{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:09:36Z","timestamp":1787652576476,"version":"build-2736575974"},"posted":{"date-parts":[[2026,6,23]]},"group-title":"Bioengineering","reference-count":68,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institutes of Health BRAIN Initiative","award":["UG3NS123135-01A1"],"award-info":[{"award-number":["UG3NS123135-01A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Whether proprioception is necessary for upper-limb motor control has been debated for decades. Classic studies in deafferented animals and humans suggested that proprioception may be dispensable for rapid, goal-directed movements. However, chronic sensory loss conflates the absence of proprioceptive input with years of compensatory adaptation. As a result, the field has lacked a strong causal test of proprioception\u2019s contribution to motor control. Here, we leveraged a clinical trial of cervical spinal cord stimulation (SCS) in individuals with chronic post-stroke hemiparesis to study if electrical stimulation of sensory afferents causally perturbs proprioception and affects arm reaching. We found that turning SCS ON causally impaired proprioceptive perception and postural stabilization in response to force perturbations, and enhanced adaptation to visual errors during implicit learning. Yet visually and non-visually rapid, goal-directed reaching improved in smoothness, straightness and spatial accuracy. These findings provide strong causal evidence that proprioception is not required for rapid, goal-directed action, helping resolve a decades-long debate regarding its necessity for effective movement.<\/jats:p>","DOI":"10.64898\/2026.06.20.733548","type":"posted-content","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:10:34Z","timestamp":1782213034000},"source":"Crossref","is-referenced-by-count":1,"title":["Cervical spinal cord stimulation disrupts proprioception yet improves voluntary arm reaching"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-3222","authenticated-orcid":false,"given":"Erick","family":"Carranza","sequence":"first","affiliation":[{"name":"Rehabilitation and Neural Engineering Labs (RNEL), University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Center for the Neural Basis of Cognition (CNBC), Pittsburgh, PA, 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