{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:26:53Z","timestamp":1785403613088,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,20]]},"reference-count":144,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P50CA186786"],"award-info":[{"award-number":["P50CA186786"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,20]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Despite extensive characterization, the molecular determinants that shape disease progression and therapeutic outcomes in metastatic castration-resistant prostate cancer (mCRPC) remain incompletely defined. This large, multi-institutional analysis reveals that the genomic determinants of outcomes in primary prostate cancer are distinct from those in castration-resistant disease. We identify androgen-regulated\n                  <jats:italic>MYC<\/jats:italic>\n                  fusions as potent primary genetic drivers catalyzing early progression. Additionally, across independent mCRPC cohorts, we validate\n                  <jats:italic>TP53, RB1<\/jats:italic>\n                  , and\n                  <jats:italic>CDKN1B<\/jats:italic>\n                  alterations as the strongest genetic drivers of poor survival. Mechanistically,\n                  <jats:italic>CDKN1B<\/jats:italic>\n                  loss induces an AR-positive epithelial\u2013mesenchymal transition rather than neuroendocrine differentiation, while\n                  <jats:italic>TP53<\/jats:italic>\n                  loss triggers whole-genome duplication and subsequent adaptive copy-number gains. Within TP53-altered tumors,\n                  <jats:italic>AR<\/jats:italic>\n                  amplifications confer improved survival while\n                  <jats:italic>AR<\/jats:italic>\n                  mutations are protective regardless of\n                  <jats:italic>TP53<\/jats:italic>\n                  status. Integrating these genomic events with transcriptomic phenotypes, we derive CAPrisk, a multi-omic prognostic classifier. CAPrisk stratifies patients with mCRPC into three risk groups with &gt;33-month survival differences and predicts outcomes across androgen receptor pathway inhibitors, taxanes, PARP-inhibitors, and radium-223. Together, these findings expand the clinical utility of genomic profiling in advanced prostate cancer and establish a framework for risk stratification in lethal disease.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>IN BRIEF (eTOC BLURB)<\/jats:title>\n                  <jats:p>Rebernick et al. analyze a multi-institutional cohort of 1,331 prostate cancer samples and identify the genomic determinants of progression to lethal, castration-resistant disease. They define rare AR-regulated MYC fusions and haploinsufficient CDKN1B loss as drivers of poor outcome while highlighting AR alterations as predictors of improved prognosis. They develop CAPrisk, a multi-omic classifier that stratifies patient outcomes across androgen receptor pathway inhibitors, taxanes, PARP-inhibitors, and radium-223.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>HIGHLIGHTS<\/jats:title>\n                  <jats:list list-type=\"simple\">\n                    <jats:list-item>\n                      <jats:label>\u2013<\/jats:label>\n                      <jats:p>\n                        AR-regulated\n                        <jats:italic>MYC<\/jats:italic>\n                        fusions are rare (\u223c2%) truncal events driving aggressive disease.\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:label>\u2013<\/jats:label>\n                      <jats:p>\n                        Distinct\n                        <jats:italic>AR<\/jats:italic>\n                        alterations drive favorable outcomes in\n                        <jats:italic>TP53<\/jats:italic>\n                        -altered and non-altered contexts.\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:label>\u2013<\/jats:label>\n                      <jats:p>\n                        Haploinsufficient\n                        <jats:italic>CDKN1B<\/jats:italic>\n                        loss predicts poor survival in AR-positive tumors.\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:label>\u2013<\/jats:label>\n                      <jats:p>A multi-omic model predicts outcomes across four standard-of-care therapies.