{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:59:23Z","timestamp":1785405563853,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,3]]},"group-title":"Neuroscience","reference-count":60,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R35GM161492"],"award-info":[{"award-number":["R35GM161492"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P20GM104318"],"award-info":[{"award-number":["P20GM104318"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"name":"MDI Biological Laboratory, Bar Harbor, US","award":["Salsbury Cove Research Fund"],"award-info":[{"award-number":["Salsbury Cove Research Fund"]}]},{"name":"Branco Weiss Fellowship"},{"award":["R310-2019-21"],"award-info":[{"award-number":["R310-2019-21"]}],"id":[{"id":"https:\/\/ror.org\/03hz8wd80","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R3472020-2393"],"award-info":[{"award-number":["R3472020-2393"]}],"id":[{"id":"https:\/\/ror.org\/03hz8wd80","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Novo Nordisk Laureate Grant"],"award-info":[{"award-number":["Novo Nordisk Laureate Grant"]}],"id":[{"id":"https:\/\/ror.org\/0435rc536","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ALTF 421-2018"],"award-info":[{"award-number":["ALTF 421-2018"]}],"id":[{"id":"https:\/\/ror.org\/04wfr2810","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ERC-2020-AdG-101021016"],"award-info":[{"award-number":["ERC-2020-AdG-101021016"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"publisher"}]},{"award":["V931-B"],"award-info":[{"award-number":["V931-B"]}],"id":[{"id":"https:\/\/ror.org\/013tf3c58","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P35614"],"award-info":[{"award-number":["P35614"]}],"id":[{"id":"https:\/\/ror.org\/013tf3c58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Tissue-clearing and light-sheet microscopy have transformed volumetric imaging of intact organs, yet limited mechanistic understanding of dehydration-based clearing continues to constrain rational protocol design and broader applicability. Here, we define the cardinal chemical and physical principles underlying dehydration-based tissue-clearing and establish a new pipeline for large-volume imaging. To maximize imaging performance, we developed the \u201cmesoSPIM-ultra\u201d, an upgraded mesoSPIM platform with a temperature-controlled sample chamber, a large field-of-view (FoV) camera and specialized optics to achieve long-working-distance, high-resolution imaging of cleared samples. We applied this approach to investigate the projectome of\n                  <jats:italic>Chx10<\/jats:italic>\n                  <jats:sup>+<\/jats:sup>\n                  neurons, a cell population with complex axonal morphologies along the entire mouse spinal-cord and brain, and implicated in ipsilateral orienting behaviors. By combining behavioral analysis with\n                  <jats:italic>post-hoc<\/jats:italic>\n                  single-neuron reconstructions, we revealed previously inaccessible branching architectures and long-range projections extending from the brainstem to the spinal cord. Together, our work establishes a mechanistic foundation for tissue-clearing and scalable imaging.\n                <\/jats:p>","DOI":"10.64898\/2026.06.29.734841","type":"posted-content","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:30:29Z","timestamp":1783135829000},"source":"Crossref","is-referenced-by-count":0,"title":["A uniform tissue-clearing framework and mesoSPIM-ultra enable cm-scale single-neuron tracing"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-390X","authenticated-orcid":false,"given":"Marko","family":"Pende","sequence":"first","affiliation":[{"name":"MDI Biological Laboratory, Bar Harbor, Maine, USA"},{"name":"The Jackson Laboratory, Bar Harbor, Maine, USA"},{"name":"Section of Bioelectronics, Center for Brain Research, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-9748","authenticated-orcid":false,"given":"Jared M.","family":"Cregg","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-541X","authenticated-orcid":false,"given":"Saiedeh","family":"Saghafi","sequence":"additional","affiliation":[{"name":"Meso Aspheric Optics & Light Sheet Fluorescence Microscopy, FKE, TU Wien, Vienna, 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G. , and Franklin, K.B.J. (2019). Paxinos and Franklin\u2019s The mouse brain in stereotaxic coordinates, 5th Edition (Academic Press, Elsevier)."},{"key":"2026070802250545000_2026.06.29.734841v1.58","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700213"},{"key":"2026070802250545000_2026.06.29.734841v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01846-0"},{"key":"2026070802250545000_2026.06.29.734841v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.013"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.29.734841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:25:23Z","timestamp":1783502723000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.29.734841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":60,"URL":"https:\/\/doi.org\/10.64898\/2026.06.29.734841","relation":{},"subject":[],"published":{"date-parts":[[2026,7,3]]},"subtype":"preprint"}}