{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:48:25Z","timestamp":1790063305285,"version":"4.0.1"},"posted":{"date-parts":[[2026,7,3]]},"group-title":"Physiology","reference-count":91,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R01HL164821"],"award-info":[{"award-number":["R01HL164821"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F31HL179970"],"award-info":[{"award-number":["F31HL179970"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Research Grant 004792G222"],"award-info":[{"award-number":["Research Grant 004792G222"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Research Grant 009144G225"],"award-info":[{"award-number":["Research Grant 009144G225"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"https:\/\/ror.org\/05ttxxx91","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Tissue hypoperfusion is common in clinical settings, but how tissues respond to hypoperfusion on a microphysiological scale is not clear. We used real-time confocal microscopy of live, perfused lungs to gain insights into the effects of hypoperfusion on the microcirculation and microphysiology of lung alveoli, where gas exchange occurs. We focused on effects of hypoperfusion on alveolar liquid secretion, since alveolar liquid secretion is important for alveolar homeostatic functions. Our findings show lung hypoperfusion stimulated a reversal of alveolar liquid transport, from homeostatic liquid secretion to absorption. Specifically, lung perfusion at or near physiological perfusion pressure led to alveolar liquid secretion that depended on the alveolar epithelial cystic fibrosis transmembrane conductance regulator (CFTR), Na\n                  <jats:sup>+<\/jats:sup>\n                  -K\n                  <jats:sup>+<\/jats:sup>\n                  -Cl\n                  <jats:sup>-<\/jats:sup>\n                  cotransporters, and the Na\n                  <jats:sup>+<\/jats:sup>\n                  \/K\n                  <jats:sup>+<\/jats:sup>\n                  -ATPase. Within minutes of halting lung perfusion or majorly reducing it, alveoli stopped secreting liquid and instead absorbed it via the epithelial Na\n                  <jats:sup>+<\/jats:sup>\n                  channel, CFTR, and K\n                  <jats:sup>+<\/jats:sup>\n                  -Cl\n                  <jats:sup>-<\/jats:sup>\n                  cotransporters. We provide evidence that hypoperfusion caused alveolar microvessel lumens to shrink and airspaces to expand, leading to epithelial stretch that stimulated liquid absorption. These findings show lung hypoperfusion initiates mechanical signals that stimulate the alveolar epithelium to absorb liquid, and they may inform the pathogenesis of lung diseases characterized by acute microvascular hypoperfusion.\n                <\/jats:p>","DOI":"10.64898\/2026.06.29.735362","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:20:17Z","timestamp":1783084817000},"source":"Crossref","is-referenced-by-count":1,"title":["Lung hypoperfusion stimulates liquid absorption in alveoli"],"prefix":"10.64898","author":[{"given":"Jimmy","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deebly","family":"Chavez","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayahi","family":"Suthakaran","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaya","family":"Sussman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-6568","authenticated-orcid":false,"given":"Sarah K. L.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente J.","family":"Britto","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaymin J.","family":"Kathiriya","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Stem Cell Biology and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hooman D.","family":"Poor","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Mount Sinai Respiratory Institute, Mount Sinai Health System, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-0060","authenticated-orcid":false,"given":"Jaime L.","family":"Hook","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Stem Cell Biology and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jjcc.2024.02.001","article-title":"Impact of postoperative hyperlactatemia in orthotopic heart transplantation","volume":"84","year":"2024","journal-title":"J Cardiol"},{"key":"2026070709100566000_2026.06.29.735362v1.2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003275"},{"key":"2026070709100566000_2026.06.29.735362v1.3","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9365-6"},{"key":"2026070709100566000_2026.06.29.735362v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.07.006"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/j.jvca.2020.04.045","article-title":"Severe impairment of microcirculatory perfused vessel density is associated with postoperative lactate and acute organ injury after cardiac surgery","volume":"35","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13054-022-04134-6","article-title":"Decreased renal cortical perfusion, independent of changes in renal blood flow and sublingual microcirculatory impairment, is associated with the severity of acute kidney injury in patients with septic shock","volume":"26","year":"2022","journal-title":"Crit Care"},{"key":"2026070709100566000_2026.06.29.735362v1.7","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04474-x"},{"key":"2026070709100566000_2026.06.29.735362v1.