{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:37:40Z","timestamp":1785411460540,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,19]]},"group-title":"Geriatric Medicine","reference-count":59,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"crossref","award":["BF2 - 341333"],"award-info":[{"award-number":["BF2 - 341333"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RGPIN-2022-04409"],"award-info":[{"award-number":["RGPIN-2022-04409"]}],"id":[{"id":"https:\/\/ror.org\/04xrsmr92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Chaire Courtois en recherche fondamentale III"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Brain resilience to tau has been mainly studied in relation to grey matter, while its role in white matter remains unclear in Alzheimer\u2019s disease (AD). Sex may moderate associations between brain resilience and cognition.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We analyzed medial temporal lobe tau PET SUVR, entorhinal cortical thickness, cingulum-hippocampal mean diffusivity, and cognition in 205 amyloid-positive individuals from ADNI. Associations between grey- and white-matter resilience to tau and cognitive performance or decline were examined using linear and mixed-effects models, including sex interactions and stratified analyses.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Higher grey-matter resilience to tau related to better cross-sectional memory and language performance (p&lt;0.005), whereas higher white-matter resilience related to slower decline in these domains (p&lt;0.03). These associations were seen in men but not women. DISCUSSION: White-matter resilience may better capture early cognitive changes in AD. Sex differences suggest greater sensitivity of cognition to brain resilience in men.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.16.26355812","type":"posted-content","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:15:20Z","timestamp":1781892920000},"source":"Crossref","is-referenced-by-count":0,"title":["Grey- and white-matter resilience to tau, cognition and sex in Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6640-5114","authenticated-orcid":false,"given":"S.","family":"Boutin","sequence":"first","affiliation":[{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada, H2V 2T2"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada, H3W 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