{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:47:37Z","timestamp":1782316057215,"version":"3.54.5"},"posted":{"date-parts":[[2026,6,22]]},"group-title":"Neurology","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["2T32HD007414"],"award-info":[{"award-number":["2T32HD007414"]}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["P50 DC014664"],"award-info":[{"award-number":["P50 DC014664"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["R01 DC05375"],"award-info":[{"award-number":["R01 DC05375"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","award":["P41 EB031771"],"award-info":[{"award-number":["P41 EB031771"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","award":["1S10OD021648"],"award-info":[{"award-number":["1S10OD021648"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Western Aphasia Battery-Revised (WAB-R) Aphasia Quotient is the most widely used standardized post-stroke aphasia measure; its conventional 93.8 cutoff has limited sensitivity to mild residual impairment. Beyond the cutoff, it offers limited objective discourse assessment, no action-naming assessment, and naming tests limited to very common objects.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We sought short tests capturing subtle aphasia in patients recovered above the WAB-R threshold, then its demographic and lesion correlates.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods &amp; Procedures<\/jats:title>\n                  <jats:p>Sixty-seven patients with acute left-hemisphere ischemic stroke completed acute structural MRI and a 12-month language battery comprising the WAB-R, Boston Naming Test (BNT), Hopkins Action Naming Assessment (HANA), and Modern Cookie Theft (MCT) picture description. Hierarchical logistic (binary deficit) and linear (control-referenced composite z-score) regressions evaluated acute aphasia history, sex, education, age, acute depression (PHQ-9), and residualized regional lesion load.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Outcomes &amp; Results<\/jats:title>\n                  <jats:p>Of 67 participants, 45 (67%) recovered above the WAB-R threshold. Of these, 18 (40%) had residual deficits on at least one supplemental test (\u201csubtle aphasia\u201d). BNT plus MCT content-unit count captured all 18 (100%); HANA added none beyond these two. The binary model discriminated deficit from no-deficit at AUC = 0.80 (95% CI [0.70, 1.00]); higher education significantly lowered deficit odds (OR = 0.80\/year, 95% CI [0.64, 1.00], p = .049). On the continuous composite, acute PHQ-9 independently predicted 12-month outcome (\u03b2 = \u22120.13 per point, 95% CI [\u22120.22, \u22120.04], p = .006, cumulative R\u00b2 = 0.38). Applying the Senthilkumar et al. (2026) stricter cutoff (WAB-AQ \u2265 96.7) reclassified 12 of 45 (27%) out of recovery, capturing 8 of 18 (44%) subtle-aphasia patients. Composite residualized lesion load did not differentiate the groups when adjusted.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Above the WAB-R recovery threshold, subtle aphasia is present on the BNT or MCT in \u223c40%, with higher education associated with lower odds at 12 months; acute depression emerged as a candidate correlate but did not survive removal of a single high-influence observation, warranting replication in larger samples. Regional lesion variables informative at greater stroke severity contribute little as large lesions cluster in the persistently aphasic group, reducing lesion variance within the recovered subgroup and its discrimination of subtle deficits. This adds to evidence that clinicians should not infer complete language recovery from the WAB-AQ alone, and that identifying residual deficits may require greater investment in behavioral assessment and consideration of alternative WAB-AQ cutoffs. Structural anatomical information, by contrast, appears to add little discriminative value at the upper performance range.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.19.26356022","type":"posted-content","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:25:13Z","timestamp":1782167113000},"source":"Crossref","is-referenced-by-count":0,"title":["Subtle language deficits in WAB-recovered patients at 12 months after left-hemisphere stroke"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-601X","authenticated-orcid":false,"given":"Manuel Jose","family":"Marte","sequence":"first","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Chaves","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Krieger School of Arts and Sciences, Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidora","family":"Diaz-Carr","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voss","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia V.","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Stockbridge","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"},{"name":"Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argye E.","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cerebrovascular Division, Johns Hopkins University School of Medicine"},{"name":"Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine"},{"name":"Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins 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