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000093540.78705.71"},{"issue":"5","key":"2026070709100566000_2026.06.29.735362v1.9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00000441-197411000-00001","article-title":"Pulmonary circulatory changes in pathogenesis of shock lung","volume":"268","year":"1974","journal-title":"Am J Med Sci"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.10","first-page":"10","article-title":"Hemorrhagic shock in dogs without major pulmonary changes","volume":"7","year":"1975","journal-title":"Eur Surg Res"},{"key":"2026070709100566000_2026.06.29.735362v1.11","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197506000-00020"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1152\/jappl.1990.69.2.597","article-title":"Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance","volume":"69","year":"1990","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.13","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1152\/jappl.1991.71.4.1554","article-title":"Lung ischemia-reperfusion injury in awake sheep: protection with verapamil","volume":"71","year":"1991","journal-title":"J Appl Physiol (1985)"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1152\/jappl.1992.72.2.621","article-title":"Inflammation and oxygen free radical formation during pulmonary ischemia-reperfusion injury","volume":"72","year":"1992","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.15","first-page":"512","article-title":"Effect of acute hemorrhagic shock on pulmonary microvascular fluid filtration and protein permeability in sheep","volume":"77","year":"1975","journal-title":"Surgery"},{"issue":"3","key":"2026070709100566000_2026.06.29.735362v1.16","first-page":"498","article-title":"Pulmonary microvascular response to hemorrhagic shock, resuscitation, and recovery","volume":"46","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"6","key":"2026070709100566000_2026.06.29.735362v1.17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00004424-198111000-00003","article-title":"A computed tomographic study of the dog lung during hemorrhagic shock and after resuscitation","volume":"16","year":"1981","journal-title":"Invest Radiol"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1152\/jappl.1969.26.1.65","article-title":"Measurements of capillary dimensions and blood volume in rapidly frozen lungs","volume":"26","year":"1969","journal-title":"J Appl Physiol"},{"key":"2026070709100566000_2026.06.29.735362v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/s44341-025-00026-2"},{"key":"2026070709100566000_2026.06.29.735362v1.20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199602)244:2<182::AID-AR6>3.0.CO;2-3"},{"key":"2026070709100566000_2026.06.29.735362v1.21","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00008.2007"},{"key":"2026070709100566000_2026.06.29.735362v1.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216382110"},{"issue":"12","key":"2026070709100566000_2026.06.29.735362v1.23","doi-asserted-by":"crossref","first-page":"e1240","DOI":"10.1097\/CCM.0000000000002720","article-title":"Cystic Fibrosis Transmembrane Conductance Regulator potentiation as a therapeutic strategy for pulmonary edema: a proof-of-concept study in pigs","volume":"45","year":"2017","journal-title":"Crit Care Med"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.24","doi-asserted-by":"crossref","first-page":"L229","DOI":"10.1152\/ajplung.00289.2024","article-title":"CFTR as a therapeutic target for severe lung infection","volume":"328","year":"2025","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026070709100566000_2026.06.29.735362v1.25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95823"},{"key":"2026070709100566000_2026.06.29.735362v1.26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163402"},{"key":"2026070709100566000_2026.06.29.735362v1.27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1154OC"},{"key":"2026070709100566000_2026.06.29.735362v1.28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002194"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.29","first-page":"20458940211041512","article-title":"Mouse model of experimental pulmonary hypertension: lung angiogram and right heart catheterization","volume":"11","year":"2021","journal-title":"Pulm Circ"},{"key":"2026070709100566000_2026.06.29.735362v1.30","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0347OC"},{"key":"2026070709100566000_2026.06.29.735362v1.31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.162933"},{"key":"2026070709100566000_2026.06.29.735362v1.32","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.108.3.133"},{"key":"2026070709100566000_2026.06.29.735362v1.33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2991"},{"key":"2026070709100566000_2026.06.29.735362v1.34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8258"},{"key":"2026070709100566000_2026.06.29.735362v1.35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00562.2002"},{"issue":"3","key":"2026070709100566000_2026.06.29.735362v1.36","first-page":"233","article-title":"Dehydration parameters and standards for laboratory mice","volume":"52","year":"2013","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"2026070709100566000_2026.06.29.735362v1.37","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0686-3"},{"key":"2026070709100566000_2026.06.29.735362v1.38","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00256.2002"},{"key":"2026070709100566000_2026.06.29.735362v1.39","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-002-1049-x"},{"key":"2026070709100566000_2026.06.29.735362v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.05.002"},{"key":"2026070709100566000_2026.06.29.735362v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.05.126"},{"key":"2026070709100566000_2026.06.29.735362v1.