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Whether this signaling system also shapes how reproduction declines with age has not been tested in any animal. Here we show that in\n                  <jats:italic>C. elegans<\/jats:italic>\n                  , the oxytocin\/vasopressin-like neuropeptide nematocin restrains reproductive output as animals reach mid-life. Nematocin and its two receptors are produced throughout adult life and peak as reproduction begins to wane. Animals lacking receptor signaling produce more offspring in mid-life, an improvement that reflects better egg quality and fertilization rather than improved embryo survival. This benefit is accompanied by changes in intestinal fat metabolism, the worm\u2019s equivalent of liver and adipose tissue: nematocin normally limits the activity of a fatty-acid desaturase that is otherwise induced by mating, and it shapes how much yolk reaches developing eggs. The two receptors act through separate routes, one tuning intestinal fat metabolism and the other controlling yolk delivery to the egg. Together, these findings reveal nematocin as a regulator of the intestinal metabolic environment across reproductive age, mirroring the recently described oxytocin-hepatocyte-adipocyte lipid axis in mammals and implicate this conserved signaling system in the coordination of maternal investment during reproductive aging.\n                <\/jats:p>","DOI":"10.64898\/2026.06.28.735098","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:05:25Z","timestamp":1783058725000},"source":"Crossref","is-referenced-by-count":0,"title":["Oxytocin-like signaling couples reproductive state to intestinal lipid metabolism in aging\n                  <i>C. elegans<\/i>"],"prefix":"10.64898","author":[{"given":"Katelyn M.","family":"Adam","sequence":"first","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"},{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Kuklinski","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Skinner","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Y.","family":"Lo","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Kochersberger","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-2139","authenticated-orcid":false,"given":"Jennifer L.","family":"Garrison","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging; Novato, CA, USA"},{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"},{"name":"Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA"},{"name":"Center for Healthy Aging in Women, Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026070607050571000_2026.06.28.735098v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab241"},{"key":"2026070607050571000_2026.06.28.735098v1.2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12676"},{"key":"2026070607050571000_2026.06.28.735098v1.3","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205190"},{"key":"2026070607050571000_2026.06.28.735098v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.11.005"},{"key":"2026070607050571000_2026.06.28.735098v1.5","doi-asserted-by":"publisher","DOI":"10.18632\/AGING.103237"},{"key":"2026070607050571000_2026.06.28.735098v1.6","doi-asserted-by":"crossref","unstructured":"Scharf, A. , Pohl, F. , Egan, B. 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