{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:02:00Z","timestamp":1785420120434,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,12]]},"group-title":"Immunology","reference-count":140,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["Koch Institute Support (core) Grant (P30-CA14051)"],"award-info":[{"award-number":["Koch Institute Support (core) Grant (P30-CA14051)"]}]},{"name":"National Science Foundation","award":["Graduate Research Fellowship Program (2141064)"],"award-info":[{"award-number":["Graduate Research Fellowship Program (2141064)"]}]},{"id":[{"id":"https:\/\/ror.org\/02f3xk561","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["Stable Isotope and Metabolomics Core Facility of the Diabetes Research and Training Center (P60DK020541)"],"award-info":[{"award-number":["Stable Isotope and Metabolomics Core Facility of the Diabetes Research and Training Center (P60DK020541)"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Cytokine production is a core function of effector T cells, yet the mechanisms that regulate cytokine output during an immune response remain incompletely understood. Here, we identify citrate compartmentalization as a cellular mechanism by which CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells couple cytokine production to glucose availability. Under glucose-replete conditions, citrate transport from the mitochondria to the cytosol by the citrate carrier SLC25A1 suppresses calcium-dependent transcription factor activity in effector T cells. Either reducing glucose availability or blocking the exchange of citrate across the mitochondrial membrane raises free cytosolic calcium, thereby driving nuclear localization of Nuclear Factor of Activated T cells (NFAT)-family transcription factors and sustaining cytokine production. As a calcium-chelating metabolite, we show that citrate buffers free cytosolic calcium, thereby linking calcium-dependent signaling to mitochondrial fuel oxidation. We also identify signatures of this regulatory mechanism across hundreds of human cancer cell lines, where there are negative associations between citrate-derived metabolites and calcium-dependent transcriptional programs, and within the spatial organization of human tumors. These findings identify cytosolic citrate as a broadly conserved metabolic rheostat coupling glucose availability to calcium signaling. By adding calcium signaling to the known functions regulated by SLC25A1, our work reveals a mechanism by which mitochondria adaptively tune cytokine expression and other calcium-dependent programs in response to local metabolic conditions, such as nutrients that are available within a tissue or tumor.\n                <\/jats:p>","DOI":"10.64898\/2026.06.11.731694","type":"posted-content","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:30:31Z","timestamp":1781310631000},"source":"Crossref","is-referenced-by-count":0,"title":["Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-3744","authenticated-orcid":false,"given":"Andrea L.","family":"Cote","sequence":"first","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA"},{"name":"MIT Biology Department, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-7724","authenticated-orcid":false,"given":"Claire L.","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA"},{"name":"MIT Biology Department, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-2428","authenticated-orcid":false,"given":"Joshua A.","family":"Acklin","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA"},{"name":"MIT Biology Department, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0486-3415","authenticated-orcid":false,"given":"Lillian R.","family":"Delacruz","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA"},{"name":"MIT Biology Department, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-5264","authenticated-orcid":false,"given":"Yunping","family":"Qiu","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Division of Endocrinology, Bronx, NY USA 10461"},{"name":"Stable Isotope and Metabolomics Core Facility, New York Regional Diabetes Research Center at the Albert Einstein College of Medicine, Bronx, NY, USA 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-1917","authenticated-orcid":false,"given":"Irwin J.","family":"Kurland","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Division of Endocrinology, Bronx, NY USA 10461"},{"name":"Stable Isotope and Metabolomics Core Facility, New York Regional Diabetes Research Center at the Albert Einstein College of Medicine, Bronx, NY, USA 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-9376","authenticated-orcid":false,"given":"Alison E.","family":"Ringel","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA"},{"name":"MIT Biology Department, Cambridge, MA 02139, USA"},{"name":"Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061519550638000_2026.06.11.731694v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IMMUNI.2011.09.021"},{"key":"2026061519550638000_2026.06.11.731694v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00323-0"},{"key":"2026061519550638000_2026.06.11.731694v1.3","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.180.7.4476"},{"key":"2026061519550638000_2026.06.11.731694v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.008"},{"key":"2026061519550638000_2026.06.11.731694v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/J.MITO.2007.08.001"},{"key":"2026061519550638000_2026.06.11.731694v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.007"},{"key":"2026061519550638000_2026.06.11.731694v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/nri1710"},{"key":"2026061519550638000_2026.06.11.731694v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/J.IT.2012.01.010"},{"key":"2026061519550638000_2026.06.11.731694v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"2026061519550638000_2026.06.11.731694v1.