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Mechanistically, Evolocumab immunomodulates macrophage reprogramming to enhance clearance of apoptotic smooth muscle cells via MerTK-dependent efferocytosis that ameliorates aortic inflammation and vascular remodeling. Furthermore, Evolocumab increases the expression of oxidized phosphatidylserine species and decreases expression of lysophospholipids, succinate, and glycolytic intermediates within the aortic wall compared to untreated controls, further enhancing the pro-resolving functions of macrophages. Collectively, our data demonstrates the ability of PCSK9 inhibition to regulate macrophage-specific efferocytosis that limits AAA progression and prevents aortic rupture.<\/jats:p>","DOI":"10.64898\/2026.06.22.733861","type":"posted-content","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:10:24Z","timestamp":1782562224000},"source":"Crossref","is-referenced-by-count":0,"title":["Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition attenuates abdominal aortic aneurysm formation via enhanced macrophage-dependent efferocytosis"],"prefix":"10.64898","author":[{"given":"Michael J.","family":"Fassler","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinthan","family":"Adithan","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff Arni C.","family":"Valisno","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Viscardi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffin","family":"Stinson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn S.","family":"Gillies","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walker R.","family":"Ueland","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiven","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Florida, Gainesville, FL, 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-1850","authenticated-orcid":false,"given":"Ramon","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Florida, Gainesville, FL, 32610, USA"},{"name":"Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, 32610, USA"},{"name":"Evelyn F. and William L. 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