{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:28:03Z","timestamp":1786595283832,"version":"build-2736575974"},"posted":{"date-parts":[[2026,6,30]]},"group-title":"Neuroscience","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["F31NS129271-01"],"award-info":[{"award-number":["F31NS129271-01"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["1K99NS146256-01"],"award-info":[{"award-number":["1K99NS146256-01"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008483","name":"Nomis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008483","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00br6vq85","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"crossref","award":["2023-331214"],"award-info":[{"award-number":["2023-331214"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>Chronic sleep disruption and cognitive deficits are debilitating long-term consequences of traumatic brain injury (TBI), yet the endogenous mechanisms that drive network-level recovery remain poorly understood. Here, we demonstrate that during the chronic phase post-injury, network oscillations critical for memory, including slow oscillations, delta waves, and sleep spindles, undergo precise adaptive tuning that sustains sleep-dependent memory consolidation. This functional circuit resilience requires Semaphorin-3A (Sema3a); loss of Sema3a function prevents the protective reorganization of non-rapid eye movement (NREM) sleep architecture, impairs sleep-dependent memory consolidation, and exacerbates cortical lesion size. Together, these findings identify Sema3a as an innate protective mechanism that preserves sleep architecture and cognitive function following TBI.<\/jats:p>","DOI":"10.64898\/2026.06.24.734382","type":"posted-content","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:58:15Z","timestamp":1782845895000},"source":"Crossref","is-referenced-by-count":0,"title":["Semaphorin 3A promotes resilience of sleep and cognition to brain injury"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-0343","authenticated-orcid":false,"given":"D.","family":"Necula","sequence":"first","affiliation":[{"name":"Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA"},{"name":"Department of Neurology, and the Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-3002","authenticated-orcid":false,"given":"Y.","family":"Voskobiynyk","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA"},{"name":"Department of Neurology, and the Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-8381","authenticated-orcid":false,"given":"S.","family":"Poluri","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-8130","authenticated-orcid":false,"given":"J.T.","family":"Paz","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA"},{"name":"Department of Neurology, and the Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026081220501225000_2026.06.24.734382v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2012.08.008"},{"key":"2026081220501225000_2026.06.24.734382v2.2","doi-asserted-by":"publisher","DOI":"10.1186\/s41606-018-0020-4"},{"key":"2026081220501225000_2026.06.24.734382v2.3","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2021.672891"},{"key":"2026081220501225000_2026.06.24.734382v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.05.030"},{"key":"2026081220501225000_2026.06.24.734382v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.04.009"},{"key":"2026081220501225000_2026.06.24.734382v2.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437938100"},{"key":"2026081220501225000_2026.06.24.734382v2.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.040"},{"key":"2026081220501225000_2026.06.24.734382v2.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2024.02.002"},{"key":"2026081220501225000_2026.06.24.734382v2.9","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4119"},{"key":"2026081220501225000_2026.06.24.734382v2.10","doi-asserted-by":"crossref","unstructured":"Muehlroth, B.E. , Sander, M.C. , Fandakova, Y. , Grandy, T.H. , Rasch, B. , Shing, Y.L. , and Werkle-Bergner, M . 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