{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:32:14Z","timestamp":1791775934749,"version":"4.3.4"},"posted":{"date-parts":[[2026,6,12]]},"group-title":"Pediatrics","reference-count":66,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Department of Defense Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["GRANT13451092"],"award-info":[{"award-number":["GRANT13451092"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000090","name":"Department of Defense Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["GRANT13450969"],"award-info":[{"award-number":["GRANT13450969"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000090","name":"Department of Defense Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["GRANT13450947"],"award-info":[{"award-number":["GRANT13450947"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCTN Operations Center","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}]},{"name":"NCTN Statistics & Data Center","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}]},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"crossref","award":["U54 CA274516"],"award-info":[{"award-number":["U54 CA274516"]}],"id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["FBD# 199461"],"award-info":[{"award-number":["FBD# 199461"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  High-risk neuroblastoma (HRNB) is a leading cause of pediatric cancer death. Current therapies center on intensive multimodal treatment including anti-GD2 therapy, with growing interest in harnessing T cell-mediated immunity. How T cells and their receptors (T-cell receptors, TCRs) are spatially organized and function within tumors remains poorly defined. To assess whether intratumoral location influences clonotype-specific T cell states, we profiled TCR repertoires across blood and tumor samples from 37 patients with HRNB using longitudinal bulk TCR sequencing. In a nested subset of 5 patients with paired pre- and post-therapy tumors, we integrated spatial transcriptomics with\n                  <jats:italic>in situ<\/jats:italic>\n                  TCR profiling. Across all tumors, T and B cells preferentially co-localized in immune-rich regions and showed reduced proximity to neuroblast cells. Despite this compartmentalized architecture, \u03b3\u03b4T cells were more evenly distributed across tumor sections and showed greater proximity to neuroblast-rich regions than other T cell subsets. Within TCR clonotypes, spatial location was associated with distinct transcriptional states, with immune-rich regions supporting more progenitor-like programs. These findings identify spatial context as a key determinant of phenotype clonotype-specific T cell phenotype and highlight \u03b3\u03b4T cells cells as a spatially distinct population with potential roles in neuroblastoma tumor-immune interactions.\n                <\/jats:p>","DOI":"10.64898\/2026.06.10.26354144","type":"posted-content","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:15:22Z","timestamp":1781313322000},"source":"Crossref","is-referenced-by-count":1,"title":["Spatially resolved T cell receptor tracking reveals \u03b3\u03b4T cell localization to tumor-rich regions in high-risk neuroblastoma: A Report from the Children\u2019s Oncology Group"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-9763","authenticated-orcid":false,"given":"Yiyue","family":"Jiang","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto ON, Canada"},{"name":"Medical Biophysics, University of 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