{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:14:11Z","timestamp":1783613651372,"version":"3.55.0"},"posted":{"date-parts":[[2026,7,7]]},"group-title":"Neurology","reference-count":57,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"national institute of health","award":["U19AG063911-02"],"award-info":[{"award-number":["U19AG063911-02"]}]},{"name":"national institute of health","award":["R01AG077557"],"award-info":[{"award-number":["R01AG077557"]}]},{"name":"national institute of health","award":["K23AG061253"],"award-info":[{"award-number":["K23AG061253"]}]},{"name":"national institute of health","award":["R01AG032289"],"award-info":[{"award-number":["R01AG032289"]}]},{"name":"national institute of health","award":["R01AG048234"],"award-info":[{"award-number":["R01AG048234"]}]},{"name":"UCSF ADRC","award":["P30AG062422"],"award-info":[{"award-number":["P30AG062422"]}]},{"name":"UCSF ADRC","award":["K23AG084883"],"award-info":[{"award-number":["K23AG084883"]}]},{"name":"UCSF ADRC","award":["R01AG072475"],"award-info":[{"award-number":["R01AG072475"]}]},{"name":"NIH\u2013NINDS","award":["UF1NS100608"],"award-info":[{"award-number":["UF1NS100608"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Motor disturbances are common in neurologic and neurodegenerative syndromes. A standard motor speed and dexterity measure is the finger tapping test (FTT). The FTT has traditionally been administered in clinic using a mechanical FTT, limiting accessibility and early motor change quantification. This study assessed the validity of a smartphone app-based FTT, which may expand access and enable more frequent testing.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cohort was diagnostically diverse, including participants with frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal syndrome, primary progressive aphasia, multiple sclerosis, and clinically unimpaired controls. Participants completed a 20-second ALLFTD Mobile App (mApp)-FTT with each hand. Tapping speed metrics were extracted. Participants completed the gold-standard mechanical FTT, a neurologist-administered finger tapping exam, the PSP Rating Scale (PSPRS) and the Unified Parkinson\u2019s Disease Rating Scale (UPDRS). Correlations assessed mApp-FTT and mechanical FTT relationships; regressions evaluated associations with neurologist-rated finger tapping impairment, PSPRS and UPDRS, adjusting for age and sex.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mApp-FTT showed moderate-to-strong correlations with the mechanical FTT (dominant: r=0.63, p&lt;0.001; non-dominant: r=0.55, p&lt;0.001). Taps per second were associated with PSPRS motor severity (dominant hand: std. \u03b2=-0.59, 95% CI [-0.91, -0.27], p&lt;0.001) and the UPDRS (dominant hand: std. \u03b2=-0.41, 95% CI [-0.82, 0.00], p=0.049). Flight time was modestly associated with neurologist-rated finger tapping impairment (dominant hand: std. \u03b2=0.15, 95% CI [0.00, 0.29], p=0.044).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings support mApp-FTT validity as a measure of motor function across neurodegenerative conditions. Validation in longitudinal and unsupervised remote settings is warranted to understand scalability and evaluate change over time.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.25.26356467","type":"posted-content","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:11:08Z","timestamp":1783469468000},"source":"Crossref","is-referenced-by-count":0,"title":["In-clinic validation of a smartphone-based finger tapping test for use in neurodegenerative and neurological populations"],"prefix":"10.64898","author":[{"given":"Morgan","family":"O\u2019Connor","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-3186","authenticated-orcid":false,"given":"Mark E.","family":"Sanderson-Cimino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for 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