{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:51:21Z","timestamp":1785433881700,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,12]]},"group-title":"Microbiology","reference-count":82,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["1R03AI176262-01"],"award-info":[{"award-number":["1R03AI176262-01"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                  is a thermotolerant saprobe found in soils and plant debris worldwide and an important pathogen of humans causing two million deaths annually.\n                  <jats:italic>A. fumigatus<\/jats:italic>\n                  makes abundant asexual spores (conidia) which are widely distributed by wind and can be inhaled from the environment. In susceptible individuals inhaled conidia break dormancy, germinate and grow in the lung leading to serious disease. Recent work has shown that conidia made at 37\u00b0C and 50\u00b0C have different morphologies and germination kinetics. While the asexual cycle is well-characterized at 37\u00b0C, much less is known about the asexual cycle at 50\u00b0C.\n                <\/jats:p>\n                <jats:p>\n                  Here, we combine flow cytometry and transcriptomics to track morphology and gene expression in the hyphae, conidiophores and conidia of\n                  <jats:italic>A. fumigatus<\/jats:italic>\n                  during asexual development at 37\u00b0C or 50\u00b0C. We show that the temperature during a narrow time window in late-stage conidiophore development dictates resulting conidial morphology, transcriptional program, and germination kinetics. As expected, conidiation at 37\u00b0C resulted in upregulation of\n                  <jats:italic>brlA,<\/jats:italic>\n                  the master regulator of asexual development, and its downstream targets in conidiophores and conidia. Surprisingly, conidiation at 50\u00b0C resulted in upregulation of\n                  <jats:italic>MAT1-1<\/jats:italic>\n                  , the master regulator of sexual development and its downstream targets in conidiophores and conidia. Our findings suggest that temperature during late conidiophore development transcriptionally primes conidia for asexual, parasexual or sexual development enhancing chances of survival for progeny. Our findings are especially relevant for agricultural compost where a wide gradient of temperatures exists, abundant\n                  <jats:italic>A. fumigatus<\/jats:italic>\n                  has been isolated, and resistance to antifungals is thought to evolve.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>IMPORTANCE<\/jats:title>\n                  <jats:p>\n                    The human pathogen\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    has been found in natural and agricultural environments around the world. Disease is acquired when susceptible individuals inhale airborne asexual spores from the environment, which in agriculture generally includes proximity to compost and plant debris piles. This work shows that the environmental temperature when\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    spores are made determines the transcriptomes of those spores, priming them for future asexual or sexual development. The survival of asexual and sexual spores is very different at different temperatures, so these results are important for understanding how this pathogen survives in varied hostile environments. In addition, there are very few antifungal drugs with which to treat\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    infections, and resistance is increasing driven in part by agricultural use of fungicides. These results suggest that higher temperatures during asexual spore formation can lead to increased sexual reproduction and greater chances to evolve antifungal resistance.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.11.730956","type":"posted-content","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:20:19Z","timestamp":1781324419000},"source":"Crossref","is-referenced-by-count":0,"title":["Temperature during\n                  <i>Aspergillus fumigatus<\/i>\n                  conidiophore development primes spore transcriptome for asexual, parasexual or sexual development"],"prefix":"10.64898","author":[{"given":"Justina M.","family":"Stanislaw","sequence":"first","affiliation":[{"name":"Fungal Biology Group and Plant Biology Department, The University of Georgia, 2502 Plant Sciences, Athens, Georgia USA 30602-7271"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-063X","authenticated-orcid":false,"given":"Michelle","family":"Momany","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Biology Department, The University of Georgia, 2502 Plant Sciences, Athens, Georgia USA 30602-7271"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061519300888000_2026.06.11.730956v1.1","doi-asserted-by":"crossref","unstructured":"Parums DV. 2022. 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