{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:24:18Z","timestamp":1790223858274,"version":"4.1.0"},"posted":{"date-parts":[[2026,6,25]]},"group-title":"Genetic and Genomic Medicine","reference-count":50,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["058299\/Z\/99"],"award-info":[{"award-number":["058299\/Z\/99"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["RE\/13\/1\/30181"],"award-info":[{"award-number":["RE\/13\/1\/30181"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MC_UU_00017\/2"],"award-info":[{"award-number":["MC_UU_00017\/2"]}]},{"name":"Medical Research Council","award":["MR\/Z504543\/1"],"award-info":[{"award-number":["MR\/Z504543\/1"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL142302"],"award-info":[{"award-number":["R01HL142302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,25]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Type 2 diabetes (T2D) is a highly heritable, polygenic disease with over 600 loci identified through genome-wide association studies (GWAS). However, despite possessing unique genetic variation shaped by demographic history and admixture, Latin American populations remain markedly underrepresented in global genomic research. To address this gap, we conducted genome- and exome-wide analyses of 19,431 T2D cases and 105,611 controls from the Mexico City Prospective Study (MCPS). We identified 86 independent GWAS associations, including 21 novel signals, 15 of which replicated in external cohorts. Risk alleles at novel loci were enriched in individuals with Indigenous American ancestry. Exome analyses revealed rare and ultra-rare missense variants with substantial risk effects at\n                  <jats:italic>HNF1A<\/jats:italic>\n                  and\n                  <jats:italic>GCK<\/jats:italic>\n                  , as well as a protein-damaging variant in\n                  <jats:italic>SLC30A8<\/jats:italic>\n                  that reduced T2D risk by 45% in carriers. Integrative analyses indicate that T2D genetic architecture in Mexico is predominantly driven by common regulatory variation acting in the endocrine pancreas. Polygenic risk scores strongly stratified T2D risk and transferred to Indigenous Mexican populations. These findings demonstrate the power of large-scale genetic discovery in diverse populations to refine disease architecture and identify loci with potential therapeutic relevance.\n                <\/jats:p>","DOI":"10.64898\/2026.06.23.26356360","type":"posted-content","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:05:41Z","timestamp":1782432341000},"source":"Crossref","is-referenced-by-count":1,"title":["Type 2 diabetes genetics in 125,000 admixed adults from Mexico City"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-7035","authenticated-orcid":false,"given":"Jason M.","family":"Torres","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"},{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-3317","authenticated-orcid":false,"given":"Jaime","family":"Berumen","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-3768","authenticated-orcid":false,"given":"Diego","family":"Aguilar-Ramirez","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7655-5905","authenticated-orcid":false,"given":"Eirini","family":"Trichia","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-6203","authenticated-orcid":false,"given":"Francisco","family":"Barajas-Olmos","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunogen\u00f3mica y Enfermedades Metab\u00f3licas, Instituto Nacional de Medicina Gen\u00f3mica, Tlalpan, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-980X","authenticated-orcid":false,"given":"Humberto","family":"Garc\u00eda-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunogen\u00f3mica y Enfermedades Metab\u00f3licas, Instituto Nacional de Medicina Gen\u00f3mica, Tlalpan, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-1100","authenticated-orcid":false,"given":"Sam","family":"Morris","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-4053","authenticated-orcid":false,"given":"Michael","family":"Turner","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6168-8173","authenticated-orcid":false,"given":"Elizabeth","family":"Barrera","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-3321","authenticated-orcid":false,"given":"Consuelo D.","family":"Quinto-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Aging Research Center, Cinvestav Sede Sur, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-6303","authenticated-orcid":false,"given":"Lauren E.","family":"Petty","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-1157","authenticated-orcid":false,"given":"Lourdes","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud P\u00fablica, Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Tusi\u00e9-Luna","sequence":"additional","affiliation":[{"name":"Unidad de Biolog\u00eda Molecular y Medicina Gen\u00f3mica, Instituto de Investigaciones Biom\u00e9dicas UNAM\/Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Aguilar-Salinas","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d \/ Escuela de Medicina, Tecnol\u00f3gico de Monterrey, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Y.","family":"Chong","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-5931","authenticated-orcid":false,"given":"Paulina","family":"Baca","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivas","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-6886","authenticated-orcid":false,"given":"Fiona","family":"Bragg","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"},{"name":"Health Data Research UK Oxford, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-2220","authenticated-orcid":false,"given":"Louisa","family":"Gnatiuc Friedrichs","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hill","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-4307","authenticated-orcid":false,"given":"Lisa","family":"Holland","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-2233","authenticated-orcid":false,"given":"Alejandra","family":"Vergara-Lope","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wade","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gaziano","sequence":"additional","affiliation":[{"name":"Department of Aging, Brigham and Women\u2019s Hospital, Boston, MA 02215, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Collins","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6444","authenticated-orcid":false,"given":"Eleanor","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-4305","authenticated-orcid":false,"given":"Alan R.","family":"Shuldiner","sequence":"additional","affiliation":[{"name":"Regeneron Genetics Center, Tarrytown, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Below","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-0366","authenticated-orcid":false,"given":"Kari E.