{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:21:55Z","timestamp":1791591715819,"version":"4.3.4"},"posted":{"date-parts":[[2026,6,23]]},"group-title":"Neuroscience","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The standard approach to quantify amyloid (A\u03b2) PET averages uptake within a single cortical mask that assumes no clinically relevant spatial heterogeneity in uptake patterns. Here, in a sample of 12,379 clinically impaired participants taken from four phenotypically diverse cohorts we use data-driven approaches to discover heterogeneous patterns of A\u03b2-PET binding, uncovering a reproducible and clinically relevant pattern of posterior predominant A\u03b2-PET binding. In particular, A\u03b2-PET positive participants who have posterior predominant binding are less likely to be\n                  <jats:italic>APOE<\/jats:italic>\n                  -\u03b54 carriers, more severely impaired, have thinner cortex in posterior regions, and greater posterior tau PET burden. Furthermore, in a subsample of participants with neuropathological assessment, participants with posterior predominant A\u03b2 binding have a higher likelihood of having cerebral amyloid angiopathy at autopsy. These findings suggest that A\u03b2-PET accumulates along two orthogonal axes with biological and clinical relevance, indicating that the standard approach to assess A\u03b2-PET is insufficient to capture meaningful signal from A\u03b2-PET imaging. This work has implications for the diagnosis and treatment of Alzheimer\u2019s disease and extends our understanding of the mechanisms governing variable A\u03b2-PET distribution and its downstream effects.\n                <\/jats:p>","DOI":"10.64898\/2026.06.17.733031","type":"posted-content","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:20:18Z","timestamp":1782238818000},"source":"Crossref","is-referenced-by-count":1,"title":["Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-5977","authenticated-orcid":false,"given":"Joseph","family":"Giorgio","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA"},{"name":"School of Psychological Sciences, College of Engineering, Science and the Environment, University of Newcastle, Newcastle, NSW, Australia"},{"name":"Department of Biostatistics, University of California Berkeley, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Blazhenets","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pezzoli","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-2634","authenticated-orcid":false,"given":"Jennifer S.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"},{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Soleimani-Meigooni","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Spina","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N","family":"Nudelman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana G","family":"Apostolova","sequence":"additional","affiliation":[{"name":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford C","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Frontotemporal Disorders Unit and Massachusetts Alzheimer\u2019s Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Jagust","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California Berkeley, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA"},{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud La","family":"Joie","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and 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