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Chronic alcohol exposure before conception changes offspring phenotypes through epigenetic mechanisms that are still being elucidated. Preconception ethanol exposure studies have focused on paternal exposure, neglecting maternal and biparental exposure. To address this, we exposed adult male and female mice to five cycles of chronic intermittent ethanol vapor interleaved with two bottle choice ethanol drinking and mated them to produce male and female F1 offspring with paternal, maternal, or biparental preconception ethanol exposure or controls. Whole blood and medial prefrontal cortex from adult, ethanol-na\u00efve offspring underwent RNA-sequencing. We also analyzed previously unpublished RNA-sequencing data from male and female preimplantation embryos derived from preconception ethanol-exposed sires. Here, we report transcriptomic patterns of preconception ethanol exposure that depend on the exposed parent, offspring sex, and tissue which suggest metabolic and immune dysfunction in offspring.<\/jats:p>","DOI":"10.64898\/2026.06.29.735337","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:00:15Z","timestamp":1783119615000},"source":"Crossref","is-referenced-by-count":0,"title":["Preconception Chronic Intermittent Ethanol Exposure Impacts Offspring Transcriptomes with Sex and Tissue Specific Effects"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-7896","authenticated-orcid":false,"given":"Rachel C.","family":"Rice","sequence":"first","affiliation":[{"name":"Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa R.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela V.","family":"Gil","sequence":"additional","affiliation":[{"name":"Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy R.","family":"Frawley","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Y.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg E.","family":"Homanics","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Farris","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"5","key":"2026070702250432000_2026.06.29.735337v1.1","first-page":"1061","article-title":"The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies","volume":"45","year":"2014","journal-title":"Psychological Medicine"},{"key":"2026070702250432000_2026.06.29.735337v1.2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agw046"},{"key":"2026070702250432000_2026.06.29.735337v1.3","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12792"},{"key":"2026070702250432000_2026.06.29.735337v1.4","doi-asserted-by":"crossref","unstructured":"Rice RC , Gil DV , Baratta AM , et al. 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