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Aging, Brigham and Women\u2019s Hospital, Boston, MA 02215, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-8292","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Moreno-Estrada","sequence":"additional","affiliation":[{"name":"Aging Research Center, Cinvestav Sede Sur, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-9180","authenticated-orcid":false,"given":"Lorena","family":"Orozco","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunogen\u00f3mica y Enfermedades Metab\u00f3licas, Instituto Nacional de Medicina Gen\u00f3mica, Tlalpan, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-3871","authenticated-orcid":false,"given":"Jes\u00fas","family":"Alegre-D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Kuri-Morales","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, Proyecto OriGen, Monterrey, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-9422","authenticated-orcid":false,"given":"Jonathan R.","family":"Emberson","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tapia-Conyer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026062706050488000_2026.06.23.26356360v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0637-y"},{"key":"2026062706050488000_2026.06.23.26356360v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01058-3"},{"key":"2026062706050488000_2026.06.23.26356360v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07019-6"},{"key":"2026062706050488000_2026.06.23.26356360v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0580-y"},{"key":"2026062706050488000_2026.06.23.26356360v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nature12828"},{"key":"2026062706050488000_2026.06.23.26356360v1.6","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0187"},{"key":"2026062706050488000_2026.06.23.26356360v1.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.6511"},{"key":"2026062706050488000_2026.06.23.26356360v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2018.07.006"},{"key":"2026062706050488000_2026.06.23.26356360v1.9","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1038\/s41467-021-26188-w","article-title":"The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas","volume":"12","year":"2021","journal-title":"Nat. Commun"},{"key":"2026062706050488000_2026.06.23.26356360v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06595-3"},{"key":"2026062706050488000_2026.06.23.26356360v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03205-y"},{"key":"2026062706050488000_2026.06.23.26356360v1.12","first-page":"1521","article-title":"Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations","volume":"30","year":"2021","journal-title":"Hum. Mol. Genet"},{"key":"2026062706050488000_2026.06.23.26356360v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/nature18642"},{"key":"2026062706050488000_2026.06.23.26356360v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0241-6"},{"key":"2026062706050488000_2026.06.23.26356360v1.15","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00864-4"},{"key":"2026062706050488000_2026.06.23.26356360v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"2026062706050488000_2026.06.23.26356360v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1231-2"},{"key":"2026062706050488000_2026.06.23.26356360v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2915"},{"key":"2026062706050488000_2026.06.23.26356360v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06560-0"},{"key":"2026062706050488000_2026.06.23.26356360v1.20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41591-025-04100-z","article-title":"Clinical genetic variation across Hispanic populations in the Mexican Biobank","volume":"32","year":"2026","journal-title":"Nat. Med"},{"key":"2026062706050488000_2026.06.23.26356360v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0084-1"},{"key":"2026062706050488000_2026.06.23.26356360v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03145-z"},{"key":"2026062706050488000_2026.06.23.26356360v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.024"},{"key":"2026062706050488000_2026.06.23.26356360v1.24","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf7044"},{"key":"2026062706050488000_2026.06.23.26356360v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.10.009"},{"key":"2026062706050488000_2026.06.23.26356360v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0101-4"},{"key":"2026062706050488000_2026.06.23.26356360v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21446-3"},{"key":"2026062706050488000_2026.06.23.26356360v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04951-w"},{"key":"2026062706050488000_2026.06.23.26356360v1.29","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1590\/S0036-36342010000700005","article-title":"Prevalence and distribution of type 2 diabetes mellitus in Mexican adult population: a probabilistic survey","volume":"52","year":"2010","journal-title":"Salud P\u00fablica M\u00e9xico"},{"key":"2026062706050488000_2026.06.23.26356360v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.67"},{"key":"2026062706050488000_2026.06.23.26356360v1.31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.110536"},{"key":"2026062706050488000_2026.06.23.26356360v1.32","doi-asserted-by":"publisher","DOI":"10.2337\/db20-1887-P"},{"key":"2026062706050488000_2026.06.23.26356360v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06693-2"},{"key":"2026062706050488000_2026.06.23.26356360v1.34","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/db23-0483","article-title":"RFX6 Maintains Gene Expression and Function of Adult Human Islet \u03b1-Cells","volume":"73","year":"2024","journal-title":"Diabetes"},{"key":"2026062706050488000_2026.06.23.26356360v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-02205473-8"},{"key":"2026062706050488000_2026.06.23.26356360v1.36","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s00125-024-06163-y","article-title":"RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function","volume":"67","year":"2024","journal-title":"Diabetologia"},{"key":"2026062706050488000_2026.06.23.26356360v1.37","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz276"},{"key":"2026062706050488000_2026.06.23.26356360v1.38","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41598-021-82728-w","article-title":"The MC4R p.Ile269Asn mutation confers a high risk for type 2 diabetes in the Mexican population via obesity dependent and independent effects","volume":"11","year":"2021","journal-title":"Sci. Rep"},{"key":"2026062706050488000_2026.06.23.26356360v1.39","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s42255-023-00970-0","article-title":"Genetic architecture and biology of youth-onset type 2 diabetes","volume":"6","year":"2024","journal-title":"Nat. Metab"},{"key":"2026062706050488000_2026.06.23.26356360v1.40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605368"},{"key":"2026062706050488000_2026.06.23.26356360v1.41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa520"},{"key":"2026062706050488000_2026.06.23.26356360v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1310-4"},{"key":"2026062706050488000_2026.06.23.26356360v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.11.005"},{"key":"2026062706050488000_2026.06.23.26356360v1.44","doi-asserted-by":"publisher","DOI":"10.1086\/519024"},{"key":"2026062706050488000_2026.06.23.26356360v1.45","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21614"},{"key":"2026062706050488000_2026.06.23.26356360v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02390-0"},{"key":"2026062706050488000_2026.06.23.26356360v1.47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003500"},{"key":"2026062706050488000_2026.06.23.26356360v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.024"},{"key":"2026062706050488000_2026.06.23.26356360v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3390"},{"key":"2026062706050488000_2026.06.23.26356360v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00783-5"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.23.26356360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:05:17Z","timestamp":1782565517000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.06.23.26356360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":50,"URL":"https:\/\/doi.org\/10.64898\/2026.06.23.26356360","relation":{},"subject":[],"published":{"date-parts":[[2026,6,25]]},"subtype":"preprint"}}