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"2026061519550638000_2026.06.11.731694v1.11","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20221839"},{"key":"2026061519550638000_2026.06.11.731694v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(70)90182-0"},{"key":"2026061519550638000_2026.06.11.731694v1.13","doi-asserted-by":"publisher","DOI":"10.1042\/BJ1100373"},{"key":"2026061519550638000_2026.06.11.731694v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(76)90005-2"},{"key":"2026061519550638000_2026.06.11.731694v1.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1963.tb05446.x"},{"key":"2026061519550638000_2026.06.11.731694v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2018.01.040"},{"key":"2026061519550638000_2026.06.11.731694v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01148-8"},{"key":"2026061519550638000_2026.06.11.731694v1.18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003613"},{"key":"2026061519550638000_2026.06.11.731694v1.19","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20110278"},{"key":"2026061519550638000_2026.06.11.731694v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/J.IMMUNI.2021.04.008"},{"key":"2026061519550638000_2026.06.11.731694v1.21","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2683"},{"key":"2026061519550638000_2026.06.11.731694v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.012"},{"key":"2026061519550638000_2026.06.11.731694v1.23","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac8155"},{"key":"2026061519550638000_2026.06.11.731694v1.24","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838289"},{"key":"2026061519550638000_2026.06.11.731694v1.25","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.174.8.4670"},{"key":"2026061519550638000_2026.06.11.731694v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2013.05.016"},{"key":"2026061519550638000_2026.06.11.731694v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/J.IMMUNI.2012.10.020"},{"key":"2026061519550638000_2026.06.11.731694v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.030"},{"key":"2026061519550638000_2026.06.11.731694v1.29","doi-asserted-by":"crossref","unstructured":"Jacobs, S.R. , Herman, C.E. , Maciver, N.J. , Wofford, J.A. , Wieman, H.L. , Hammen, J.J. , and Rathmell, J.C. (2008). Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways 1.","DOI":"10.4049\/jimmunol.180.7.4476"},{"key":"2026061519550638000_2026.06.11.731694v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.016"},{"key":"2026061519550638000_2026.06.11.731694v1.31","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2024.12.007"},{"key":"2026061519550638000_2026.06.11.731694v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/S41591-019-0404-8"},{"key":"2026061519550638000_2026.06.11.731694v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31720-4"},{"key":"2026061519550638000_2026.06.11.731694v1.34","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.AEC4368\/SUPPL_FILE\/SCIADV.AEC4368_SM.PDF"},{"key":"2026061519550638000_2026.06.11.731694v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00913-9"},{"key":"2026061519550638000_2026.06.11.731694v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90204-2"},{"key":"2026061519550638000_2026.06.11.731694v1.37","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400325"},{"key":"2026061519550638000_2026.06.11.731694v1.38","doi-asserted-by":"publisher","DOI":"10.2337\/dc26-S002"},{"key":"2026061519550638000_2026.06.11.731694v1.39","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00351.2002"},{"key":"2026061519550638000_2026.06.11.731694v1.40","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPL.1999.87.4.1483"},{"key":"2026061519550638000_2026.06.11.731694v1.41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118043"},{"key":"2026061519550638000_2026.06.11.731694v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/J.COPBIO.2023.102970"},{"key":"2026061519550638000_2026.06.11.731694v1.43","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"2026061519550638000_2026.06.11.731694v1.44","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425485"},{"key":"2026061519550638000_2026.06.11.731694v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4"},{"key":"2026061519550638000_2026.06.11.731694v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56863-0"},{"key":"2026061519550638000_2026.06.11.731694v1.47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1101"},{"key":"2026061519550638000_2026.06.11.731694v1.48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8852-8_15"},{"key":"2026061519550638000_2026.06.11.731694v1.