{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:56:57Z","timestamp":1785430617165,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,23]]},"group-title":"Neuroscience","reference-count":106,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["AG 073622"],"award-info":[{"award-number":["AG 073622"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>MicroRNAs (miRNA), are non-coding RNA that act as post-transcriptional regulators of gene expression in various organs including the brain where they play an important role in neurodegeneration. Circular RNAs are single-stranded, covalently closed loop RNA molecules recognized as upstream regulators of miRNA. Previous studies have shown that circRNAs are dysregulated in Alzheimer\u2019s and other neurodegenerative diseases. However, a systematic, age-and region-specific circRNA atlas in primary tauopathy is lacking.<\/jats:p>\n                <jats:p>To this end, we performed comprehensive circRNA sequencing of hippocampal and cortical tissues from a model of human tauopathy, h-Tau mice, at 3, 6, and 12 months of age. We identified circRNA\u2013miRNA sponging networks that target and regulate key tau disease-associated pathways, including kinases, phosphatases, histone deacetylase, glutamatergic and GABAergic synapse, and microglial efferocytosis.<\/jats:p>\n                <jats:p>Our study demonstrates an age- and region-specific circRNA landscape in the brain of a model of human tauopathy and identify candidate circRNA\u2013miRNA\u2013mRNA regulatory axes converging on core tau pathological processes. These findings support the novel hypothesis that specific circRNAs have the potential to be used as biomarkers and therapeutic targets against tau-driven neurodegeneration.<\/jats:p>","DOI":"10.64898\/2026.06.18.733253","type":"posted-content","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:24:59Z","timestamp":1782228299000},"source":"Crossref","is-referenced-by-count":0,"title":["Temporal and Regional Circular RNA profiling in a Tauopathy Mouse Model: Implications for Tau Pathology and Neurodegeneration"],"prefix":"10.64898","author":[{"given":"Mohammad Shahadat","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pratic\u00f2","sequence":"additional","affiliation":[{"name":"Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026062423352124000_2026.06.18.733253v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"2026062423352124000_2026.06.18.733253v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.04.016"},{"key":"2026062423352124000_2026.06.18.733253v1.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2026062423352124000_2026.06.18.733253v1.4","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-53"},{"key":"2026062423352124000_2026.06.18.733253v1.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02879-2"},{"key":"2026062423352124000_2026.06.18.733253v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3710"},{"key":"2026062423352124000_2026.06.18.733253v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13784"},{"key":"2026062423352124000_2026.06.18.733253v1.8","doi-asserted-by":"crossref","first-page":"eads7509","DOI":"10.1126\/sciadv.ads7509","article-title":"Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs","volume":"12","year":"2026","journal-title":"Sci Adv"},{"key":"2026062423352124000_2026.06.18.733253v1.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322360111"},{"key":"2026062423352124000_2026.06.18.733253v1.10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bbadis.2014.01.004","article-title":"Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2","volume":"1842","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2026062423352124000_2026.06.18.733253v1.11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01208"},{"key":"2026062423352124000_2026.06.18.733253v1.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2414176121"},{"key":"2026062423352124000_2026.06.18.733253v1.13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12974-025-03428-0","article-title":"Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer\u2019s disease","volume":"22","year":"2025","journal-title":"J Neuroinflammation"},{"key":"2026062423352124000_2026.06.18.733253v1.14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00122"},{"key":"2026062423352124000_2026.06.18.733253v1.15","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00476-x"},{"key":"2026062423352124000_2026.06.18.733253v1.16","doi-asserted-by":"publisher","DOI":"10.1186\/S13195-020-00588-4"},{"key":"2026062423352124000_2026.06.18.733253v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.033"},{"key":"2026062423352124000_2026.06.18.733253v1.18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"2026062423352124000_2026.06.18.733253v1.19","doi-asserted-by":"crossref","first-page":"894938","DOI":"10.4061\/2011\/894938","article-title":"MicroRNAs and Alzheimer\u2019s Disease Mouse Models: Current Insights and Future Research Avenues","volume":"2011","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"2026062423352124000_2026.06.18.733253v1.20","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090157"},{"key":"2026062423352124000_2026.06.18.733253v1.21","doi-asserted-by":"crossref","first-page":"18509","DOI":"10.1038\/s41598-019-54782-y","article-title":"Investigating the energy crisis in Alzheimer disease using transcriptome study","volume":"9","year":"2019","journal-title":"Sci Rep"},{"key":"2026062423352124000_2026.06.18.733253v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.021"},{"key":"2026062423352124000_2026.06.18.733253v1.23","doi-asserted-by":"crossref","unstructured":"Dong, X. , et al., 2023. Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. bioRxiv.","DOI":"10.1101\/2023.04.01.535194"},{"key":"2026062423352124000_2026.06.18.733253v1.24","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05272.x"},{"key":"2026062423352124000_2026.06.18.733253v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0501-5"},{"key":"2026062423352124000_2026.06.18.733253v1.26","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14366"},{"key":"2026062423352124000_2026.06.18.733253v1.27","doi-asserted-by":"crossref","unstructured":"Fiock, K. L. , et al., 2020. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. 7.","DOI":"10.1523\/ENEURO.0058-20.2020"},{"key":"2026062423352124000_2026.06.18.733253v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0221-2"},{"key":"2026062423352124000_2026.06.18.733253v1.29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13041-025-01262-2","article-title":"Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson\u2019s disease","volume":"19","year":"2025","journal-title":"Mol Brain"},{"key":"2026062423352124000_2026.06.18.733253v1.30","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0571-3"},{"key":"2026062423352124000_2026.06.18.733253v1.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03552.x"},{"key":"2026062423352124000_2026.06.18.733253v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90400-6"},{"key":"2026062423352124000_2026.06.18.733253v1.33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65020732.x"},{"key":"2026062423352124000_2026.06.18.733253v1.34","doi-asserted-by":"crossref","first-page":"e70977","DOI":"10.1002\/alz.70977","article-title":"Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo-lysosomal dysfunction","volume":"21","year":"2025","journal-title":"Alzheimers Dement"},{"key":"2026062423352124000_2026.06.18.733253v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature10849"},{"key":"2026062423352124000_2026.06.18.733253v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/nature07925"},{"key":"2026062423352124000_2026.06.18.733253v1.37","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013551"},{"key":"2026062423352124000_2026.06.18.733253v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.01.003"},{"key":"2026062423352124000_2026.06.18.733253v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"2026062423352124000_2026.06.18.733253v1.40","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1000"},{"key":"2026062423352124000_2026.06.18.733253v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.12.003"},{"key":"2026062423352124000_2026.06.18.733253v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0483-4"},{"key":"2026062423352124000_2026.06.18.733253v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.225"},{"key":"2026062423352124000_2026.06.18.733253v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1769-z"},{"key":"2026062423352124000_2026.06.18.733253v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.036"},{"key":"2026062423352124000_2026.06.18.733253v1.46","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1093\/brain\/awaf222","article-title":"Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer\u2019s disease","volume":"148","year":"2025","journal-title":"Brain"},{"key":"2026062423352124000_2026.06.18.733253v1.47","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1177\/1535370221999812","article-title":"Cytosolic protein quality control machinery: Interactions of Hsp70 with a network of co-chaperones and substrates","volume":"246","year":"2021","journal-title":"Exp Biol Med (Maywood"},{"key":"2026062423352124000_2026.06.18.733253v1.48","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1038\/s41467-025-58070-4","article-title":"A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons","volume":"16","year":"2025","journal-title":"Nat Commun"},{"key":"2026062423352124000_2026.06.18.733253v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10682"},{"key":"2026062423352124000_2026.06.18.733253v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"2026062423352124000_2026.06.18.733253v1.51","doi-asserted-by":"crossref","unstructured":"Kulczynska-Przybik, A. , et al., 2021. The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases. J Clin Med. 10.","DOI":"10.3390\/jcm10225281"},{"key":"2026062423352124000_2026.06.18.733253v1.52","doi-asserted-by":"crossref","first-page":"7020","DOI":"10.1038\/s41380-020-0655-2","article-title":"Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis","volume":"26","year":"2021","journal-title":"Mol Psychiatry"},{"key":"2026062423352124000_2026.06.18.733253v1.53","doi-asserted-by":"crossref","unstructured":"Lee, J. K. , Kim, N. J ., 2017. Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer\u2019s Disease. Molecules. 22.","DOI":"10.3390\/molecules22081287"},{"key":"2026062423352124000_2026.06.18.733253v1.54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/2051-5960-1-34","article-title":"Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments","volume":"1","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"2026062423352124000_2026.06.18.733253v1.55","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12943-025-02484-7","article-title":"Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy","volume":"24","year":"2025","journal-title":"Mol Cancer"},{"key":"2026062423352124000_2026.06.18.733253v1.56","first-page":"102035","article-title":"Identification of GABBR2 as a diagnostic marker and its association with Abeta in Alzheimer\u2019s disease","volume":"42","year":"2025","journal-title":"Biochem Biophys Rep"},{"key":"2026062423352124000_2026.06.18.733253v1.57","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-3-8"},{"key":"2026062423352124000_2026.06.18.733253v1.58","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026062423352124000_2026.06.18.733253v1.59","doi-asserted-by":"crossref","first-page":"102631","DOI":"10.1016\/j.xcrm.2026.102631","article-title":"Neuronal PPP2R5C in plasma is a potential biomarker for early diagnosis of Alzheimer\u2019s disease","volume":"7","year":"2026","journal-title":"Cell Rep Med"},{"key":"2026062423352124000_2026.06.18.733253v1.60","doi-asserted-by":"crossref","unstructured":"Majumder, M. , Dutta, D ., 2024. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. 13.","DOI":"10.3390\/cells13131112"},{"key":"2026062423352124000_2026.06.18.733253v1.61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/bs.irn.2020.01.006","article-title":"Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer\u2019s disease: Amelioration by metabolic switching","volume":"154","year":"2020","journal-title":"Int Rev Neurobiol"},{"key":"2026062423352124000_2026.06.18.733253v1.62","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13000"},{"key":"2026062423352124000_2026.06.18.733253v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"2026062423352124000_2026.06.18.733253v1.64","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29409"},{"key":"2026062423352124000_2026.06.18.733253v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"2026062423352124000_2026.06.18.733253v1.66","doi-asserted-by":"crossref","first-page":"10813","DOI":"10.1038\/s41598-023-37887-3","article-title":"Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis","volume":"13","year":"2023","journal-title":"Sci Rep"},{"key":"2026062423352124000_2026.06.18.733253v1.67","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-016-0292-9","article-title":"Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy","volume":"4","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"2026062423352124000_2026.06.18.733253v1.68","doi-asserted-by":"crossref","unstructured":"Piwecka, M. , et al., 2017. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science. 357.","DOI":"10.1126\/science.aam8526"},{"key":"2026062423352124000_2026.06.18.733253v1.69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr195"},{"key":"2026062423352124000_2026.06.18.733253v1.70","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1411-2"},{"key":"2026062423352124000_2026.06.18.733253v1.71","doi-asserted-by":"crossref","first-page":"e00353","DOI":"10.1016\/j.neurot.2024.e00353","article-title":"Regulating Lars2 in mitochondria: A potential Alzheimer\u2019s therapy by inhibiting tau phosphorylation","volume":"21","year":"2024","journal-title":"Neurotherapeutics"},{"key":"2026062423352124000_2026.06.18.733253v1.72","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0324-9"},{"key":"2026062423352124000_2026.06.18.733253v1.73","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"2026062423352124000_2026.06.18.733253v1.74","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0549"},{"key":"2026062423352124000_2026.06.18.733253v1.75","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3233\/JAD-150429","article-title":"Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer\u2019s Disease Pathology","volume":"49","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"2026062423352124000_2026.06.18.733253v1.76","first-page":"79","article-title":"Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer\u2019s disease correlates with pathology","volume":"2","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"2026062423352124000_2026.06.18.733253v1.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101644"},{"key":"2026062423352124000_2026.06.18.733253v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.03.027"},{"key":"2026062423352124000_2026.06.18.733253v1.