{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:26:56Z","timestamp":1785421616066,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,17]]},"group-title":"Biochemistry","reference-count":35,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R35GM118101"],"award-info":[{"award-number":["R35GM118101"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["1ZIA TR000495-01"],"award-info":[{"award-number":["1ZIA TR000495-01"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"crossref","award":["#DGE2241144"],"award-info":[{"award-number":["#DGE2241144"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hans W. Vahlteich Professorship"},{"name":"University of Michigan College of Pharmacy Duellman Graduate Student Research Fund","award":["#PGG030232"],"award-info":[{"award-number":["#PGG030232"]}]},{"name":"Michigan Pioneer Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Premarineosin A undergoes rapid, chemoselective C12 halogenation under mild conditions, providing brominated, chlorinated, fluorinated, and iodinated analogs. These derivatives retained potent antiplasmodial activity against both chloroquine-sensitive and -resistant\n                  <jats:italic>Plasmodium falciparum<\/jats:italic>\n                  strains and displayed smaller reductions in potency against the resistant strain than the parent compound.\n                <\/jats:p>","DOI":"10.64898\/2026.06.16.732709","type":"posted-content","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:00:11Z","timestamp":1781737211000},"source":"Crossref","is-referenced-by-count":0,"title":["Chemoselective Halogenation of Premarineosin A for Next-Generation Antimalarial Development"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-7065","authenticated-orcid":false,"given":"Natalia R.","family":"Harris","sequence":"first","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Amin","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awet A.","family":"Teklemichael","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Dranchak","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, Maryland 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-1525","authenticated-orcid":false,"given":"Christina M.","family":"McBride","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea","family":"Verhey-Henke","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe J.","family":"Warrell","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Dulaney","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin N.","family":"Oliphant","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, Maryland 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-5717","authenticated-orcid":false,"given":"James","family":"Inglese","sequence":"additional","affiliation":[{"name":"National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, Maryland 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3246-3248","authenticated-orcid":false,"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-3647","authenticated-orcid":false,"given":"David H.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA"},{"name":"Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA"},{"name":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026061910251476000_2026.06.16.732709v1.1","doi-asserted-by":"publisher","DOI":"10.1021\/jo5023553"},{"key":"2026061910251476000_2026.06.16.732709v1.2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00560"},{"key":"2026061910251476000_2026.06.16.732709v1.3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00560"},{"key":"2026061910251476000_2026.06.16.732709v1.4","doi-asserted-by":"crossref","first-page":"19755","DOI":"10.1021\/acs.jmedchem.4c02093","article-title":"Optimization of B-Ring-Functionalized Antimalarial Tambjamines and Prodiginines","volume":"67","year":"2024","journal-title":"J. Med. Chem"},{"key":"2026061910251476000_2026.06.16.732709v1.5","doi-asserted-by":"publisher","DOI":"10.1021\/jm200543y"},{"key":"2026061910251476000_2026.06.16.732709v1.6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00517"},{"key":"2026061910251476000_2026.06.16.732709v1.7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00748"},{"key":"2026061910251476000_2026.06.16.732709v1.8","doi-asserted-by":"publisher","DOI":"10.1021\/ja411544w"},{"key":"2026061910251476000_2026.06.16.732709v1.9","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02815-4"},{"key":"2026061910251476000_2026.06.16.732709v1.10","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.2.6.605"},{"key":"2026061910251476000_2026.06.16.732709v1.11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s42004-025-01779-6","article-title":"Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A","volume":"8","year":"2025","journal-title":"Commun. Chem"},{"key":"2026061910251476000_2026.06.16.732709v1.12","unstructured":"World malaria report 2025: Addressing the threat of antimalarial drug resistance."