{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:33:21Z","timestamp":1784774001167,"version":"3.55.0"},"posted":{"date-parts":[[2026,6,12]]},"group-title":"Neuroscience","reference-count":45,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIAAA","award":["1F31AA029273"],"award-info":[{"award-number":["1F31AA029273"]}]},{"name":"NIH\/NIAAA","award":["5P60AA007611"],"award-info":[{"award-number":["5P60AA007611"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Rationale<\/jats:title>\n                  <jats:p>Alcohol use disorder is defined by drinking alcohol despite knowledge of negative consequences, often referred to as aversion-resistant drinking (ARD). The dorsomedial (DMS) and dorsolateral striatum (DLS) are necessary for goal-directed and habitual action selection, respectively. Leading hypotheses posit that once drug use becomes compulsive, DMS dependence degrades while DLS dependence increases. This shift may be mediated by changes in synaptic weights from glutamatergic inputs.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Using a combination of western-blot, micro-injections, and ex-vivo electrophysiology, we investigated the role of \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors AMPAR, which drive glutamatergic transmission, during quinine-adulterated alcohol (QuA) drinking in the DMS and DLS across the development of ARD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that AMPAR subunit composition and function change in the DMS across the development of ARD whereby, calcium permeable (CP) - AMPARs drive behavior. Western blots revealed a negative relationship between DMS GluA1 and QuA drinking in aversion-sensitive mice and positive relationships between DMS or DLS GluA1\/A2 ratios and QuA drinking in ARD mice. DMS CP-AMPAR antagonism caused an increase in QuA drinking suggesting that CP-AMPARs in the DMS prevent ARD. Ex-vivo electrophysiology of DMS spiny projection neurons (SPNs) revealed that ARD mice had a greater rectification index than aversion-sensitive mice indicating that SPNs in the DMS express more CP-AMPARs following the development of ARD.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data provide evidence that repeated alcohol binges alter DMS CP-AMPAR activity, where initial DMS activity acts to prevent ARD but after repeated binges that result in ARD, DMS SPNs recruit CP-AMPARs.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.11.731723","type":"posted-content","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:40:16Z","timestamp":1781336416000},"source":"Crossref","is-referenced-by-count":1,"title":["Dorsomedial Striatum Calcium Permeable AMPA Receptors in the Development of Aversion-Resistant Alcohol Drinking"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-7956","authenticated-orcid":false,"given":"Meredith R.","family":"Bauer","sequence":"first","affiliation":[{"name":"Indiana Alcohol Research Center and Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rangel-Barajas","sequence":"additional","affiliation":[{"name":"Indiana Alcohol Research Center and Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Indiana Alcohol Research Center and Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Stephen L.","family":"Boehm","sequence":"additional","affiliation":[{"name":"Indiana Alcohol Research Center and Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061607052276000_2026.06.11.731723v1.1","unstructured":"American Psychiatric Association 2013. 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