<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>MI-OncoSeq Team<\/jats:title>\n                  <jats:p>Chandan Kumar, Erica Rabban, Kayla Muschong, Lakshmi P. Kunju, Javed Siddiqui, Yu Ning, Rui Wang, Fengyun Su, Yelena Kleyman-Smith, Josh N. Vo, Jin Chen, Rahul Mannan<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Stand Up To Cancer Team<\/jats:title>\n                  <jats:p>Wassim Abida, Joanna Cyrta, Glenn Heller, Davide Prandi, Joshua Armenia, Ilsa Coleman, Matteo Benelli, Eliezer M. Van Allen, Andrea Sboner, Tarcisio Fedrizzi, Juan Miguel Mosquera, Brian D. Robinson, Navonil De Sarkar, Lakshmi P. Kunju, Scott Tomlins, Daniel Nava Rodrigues, Massimo Loda, Anuradha Gopalan, Victor E. Reuter, Colin C. Pritchard, Joaquin Mateo, Diletta Bianchini, Susana Miranda, Suzanne Carreira, Pasquale Rescigno, Julie Filipenko, Jacob Vinson, Robert B. Montgomery, Himisha Beltran, Elisabeth I. Heath, Howard I. Scher, Philip W. Kantoff, Mary-Ellen Taplin, Nikolaus Schultz, Johann S. deBono, Francesca Demichelis, Peter S. Nelson, Mark A. Rubin, Charles Sawyers<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.18.733209","type":"posted-content","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T11:15:15Z","timestamp":1782040515000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate Cancer"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-581X","authenticated-orcid":false,"given":"Ryan J.","family":"Rebernick","sequence":"first","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sheba Medical Center, Ramat Gan, Israel; School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-6758","authenticated-orcid":false,"given":"Mahnoor","family":"Gondal","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Parolia","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"},{"name":"Department of Urology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Mi","family":"Wu","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noshad","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbarasu","family":"Kumaraswamy","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Radiant Oncology, 2450 E River Rd, Tucson, AZ 85718"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Cao","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"},{"name":"Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Palmbos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Caram","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Yentz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MI-OncoSeq Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Stand-Up To Cancer Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha H.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Spratt","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshi J.","family":"Alumkal","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachery","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Robinson","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-3415","authenticated-orcid":false,"given":"Arul M.","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"},{"name":"Department of Urology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dess","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Cieslik","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA"},{"name":"Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026062304001950000_2026.06.18.733209v1.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70043"},{"key":"2026062304001950000_2026.06.18.733209v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00243-0"},{"key":"2026062304001950000_2026.06.18.733209v1.3","unstructured":"National Comprehensive Cancer Network (2024). NCCN Clinical Practice Guidelines in Oncology - Prostate Cancer Version 1.2025. Preprint."},{"key":"2026062304001950000_2026.06.18.733209v1.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"2026062304001950000_2026.06.18.733209v1.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704174"},{"key":"2026062304001950000_2026.06.18.733209v1.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903307"},{"key":"2026062304001950000_2026.06.18.733209v1.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119115"},{"key":"2026062304001950000_2026.06.18.733209v1.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117679"},{"key":"2026062304001950000_2026.06.18.733209v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2166"},{"key":"2026062304001950000_2026.06.18.733209v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.025"},{"key":"2026062304001950000_2026.06.18.733209v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2279"},{"key":"2026062304001950000_2026.06.18.733209v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1347-4"},{"key":"2026062304001950000_2026.06.18.733209v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.034"},{"key":"2026062304001950000_2026.06.18.733209v1.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603144"},{"key":"2026062304001950000_2026.06.18.733209v1.15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5801"},{"key":"2026062304001950000_2026.06.18.733209v1.16","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2023.41.16_suppl.5031"},{"key":"2026062304001950000_2026.06.18.733209v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/nature11125"},{"key":"2026062304001950000_2026.06.18.733209v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0078-z"},{"key":"2026062304001950000_2026.06.18.733209v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902651116"},{"key":"2026062304001950000_2026.06.18.733209v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-021-00490-0"},{"key":"