},{"key":"2026061910251476000_2026.06.16.732709v1.13","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-1075-7"},{"key":"2026061910251476000_2026.06.16.732709v1.14","doi-asserted-by":"crossref","unstructured":"O. J. Watson , S. Muchiri , A. Ward , C. Meier-Sherling , V. Asua , T. Katairo , T. Brewer , G. Cuomo-Dannenburg , P. Winskill , J. A. Bailey , L. Okell , G. Scudu and A. M. Woolsey , Risk of selection and timelines for the continued spread of artemisinin and partner drug resistance in Africa, MedRxiv Prepr. Serv. Health Sci., 2024, 2024.08.28.24312699.","DOI":"10.1101\/2024.08.28.24312699"},{"key":"2026061910251476000_2026.06.16.732709v1.15","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.12"},{"key":"2026061910251476000_2026.06.16.732709v1.16","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-253"},{"key":"2026061910251476000_2026.06.16.732709v1.17","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12349"},{"key":"2026061910251476000_2026.06.16.732709v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.12.011"},{"key":"2026061910251476000_2026.06.16.732709v1.19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115546"},{"key":"2026061910251476000_2026.06.16.732709v1.20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41591-024-03439-z","article-title":"Resurgence of malaria and artemisinin resistance in Africa requires a concerted response","volume":"31","year":"2025","journal-title":"Nat. Med"},{"key":"2026061910251476000_2026.06.16.732709v1.21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091397"},{"key":"2026061910251476000_2026.06.16.732709v1.22","doi-asserted-by":"publisher","DOI":"10.1021\/jm3012068"},{"key":"2026061910251476000_2026.06.16.732709v1.23","doi-asserted-by":"crossref","first-page":"13830","DOI":"10.1039\/D6RA01711H","article-title":"Fluorine-containing FDA-approved small-molecule drugs in 2025: significance, synthetic insights, and therapeutic applications","volume":"16","year":"2026","journal-title":"RSC Adv"},{"key":"2026061910251476000_2026.06.16.732709v1.24","doi-asserted-by":"publisher","DOI":"10.1080\/14756360701425014"},{"key":"2026061910251476000_2026.06.16.732709v1.25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131943"},{"key":"2026061910251476000_2026.06.16.732709v1.26","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.tet.2016.03.067","article-title":"Fluorination of pyrrole derivatives by SelectfluorTM","volume":"72","year":"2016","journal-title":"Tetrahedron"},{"key":"2026061910251476000_2026.06.16.732709v1.27","unstructured":"N-Chlorosuccinimide (NCS), https:\/\/www.organic-chemistry.org\/chemicals\/oxidations\/n-chlorosuccinimide-ncs.shtm, (accessed 18 May 2026)."},{"key":"2026061910251476000_2026.06.16.732709v1.28","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1021\/ja5031744","article-title":"Palau\u2019chlor: A Practical and Reactive Chlorinating Reagent","volume":"136","year":"2014","journal-title":"J. Am. Chem. Soc"},{"key":"2026061910251476000_2026.06.16.732709v1.29","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071563"},{"key":"2026061910251476000_2026.06.16.732709v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0349-z"},{"key":"2026061910251476000_2026.06.16.732709v1.31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s42004-023-01083-1","article-title":"Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC","volume":"7","year":"2024","journal-title":"Commun. Chem"},{"key":"2026061910251476000_2026.06.16.732709v1.32","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1016\/j.tet.2006.08.071","article-title":"Pyrrole protection","volume":"62","year":"2006","journal-title":"Tetrahedron"},{"key":"2026061910251476000_2026.06.16.732709v1.33","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1055\/s-2007-990783","article-title":"The Synthesis of Highly Functionalized Pyrroles: A Challenge in Regioselectivity and Chemical Reactivity","volume":"2007","year":"2007","journal-title":"Synthesis"},{"key":"2026061910251476000_2026.06.16.732709v1.34","doi-asserted-by":"crossref","first-page":"118295","DOI":"10.1016\/j.bmc.2025.118295","article-title":"Exploring novel green synthetic pathways and recent advances in pyrrole and its derivatives","volume":"129","year":"2025","journal-title":"Bioorg. Med. Chem"},{"key":"2026061910251476000_2026.06.16.732709v1.35","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.79.178"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.16.732709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:25:27Z","timestamp":1781889927000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.16.732709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":35,"URL":"https:\/\/doi.org\/10.64898\/2026.06.16.732709","relation":{},"subject":[],"published":{"date-parts":[[2026,6,17]]},"subtype":"preprint"}}