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003428107"},{"key":"2026061519550638000_2026.06.11.731694v1.50","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20231820\/276919"},{"key":"2026061519550638000_2026.06.11.731694v1.51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164097"},{"key":"2026061519550638000_2026.06.11.731694v1.52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204681200"},{"key":"2026061519550638000_2026.06.11.731694v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04475-w"},{"key":"2026061519550638000_2026.06.11.731694v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2026.01.028"},{"key":"2026061519550638000_2026.06.11.731694v1.55","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0031008"},{"key":"2026061519550638000_2026.06.11.731694v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)91503-X"},{"key":"2026061519550638000_2026.06.11.731694v1.57","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(83)81023-0"},{"key":"2026061519550638000_2026.06.11.731694v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(89)80068-4"},{"key":"2026061519550638000_2026.06.11.731694v1.59","doi-asserted-by":"publisher","DOI":"10.1126\/SCIIMMUNOL.ABL6322"},{"key":"2026061519550638000_2026.06.11.731694v1.60","doi-asserted-by":"publisher","DOI":"10.1042\/BJ2990001"},{"key":"2026061519550638000_2026.06.11.731694v1.61","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.85.2.228"},{"key":"2026061519550638000_2026.06.11.731694v1.62","doi-asserted-by":"publisher","DOI":"10.1038\/361315a0"},{"key":"2026061519550638000_2026.06.11.731694v1.63","doi-asserted-by":"publisher","DOI":"10.1093\/BIOADV\/VBAC016"},{"key":"2026061519550638000_2026.06.11.731694v1.64","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.3260404"},{"key":"2026061519550638000_2026.06.11.731694v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/32100"},{"key":"2026061519550638000_2026.06.11.731694v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00053-8"},{"key":"2026061519550638000_2026.06.11.731694v1.67","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf244"},{"key":"2026061519550638000_2026.06.11.731694v1.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009219107"},{"key":"2026061519550638000_2026.06.11.731694v1.69","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-14"},{"key":"2026061519550638000_2026.06.11.731694v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2026.01.028"},{"key":"2026061519550638000_2026.06.11.731694v1.71","doi-asserted-by":"publisher","DOI":"10.1038\/nature11003"},{"key":"2026061519550638000_2026.06.11.731694v1.72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32529"},{"key":"2026061519550638000_2026.06.11.731694v1.73","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.10.3436-3444.2001"},{"key":"2026061519550638000_2026.06.11.731694v1.74","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.2.149"},{"key":"2026061519550638000_2026.06.11.731694v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.144"},{"key":"2026061519550638000_2026.06.11.731694v1.76","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69735-2"},{"key":"2026061519550638000_2026.06.11.731694v1.77","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0491-6"},{"key":"2026061519550638000_2026.06.11.731694v1.78","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04411-2"},{"key":"2026061519550638000_2026.06.11.731694v1.79","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"2026061519550638000_2026.06.11.731694v1.80","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"2026061519550638000_2026.06.11.731694v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(68)90363-7"},{"key":"2026061519550638000_2026.06.11.731694v1.82","first-page":"32P","article-title":"Increased uptake of calcium by human lymphocytes treated with phytohaemagglutinin","volume":"206","year":"1970","journal-title":"J. Physiol"},{"key":"2026061519550638000_2026.06.11.731694v1.83","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0110-7"},{"key":"2026061519550638000_2026.06.11.731694v1.84","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830201016"},{"key":"2026061519550638000_2026.06.11.731694v1.85","doi-asserted-by":"publisher","DOI":"10.1038\/86318"},{"key":"2026061519550638000_2026.06.11.731694v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/nri1632"},{"key":"2026061519550638000_2026.06.11.731694v1.87","doi-asserted-by":"publisher","DOI":"10.1038\/nri3233"},{"key":"2026061519550638000_2026.06.11.731694v1.88","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV.IMMUNOL.021908.132550"},{"key":"2026061519550638000_2026.06.11.731694v1.89","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.51"},{"key":"2026061519550638000_2026.06.11.731694v1.90","doi-asserted-by":"publisher","DOI":"10.1016\/J.PLABM.2021.E00213"},{"key":"2026061519550638000_2026.06.11.731694v1.91","doi-asserted-by":"publisher","DOI":"10.24966\/he-9640\/100005"},{"key":"2026061519550638000_2026.06.11.731694v1.92","doi-asserted-by":"publisher","DOI":"10.1042\/BJ0351011"},{"key":"2026061519550638000_2026.06.11.731694v1.93","doi-asserted-by":"publisher","DOI":"10.1152\/AJPLEGACY.1959.197.2.502"},{"key":"2026061519550638000_2026.06.11.731694v1.94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2010.01511.x"},{"key":"2026061519550638000_2026.06.11.731694v1.95","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553702"},{"key":"2026061519550638000_2026.06.11.731694v1.96","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(60)90131-1"},{"key":"2026061519550638000_2026.06.11.731694v1.97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009219107"},{"key":"2026061519550638000_2026.06.11.731694v1.98","