy is unknown.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a post-hoc analysis of the ASPiring in Reducing Events in the Elderly (ASPREE) randomised, double-blind, placebo-controlled trial. Baseline C-reactive protein (hsCRP) was measured in plasma and depressive symptoms were assessed annually using the Center for Epidemiologic Studies Depression 10 Scale (CES-D-10) with elevated symptoms defined as CES-D-10 \u2265 8. Participants with elevated depressive symptoms at baseline were excluded. We fitted population-averaged logistic generalised estimating equation models adjusted for baseline sociodemographic and lifestyle covariates, including an hsCRP \u00d7 treatment interaction to test effect modification by aspirin.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher baseline hsCRP was associated with increased odds of elevated depressive symptoms during follow-up (OR 1.07 per SD increase in hsCRP, 95% CI 1.03\u20131.11). Low-dose aspirin allocation did not modify the hsCRP-depressive symptoms association (interaction OR 1.02, 95% CI 0.94\u20131.10).<\/jats:p>\n                  <jats:p>Findings were similar after additional adjustment for comorbidity and other covariates.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In community-dwelling older adults during the ASPREE randomised trial period, higher baseline hsCRP was modestly associated with elevated depressive symptoms. There was no evidence that low-dose aspirin was associated with reduced risk of depressive symptoms among participants with higher baseline inflammation.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.05.26354416","type":"posted-content","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:45:15Z","timestamp":1781109915000},"source":"Crossref","is-referenced-by-count":0,"title":["Inflammation and late-life depressive symptoms"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-6471","authenticated-orcid":false,"given":"M.","family":"Forbes","sequence":"first","affiliation":[{"name":"Mental Health, Drugs and Alcohol Service, Barwon Health, Geelong, Victoria, Australia"},{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lotfaliany","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mengist","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-M.","family":"Isvoranu","sequence":"additional","affiliation":[{"name":"Department of Psychology, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-6798","authenticated-orcid":false,"given":"P.","family":"Lacaze","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Neuropsychiatry Centre, The Royal Melbourne Hospital, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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