2026062304001950000_2026.06.18.733209v1.21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4199"},{"key":"2026062304001950000_2026.06.18.733209v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4045"},{"key":"2026062304001950000_2026.06.18.733209v1.23","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.70001"},{"key":"2026062304001950000_2026.06.18.733209v1.24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0902"},{"key":"2026062304001950000_2026.06.18.733209v1.25","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.3987"},{"key":"2026062304001950000_2026.06.18.733209v1.26","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0751"},{"key":"2026062304001950000_2026.06.18.733209v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.003"},{"key":"2026062304001950000_2026.06.18.733209v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.039"},{"key":"2026062304001950000_2026.06.18.733209v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.001"},{"key":"2026062304001950000_2026.06.18.733209v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00433-1"},{"key":"2026062304001950000_2026.06.18.733209v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00766-z"},{"key":"2026062304001950000_2026.06.18.733209v1.32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066855"},{"key":"2026062304001950000_2026.06.18.733209v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.021"},{"key":"2026062304001950000_2026.06.18.733209v1.34","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002758"},{"key":"2026062304001950000_2026.06.18.733209v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.02.01"},{"key":"2026062304001950000_2026.06.18.733209v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027"},{"key":"2026062304001950000_2026.06.18.733209v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.07.042"},{"key":"2026062304001950000_2026.06.18.733209v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.06.003"},{"key":"2026062304001950000_2026.06.18.733209v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00805-3"},{"key":"2026062304001950000_2026.06.18.733209v1.40","doi-asserted-by":"publisher","DOI":"10.1200\/PO-25-00341"},{"key":"2026062304001950000_2026.06.18.733209v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2024.10.008"},{"key":"2026062304001950000_2026.06.18.733209v1.42","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6880"},{"key":"2026062304001950000_2026.06.18.733209v1.43","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0593"},{"key":"2026062304001950000_2026.06.18.733209v1.44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315815"},{"key":"2026062304001950000_2026.06.18.733209v1.45","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0937"},{"key":"2026062304001950000_2026.06.18.733209v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/nature23306"},{"key":"2026062304001950000_2026.06.18.733209v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102375"},{"key":"2026062304001950000_2026.06.18.733209v1.48","doi-asserted-by":"publisher","DOI":"10.1200\/PO.17.00029"},{"key":"2026062304001950000_2026.06.18.733209v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.07.009"},{"key":"2026062304001950000_2026.06.18.733209v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.05.005"},{"key":"2026062304001950000_2026.06.18.733209v1.51","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2477"},{"key":"2026062304001950000_2026.06.18.733209v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30257-z"},{"key":"2026062304001950000_2026.06.18.733209v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00197-1"},{"key":"2026062304001950000_2026.06.18.733209v1.54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3441"},{"key":"2026062304001950000_2026.06.18.733209v1.55","doi-asserted-by":"publisher","DOI":"10.3390\/cells9041038"},{"key":"2026062304001950000_2026.06.18.733209v1.56","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01291-6"},{"key":"2026062304001950000_2026.06.18.733209v1.57","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1403"},{"key":"2026062304001950000_2026.06.18.733209v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/nature06024"},{"key":"2026062304001950000_2026.06.18.733209v1.59","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05958-11"},{"key":"2026062304001950000_2026.06.18.733209v1.60","doi-asserted-by":"publisher","DOI":"10.1593\/neo.07822"},{"key":"2026062304001950000_2026.06.18.733209v1.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-020-00137-0"},{"key":"2026062304001950000_2026.06.18.733209v1.62","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22828"},{"key":"2026062304001950000_2026.06.18.733209v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27077-y"},{"key":"2026062304001950000_2026.06.18.733209v1.64","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-22-2228"},{"key":"2026062304001950000_2026.06.18.733209v1.65","doi-asserted-by":"publisher","DOI":"10.1200\/PO-25-00590"},{"key":"2026062304001950000_2026.06.18.733209v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2024.04.011"},{"key":"2026062304001950000_2026.06.18.733209v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.036"},{"key":"2026062304001950000_2026.06.18.733209v1.