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.1983.244.3.F223"},{"key":"2026061519550638000_2026.06.11.731694v1.99","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)32009-0"},{"key":"2026061519550638000_2026.06.11.731694v1.100","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990180104"},{"key":"2026061519550638000_2026.06.11.731694v1.101","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.054"},{"key":"2026061519550638000_2026.06.11.731694v1.102","doi-asserted-by":"publisher","DOI":"10.1159\/000099343"},{"key":"2026061519550638000_2026.06.11.731694v1.103","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1300-3"},{"key":"2026061519550638000_2026.06.11.731694v1.104","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.147.3659.727.B"},{"key":"2026061519550638000_2026.06.11.731694v1.105","doi-asserted-by":"publisher","DOI":"10.1016\/S1874-6047(08)60097-9"},{"key":"2026061519550638000_2026.06.11.731694v1.106","doi-asserted-by":"publisher","DOI":"10.1042\/BJ0540078"},{"key":"2026061519550638000_2026.06.11.731694v1.107","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.28875"},{"key":"2026061519550638000_2026.06.11.731694v1.108","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(99)00225-1"},{"key":"2026061519550638000_2026.06.11.731694v1.109","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.2212178119\/-\/DCSUPPLEMENTAL"},{"key":"2026061519550638000_2026.06.11.731694v1.110","doi-asserted-by":"publisher","DOI":"10.2174\/1876525401406010001"},{"key":"2026061519550638000_2026.06.11.731694v1.111","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(03)00249-6"},{"key":"2026061519550638000_2026.06.11.731694v1.112","doi-asserted-by":"publisher","DOI":"10.1042\/bj1800533"},{"key":"2026061519550638000_2026.06.11.731694v1.113","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBABIO.2009.01.005"},{"key":"2026061519550638000_2026.06.11.731694v1.114","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90448-2"},{"key":"2026061519550638000_2026.06.11.731694v1.115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210250200"},{"key":"2026061519550638000_2026.06.11.731694v1.116","doi-asserted-by":"publisher","DOI":"10.1016\/J.FEBSLET.2009.11.031"},{"key":"2026061519550638000_2026.06.11.731694v1.117","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M114.555235"},{"key":"2026061519550638000_2026.06.11.731694v1.118","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-158196"},{"key":"2026061519550638000_2026.06.11.731694v1.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.02.008"},{"key":"2026061519550638000_2026.06.11.731694v1.120","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.6223"},{"key":"2026061519550638000_2026.06.11.731694v1.121","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00024-4"},{"key":"2026061519550638000_2026.06.11.731694v1.122","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204157200"},{"key":"2026061519550638000_2026.06.11.731694v1.123","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.23.7224"},{"key":"2026061519550638000_2026.06.11.731694v1.124","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00112-1"},{"key":"2026061519550638000_2026.06.11.731694v1.125","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80012-X"},{"key":"2026061519550638000_2026.06.11.731694v1.126","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-026-01286-8"},{"key":"2026061519550638000_2026.06.11.731694v1.127","doi-asserted-by":"publisher","DOI":"10.1038\/240217a0"},{"key":"2026061519550638000_2026.06.11.731694v1.128","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80914-9"},{"key":"2026061519550638000_2026.06.11.731694v1.129","doi-asserted-by":"publisher","DOI":"10.1038\/368875a0"},{"key":"2026061519550638000_2026.06.11.731694v1.130","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.308"},{"key":"2026061519550638000_2026.06.11.731694v1.131","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1150"},{"key":"2026061519550638000_2026.06.11.731694v1.132","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.008"},{"key":"2026061519550638000_2026.06.11.731694v1.133","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.17.572088"},{"key":"2026061519550638000_2026.06.11.731694v1.134","doi-asserted-by":"publisher","DOI":"10.1186\/S13059-014-0550-8"},{"key":"2026061519550638000_2026.06.11.731694v1.135","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAF1126"},{"key":"2026061519550638000_2026.06.11.731694v1.136","doi-asserted-by":"publisher","DOI":"10.1093\/BIOINFORMATICS\/BTZ931"},{"key":"2026061519550638000_2026.06.11.731694v1.137","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9236-2_19"},{"key":"2026061519550638000_2026.06.11.731694v1.138","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095"},{"key":"2026061519550638000_2026.06.11.731694v1.139","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAF1117"},{"key":"2026061519550638000_2026.06.11.731694v1.140","doi-asserted-by":"publisher","DOI":"10.1038\/S41587-023-01767-Y"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.11.731694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:55:18Z","timestamp":1781578518000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.11.731694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":140,"URL":"https:\/\/doi.org\/10.64898\/2026.06.11.731694","relation":{},"subject":[],"published":{"date-parts":[[2026,6,12]]},"subtype":"preprint"}}