{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:01:55Z","timestamp":1785438115982,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,23]]},"group-title":"Neuroscience","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["K08 NS109292"],"award-info":[{"award-number":["K08 NS109292"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>A central goal in translational stroke research is to identify neurophysiological biomarkers that index injury severity and provide information about subsequent functional outcome. Cortical slow oscillations (SOs; 0.1\u20131.0 Hz) are suppressed after ischemic stroke and recover over the following days to weeks. Whether SO recovery actually tracks behavioral recovery, and whether pre-stroke network organization relates to outcome, has not been tested within individual animals. Using longitudinal wide-field calcium imaging in Thy1-GCaMP6f mice (n = 25), we tracked ipsilateral and contralateral SO power across baseline, 24 hours, and one week after photothrombotic stroke of the left somatosensory forepaw cortex, classifying animals by the presence (STI+; n = 14) or absence (STI\u2212; n = 11) of secondary thalamic injury. Acute ipsilateral SO power was suppressed and tracked concurrent behavioral deficit (\u03c1 = \u22120.718, p &lt; 0.001), remaining associated with deficit after adjustment for infarct volume (partial \u03c1 = \u22120.448, p = 0.025). By one week SO power had partially recovered, yet its recovery was dissociated from forelimb use. Week 1 SO power showed no association with behavior in any region or hemisphere (all |\u03c1| \u2264 0.074, all p &gt; 0.5), and SO recovery did not differ significantly between STI groups despite STI+ animals remaining more impaired (p = 0.011). Pre-stroke SO laterality was associated with week 1 behavioral outcome, independent of infarct size (\u03c1 = \u22120.518, p = 0.008; partial \u03c1 = \u22120.446, p = 0.026). Acute SO suppression therefore indexes injury severity beyond infarct volume, whereas spontaneous recovery of SO power is not a reliable surrogate biomarker of week 1 functional outcome. Pre-stroke interhemispheric SO balance emerged as an exploratory candidate source of prognostic information, identifying pre-injury brain state as a dimension that warrants prospective validation.<\/jats:p>","DOI":"10.64898\/2026.06.18.732981","type":"posted-content","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:25:17Z","timestamp":1782253517000},"source":"Crossref","is-referenced-by-count":0,"title":["Slow Oscillations Track Acute Stroke Injury but Not Functional Recovery"],"prefix":"10.64898","author":[{"given":"Jake","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav Ajay","family":"Jadav","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1641","authenticated-orcid":false,"given":"Eric C.","family":"Landsness","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, 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