{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:01:25Z","timestamp":1785420085117,"version":"3.56.0"},"posted":{"date-parts":[[2026,6,25]]},"group-title":"Neurology","reference-count":20,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R00AG075238, M.E.B"],"award-info":[{"award-number":["R00AG075238, M.E.B"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Parkinson\u2019s disease (PD) exhibits pronounced sex differences, yet the underlying genetic and molecular mechanisms remain poorly understood. We performed the largest-to-date meta-analysis of sex-stratified genome-wide association studies of PD followed by brain proteogenomics-based causal inference analyses. We nominated 10 candidate proteins that appear important to sex-biased PD risk, of which 2 female-biased, GALC and PSMG1, and 3 male-biased, ACTR1B, WDR41, and CD151, were most robustly prioritized. Together, our findings provide evidence for genetic sex differences in PD, prioritizing sex-biased proteins implicated in lysosomal regulation, neuroinflammation, lipid biology, and other PD-relevant mechanisms, and highlighting potential sex-informed therapeutic opportunities.<\/jats:p>","DOI":"10.64898\/2026.06.23.26356345","type":"posted-content","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:05:18Z","timestamp":1782432318000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-biased Genetic Risk Loci and Causal Brain Proteins in Parkinson\u2019s Disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7906-5924","authenticated-orcid":false,"given":"Noah","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 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