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.026"},{"key":"2026062304001950000_2026.06.18.733209v1.69","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-3687"},{"key":"2026062304001950000_2026.06.18.733209v1.70","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3403"},{"key":"2026062304001950000_2026.06.18.733209v1.71","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17172862"},{"key":"2026062304001950000_2026.06.18.733209v1.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.03.001"},{"key":"2026062304001950000_2026.06.18.733209v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2821"},{"key":"2026062304001950000_2026.06.18.733209v1.74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-643361"},{"key":"2026062304001950000_2026.06.18.733209v1.75","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2843"},{"key":"2026062304001950000_2026.06.18.733209v1.76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407693101"},{"key":"2026062304001950000_2026.06.18.733209v1.77","doi-asserted-by":"publisher","DOI":"10.1038\/84879"},{"key":"2026062304001950000_2026.06.18.733209v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.06.002"},{"key":"2026062304001950000_2026.06.18.733209v1.79","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.21.13441"},{"key":"2026062304001950000_2026.06.18.733209v1.80","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01347-1"},{"key":"2026062304001950000_2026.06.18.733209v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.06.010"},{"key":"2026062304001950000_2026.06.18.733209v1.82","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128212"},{"key":"2026062304001950000_2026.06.18.733209v1.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107669"},{"key":"2026062304001950000_2026.06.18.733209v1.84","doi-asserted-by":"publisher","DOI":"10.1101\/gr.189621.115"},{"key":"2026062304001950000_2026.06.18.733209v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70295-3"},{"key":"2026062304001950000_2026.06.18.733209v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01055-3"},{"key":"2026062304001950000_2026.06.18.733209v1.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2025.04.012"},{"key":"2026062304001950000_2026.06.18.733209v1.88","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1943"},{"key":"2026062304001950000_2026.06.18.733209v1.89","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03204-2"},{"key":"2026062304001950000_2026.06.18.733209v1.90","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2025.43.5_suppl.403"},{"key":"2026062304001950000_2026.06.18.733209v1.91","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2347"},{"key":"2026062304001950000_2026.06.18.733209v1.92","first-page":"542","article-title":"Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma","volume":"58","year":"1998","journal-title":"Cancer Res"},{"key":"2026062304001950000_2026.06.18.733209v1.93","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63776-5"},{"key":"2026062304001950000_2026.06.18.733209v1.94","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65632-5"},{"key":"2026062304001950000_2026.06.18.733209v1.95","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.916"},{"key":"2026062304001950000_2026.06.18.733209v1.96","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.17.1284"},{"key":"2026062304001950000_2026.06.18.733209v1.97","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2340"},{"key":"2026062304001950000_2026.06.18.733209v1.98","first-page":"2033","article-title":"CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma","volume":"63","year":"2003","journal-title":"Cancer Res"},{"key":"2026062304001950000_2026.06.18.733209v1.99","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0142-8"},{"key":"2026062304001950000_2026.06.18.733209v1.100","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095570"},{"key":"2026062304001950000_2026.06.18.733209v1.101","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-784"},{"key":"2026062304001950000_2026.06.18.733209v1.102","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12881"},{"key":"2026062304001950000_2026.06.18.733209v1.103","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00393"},{"key":"2026062304001950000_2026.06.18.733209v1.104","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx155"},{"key":"2026062304001950000_2026.06.18.733209v1.105","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0869"},{"key":"2026062304001950000_2026.06.18.733209v1.106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.3696"},{"key":"2026062304001950000_2026.06.18.733209v1.107","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06159-4"},{"key":"2026062304001950000_2026.06.18.733209v1.