{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:00:53Z","timestamp":1785427253140,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,24]]},"group-title":"Immunology","reference-count":54,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["P30CA023108"],"award-info":[{"award-number":["P30CA023108"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["S10OD030242"],"award-info":[{"award-number":["S10OD030242"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P20GM130454"],"award-info":[{"award-number":["P20GM130454"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["S10OD025235"],"award-info":[{"award-number":["S10OD025235"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01CA22502"],"award-info":[{"award-number":["R01CA22502"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01CA254042"],"award-info":[{"award-number":["R01CA254042"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020431","name":"Dartmouth Cancer Center","doi-asserted-by":"crossref","award":["The Nelson Andrea Clark Medical Research fund"],"award-info":[{"award-number":["The Nelson Andrea Clark Medical Research fund"]}],"id":[{"id":"10.13039\/100020431","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020431","name":"Dartmouth Cancer Center","doi-asserted-by":"crossref","award":["The Anderson Charles H Cancer Research Fund"],"award-info":[{"award-number":["The Anderson Charles H Cancer Research Fund"]}],"id":[{"id":"10.13039\/100020431","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020431","name":"Dartmouth Cancer Center","doi-asserted-by":"crossref","award":["ICI COMPEL award"],"award-info":[{"award-number":["ICI COMPEL award"]}],"id":[{"id":"10.13039\/100020431","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Across cancers, tumor-infiltrating CD8+ T cells expressing the tissue-resident memory T cell (T\n                  <jats:sub>RM<\/jats:sub>\n                  ) markers CD69 and CD103 are strongly associated with favorable clinical outcomes. However, a substantial fraction of these cells in human tumors are not tumor-specific, but instead recognize unrelated viral antigens. These virus-specific bystander T\n                  <jats:sub>RM<\/jats:sub>\n                  -like cells are prevalent in tumors and retain functional potential, raising interest in strategies that leverage pre-existing antiviral immunity for cancer immunotherapy. Yet their origins and differentiation states remain poorly defined, limiting both the interpretation of residency-based tumor-infiltrating lymphocyte (TIL) phenotyping and efforts to rationally harness these T\n                  <jats:sub>RM<\/jats:sub>\n                  -like cells. Here, using mouse models of GBM and melanoma, we demonstrate that resting circulating memory T cells trafficked into tumors via GPCR-dependent signaling and rapidly adopted a tissue-resident phenotype, independent of cognate antigen. Strikingly, in GBM, but not melanoma, pre-existing brain T\n                  <jats:sub>RM<\/jats:sub>\n                  contributed substantially to the bystander TIL compartment and were the dominant source of CD69+\/CD103+ bystander T cells, revealing a tumor- and tissue-specific origin for this subset. These findings were further supported by transcriptional analysis of T cell receptor clones present in both paired patient GBM tumor and peritumoral brain, which identified shared features with T\n                  <jats:sub>RM<\/jats:sub>\n                  -derived TILs in mouse GBM. Overall, this work provides new insight into tumor immunosurveillance, inform the interpretation of CD69+\/CD103- and CD103+ TIL populations, and lay a foundation for immunotherapeutic strategies aimed at harnessing circulating and pre-existing virus-specific T\n                  <jats:sub>RM<\/jats:sub>\n                  populations in tumors.\n                <\/jats:p>","DOI":"10.64898\/2026.06.19.733403","type":"posted-content","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:10:11Z","timestamp":1782342611000},"source":"Crossref","is-referenced-by-count":0,"title":["Circulating and brain-resident memory CD8+ T cells seed distinct bystander T\n                  <sub>RM<\/sub>\n                  -like populations in glioblastoma"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-4514","authenticated-orcid":false,"given":"Sierra A.","family":"Kleist","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn C.","family":"Musial","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neva R.","family":"DiBlasi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna N.","family":"Degefu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles A.","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan F.","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cruz Rivera","sequence":"additional","affiliation":[{"name":"Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Department of Neurology, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle J.","family":"Sclar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Department of Neurology, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina V.","family":"Angeles","sequence":"additional","affiliation":[{"name":"Rogel Cancer Center, Department of Surgery\/Division of Surgical Oncology, Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linton T.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sladjana","family":"Skopelja-Gardner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Dartmouth Cancer Center, Lebanon, NH"},{"name":"Department of Medicine, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Dartmouth Cancer Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G. J.","family":"Skorput","sequence":"additional","affiliation":[{"name":"Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Department of Neurology, Dartmouth Health, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia M.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela C.","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH"},{"name":"Dartmouth Cancer Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026062609451273000_2026.06.19.733403v1.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053214"},{"key":"2026062609451273000_2026.06.19.733403v1.2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101320-020220"},{"key":"2026062609451273000_2026.06.19.733403v1.3","first-page":"1734","article-title":"Resident memory T cells and cancer","volume":"57","year":"2024","journal-title":"Immunity. 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