{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T16:51:46Z","timestamp":1781974306562,"version":"3.54.5"},"posted":{"date-parts":[[2026,6,18]]},"group-title":"Genetic and Genomic Medicine","reference-count":60,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["R01-HG009922"],"award-info":[{"award-number":["R01-HG009922"]}]},{"name":"NIH","award":["R03-HG008809"],"award-info":[{"award-number":["R03-HG008809"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Elective genomic sequencing (EGS) returns monogenic disease findings in multiple genes, including potentially novel variants, and may also provide participants with carrier status, pharmacogenomic and other health-related information. The PeopleSeq Study assessed participants\u2019 motivations for and concerns about EGS and the associated clinical and psychosocial outcomes across diverse EGS providers.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We administered a shared questionnaire to participants who chose to undergo EGS via 18 academic, clinical, or commercial EGS platforms.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    We enrolled 1575 participants, of whom 1147 (72.8%) completed a questionnaire after receiving their EGS results. A majority (60.3%) of the participants who completed a post-result questionnaire self-reported receiving results they assessed as important, including negative findings, and 75.9% reported a form of health-related utility. Among a subset (19.4%) who shared their EGS reports, 16.6% (37 of\n                    <jats:italic>n<\/jats:italic>\n                    =223) received a monogenic finding and self-reported results deemed \u201cimportant\u201d were consistent with EGS reports. Most participants (74.1%) discussed their results with their family, but fewer discussed their results with a healthcare provider other than the site team (41.7%) or had one or more medical visits as a direct result of their EGS testing (23.1%). Participants expressed diverse motivations for EGS, with 91.4% expressing interest in their personal disease risk and 54% who expressed quasi-indication-based motivations related to family medical history. Individuals motivated by family history reported important results at a significantly higher rate.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early adopters of EGS are motivated by general interest in their health as well as quasi-indication-based considerations such as family history. A majority of participants learned results they considered medically important, but a much smaller segment engaged healthcare providers with their results.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.09.26355296","type":"posted-content","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:15:13Z","timestamp":1781838913000},"source":"Crossref","is-referenced-by-count":0,"title":["Elective genomic sequencing for adults in research, clinical and commercial contexts"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-7148","authenticated-orcid":false,"given":"Michael D.","family":"Linderman","sequence":"first","affiliation":[{"name":"Department of Computer Science, Middlebury College, Middlebury, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6236-6812","authenticated-orcid":false,"given":"Sophia M.","family":"Adelson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mass General Brigham, Boston, MA, USA"},{"name":"Stanford School of Medicine, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-6336","authenticated-orcid":false,"given":"Tala M.","family":"Berro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mass General Brigham, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Individualized Medicine, Mayo Clinic. 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