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.004"},{"key":"2026062304001950000_2026.06.18.733209v1.109","unstructured":"GitHub - broadinstitute\/picard: A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) data and formats such as SAM\/BAM\/CRAM and VCF GitHub. https:\/\/github.com\/broadinstitute\/picard."},{"key":"2026062304001950000_2026.06.18.733209v1.110","doi-asserted-by":"publisher","DOI":"10.1186\/s13029-016-0060-z"},{"key":"2026062304001950000_2026.06.18.733209v1.111","unstructured":"Bushnell, B . (2014). BBMap: A Fast, Accurate, Splice-Aware Aligner."},{"key":"2026062304001950000_2026.06.18.733209v1.112","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"2026062304001950000_2026.06.18.733209v1.113","doi-asserted-by":"publisher","DOI":"10.1101\/115717"},{"key":"2026062304001950000_2026.06.18.733209v1.114","doi-asserted-by":"publisher","DOI":"10.1101\/861054"},{"key":"2026062304001950000_2026.06.18.733209v1.115","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0974-4"},{"key":"2026062304001950000_2026.06.18.733209v1.116","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0973-5"},{"key":"2026062304001950000_2026.06.18.733209v1.117","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.12.001"},{"key":"2026062304001950000_2026.06.18.733209v1.118","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxh008"},{"key":"2026062304001950000_2026.06.18.733209v1.119","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2203"},{"key":"2026062304001950000_2026.06.18.733209v1.120","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026062304001950000_2026.06.18.733209v1.121","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"2026062304001950000_2026.06.18.733209v1.122","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw152"},{"key":"2026062304001950000_2026.06.18.733209v1.123","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3578-9_15"},{"key":"2026062304001950000_2026.06.18.733209v1.124","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj037"},{"key":"2026062304001950000_2026.06.18.733209v1.125","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0740-6"},{"key":"2026062304001950000_2026.06.18.733209v1.126","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112965"},{"key":"2026062304001950000_2026.06.18.733209v1.127","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"2026062304001950000_2026.06.18.733209v1.128","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-4-r41"},{"key":"2026062304001950000_2026.06.18.733209v1.129","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49020"},{"key":"2026062304001950000_2026.06.18.733209v1.130","unstructured":"Kassambara, A. , Kosinski, M. , Biecek, P. , and Scheipl, F . (2021). Drawing Survival Curves using \u201cggplot2\u201d [R package survminer version 0.4.9]."},{"key":"2026062304001950000_2026.06.18.733209v1.131","unstructured":"Therneau, T.M. Survival Analysis [R package survival version 3.3-1]."},{"key":"2026062304001950000_2026.06.18.733209v1.132","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2022.01.001"},{"key":"2026062304001950000_2026.06.18.733209v1.133","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"2026062304001950000_2026.06.18.733209v1.134","doi-asserted-by":"crossref","unstructured":"Dolgalev, I. (2022). MSigDB Gene Sets for Multiple Organisms in a Tidy Data Format [R package msigdbr version 7.5.1].","DOI":"10.32614\/CRAN.package.babelgene"},{"key":"2026062304001950000_2026.06.18.733209v1.135","doi-asserted-by":"publisher","DOI":"10.1101\/060012"},{"key":"2026062304001950000_2026.06.18.733209v1.136","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"2026062304001950000_2026.06.18.733209v1.137","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2435-4"},{"key":"2026062304001950000_2026.06.18.733209v1.138","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v069.i01"},{"key":"2026062304001950000_2026.06.18.733209v1.139","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0275"},{"key":"2026062304001950000_2026.06.18.733209v1.140","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24269"},{"key":"2026062304001950000_2026.06.18.733209v1.141","unstructured":"Li, B. , and Ruilin, N. msisensor2: Microsatellite instability (MSI) detection for tumor only data (Github)."},{"key":"2026062304001950000_2026.06.18.733209v1.142","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3729-z"},{"key":"2026062304001950000_2026.06.18.733209v1.143","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.167440"},{"key":"2026062304001950000_2026.06.18.733209v1.144","doi-asserted-by":"publisher","DOI":"10.1126\/science.adv2367"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.18.733209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:10:58Z","timestamp":1782213058000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.18.733209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":144,"URL":"https:\/\/doi.org\/10.64898\/2026.06.18.733209","relation":{},"subject":[],"published":{"date-parts":[[2026,6,20]]},"subtype":"preprint"}}