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"2026062423352124000_2026.06.18.733253v1.80","doi-asserted-by":"crossref","unstructured":"Sayas, C. L. , Avila, J ., 2021. GSK-3 and Tau: A Key Duet in Alzheimer\u2019s Disease. Cells. 10.","DOI":"10.3390\/cells10040721"},{"key":"2026062423352124000_2026.06.18.733253v1.81","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260698.46517.8f"},{"key":"2026062423352124000_2026.06.18.733253v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2019.01.001"},{"key":"2026062423352124000_2026.06.18.733253v1.83","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"2026062423352124000_2026.06.18.733253v1.84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.204453"},{"key":"2026062423352124000_2026.06.18.733253v1.85","doi-asserted-by":"crossref","first-page":"100128","DOI":"10.1016\/j.pharmr.2026.100128","article-title":"Targeting of kinases to treat neurodegenerative diseases","volume":"78","year":"2026","journal-title":"Pharmacol Rev"},{"key":"2026062423352124000_2026.06.18.733253v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102509"},{"key":"2026062423352124000_2026.06.18.733253v1.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.09.005"},{"key":"2026062423352124000_2026.06.18.733253v1.88","first-page":"16","article-title":"Protein phosphatase 2A dysfunction in Alzheimer\u2019s disease","volume":"7","year":"2014","journal-title":"Front Mol Neurosci"},{"key":"2026062423352124000_2026.06.18.733253v1.89","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70090-5"},{"key":"2026062423352124000_2026.06.18.733253v1.90","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44370"},{"key":"2026062423352124000_2026.06.18.733253v1.91","doi-asserted-by":"crossref","first-page":"15583","DOI":"10.1038\/s41598-020-72638-8","article-title":"Dysregulation of metabolic pathways by carnitine palmitoyl-transferase 1 plays a key role in central nervous system disorders: experimental evidence based on animal models","volume":"10","year":"2020","journal-title":"Sci Rep"},{"key":"2026062423352124000_2026.06.18.733253v1.92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422001112"},{"key":"2026062423352124000_2026.06.18.733253v1.93","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40478-019-0754-y","article-title":"Intersection of pathological tau and microglia at the synapse","volume":"7","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"2026062423352124000_2026.06.18.733253v1.94","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4360"},{"key":"2026062423352124000_2026.06.18.733253v1.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.09.052"},{"key":"2026062423352124000_2026.06.18.733253v1.96","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0102"},{"key":"2026062423352124000_2026.06.18.733253v1.97","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29552-6"},{"key":"2026062423352124000_2026.06.18.733253v1.98","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-21.2021"},{"key":"2026062423352124000_2026.06.18.733253v1.99","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70048"},{"key":"2026062423352124000_2026.06.18.733253v1.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.08.006"},{"key":"2026062423352124000_2026.06.18.733253v1.101","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.112"},{"key":"2026062423352124000_2026.06.18.733253v1.102","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5115\/acb.2010.43.4.332","article-title":"Expression of ErbB4 in the apoptotic neurons of Alzheimer\u2019s disease brain","volume":"43","year":"2010","journal-title":"Anat Cell Biol"},{"key":"2026062423352124000_2026.06.18.733253v1.103","first-page":"143269","article-title":"Targeting HDACs: a promising therapy for Alzheimer\u2019s disease","volume":"2011","year":"2011","journal-title":"Oxid Med Cell Longev"},{"key":"2026062423352124000_2026.06.18.733253v1.104","doi-asserted-by":"crossref","first-page":"9240","DOI":"10.7150\/thno.118409","article-title":"Targeted autophagic clearance of Tau protects against Alzheimer\u2019s disease through amelioration of Tau-mediated lysosomal stress","volume":"15","year":"2025","journal-title":"Theranostics"},{"key":"2026062423352124000_2026.06.18.733253v1.105","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3975"},{"key":"2026062423352124000_2026.06.18.733253v1.106","doi-asserted-by":"crossref","first-page":"773344","DOI":"10.3389\/fcell.2021.773344","article-title":"Efferocytosis in the Central Nervous System","volume":"9","year":"2021","journal-title":"Front Cell Dev Biol"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.18.733253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:35:46Z","timestamp":1782369346000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.18.733253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":106,"URL":"https:\/\/doi.org\/10.64898\/2026.06.18.733253","relation":{},"subject":[],"published":{"date-parts":[[2026,6,23]]},"subtype":"preprint"}}