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109083119"},{"key":"2026070709100566000_2026.06.29.735362v1.43","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00030.2001"},{"key":"2026070709100566000_2026.06.29.735362v1.44","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.1.211"},{"key":"2026070709100566000_2026.06.29.735362v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.07.009"},{"key":"2026070709100566000_2026.06.29.735362v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.05.008"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.47","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/jappl.1999.87.2.715","article-title":"Mechanical stretching of alveolar epithelial cells increases Na(+)-K(+)-ATPase activity","volume":"87","year":"1999","journal-title":"J Appl Physiol (1985)"},{"key":"2026070709100566000_2026.06.29.735362v1.48","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00252.2013"},{"key":"2026070709100566000_2026.06.29.735362v1.49","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.1.L5"},{"key":"2026070709100566000_2026.06.29.735362v1.50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00160.2007"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1748-1716.1975.tb05858.x","article-title":"Transcapillary fluid movements in sympathectomized intestine and skin during hemorrhagic hypotension","volume":"94","year":"1975","journal-title":"Acta Physiol Scand"},{"key":"2026070709100566000_2026.06.29.735362v1.52","doi-asserted-by":"crossref","unstructured":"Lucas ML , and Morrison JD . An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat. Physiol Rep. 2015;3(5).","DOI":"10.14814\/phy2.12407"},{"key":"2026070709100566000_2026.06.29.735362v1.53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1967.tb03707.x"},{"key":"2026070709100566000_2026.06.29.735362v1.54","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.8.913"},{"key":"2026070709100566000_2026.06.29.735362v1.55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00146"},{"key":"2026070709100566000_2026.06.29.735362v1.56","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00206.2011"},{"key":"2026070709100566000_2026.06.29.735362v1.57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.37.3.781"},{"issue":"6","key":"2026070709100566000_2026.06.29.735362v1.58","first-page":"1315","article-title":"Differential permeability of endothelial and epithelial barriers to albumin flux","volume":"47","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.59","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1152\/jappl.1991.70.4.1518","article-title":"Flow through zone 1 lungs utilizes alveolar corner vessels","volume":"70","year":"1991","journal-title":"J Appl Physiol (1985)"},{"key":"2026070709100566000_2026.06.29.735362v1.60","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90466.2008"},{"key":"2026070709100566000_2026.06.29.735362v1.61","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00130.2000"},{"key":"2026070709100566000_2026.06.29.735362v1.62","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000059414.10360.F2"},{"key":"2026070709100566000_2026.06.29.735362v1.63","doi-asserted-by":"crossref","unstructured":"Suthakaran S , et al. CFTR function in alveolar type 1 cells drives lung liquid secretion and host defense. bioRxiv. 2025:2025.03.25.645303.","DOI":"10.1101\/2025.03.25.645303"},{"key":"2026070709100566000_2026.06.29.735362v1.64","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1964.19.4.713"},{"key":"2026070709100566000_2026.06.29.735362v1.65","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2021"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.66","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1152\/jappl.1991.70.4.1854","article-title":"Permeability characteristics of isolated perfused rat lungs","volume":"70","year":"1991","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.67","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1152\/jappl.1998.85.4.1572","article-title":"Time course of active and passive liquid and solute movement in the isolated perfused rat lung model","volume":"85","year":"1998","journal-title":"J Appl Physiol (1985)"},{"key":"2026070709100566000_2026.06.29.735362v1.68","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2391-y"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.69","first-page":"1","article-title":"Pulmonary sumps, dust accumulations, alveolar fluid and lymph vessels","volume":"23","year":"1955","journal-title":"Acta Anat (Basel"},{"issue":"3","key":"2026070709100566000_2026.06.29.735362v1.70","first-page":"449","article-title":"A hypothesis for pulmonary clearance and its implications","volume":"98","year":"1968","journal-title":"Am Rev Respir Dis"},{"issue":"9","key":"2026070709100566000_2026.06.29.735362v1.71","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1096\/fj.202000613RRR","article-title":"Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells","volume":"34","year":"2020","journal-title":"FASEB J"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.72","first-page":"905","article-title":"Surfactant release in excised rat lung is stimulated by air inflation","volume":"51","year":"1981","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"2026070709100566000_2026.06.29.735362v1.73","doi-asserted-by":"publisher","DOI":"10.1126\/science.2173861"},{"key":"2026070709100566000_2026.06.29.735362v1.74","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00332.2003"},{"key":"2026070709100566000_2026.06.29.735362v1.75","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-011-0365-4"},{"issue":"13","key":"2026070709100566000_2026.06.29.735362v1.76","doi-asserted-by":"crossref","first-page":"e33499","DOI":"10.1016\/j.heliyon.2024.e33499","article-title":"Overstretching alveolar epithelial type II cells decreases surfactant secretion via actin polymerization and intracellular trafficking alteration","volume":"10","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"2026070709100566000_2026.06.29.735362v1.77","doi-asserted-by":"crossref","first-page":"14803","DOI":"10.1038\/s41598-021-93987-y","article-title":"Cyclic stretching-induced epithelial cell reorientation is driven by microtubule-modulated transverse extension during the relaxation phase","volume":"11","year":"2021","journal-title":"Sci Rep"},{"key":"2026070709100566000_2026.06.29.735362v1.78","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0005OC"},{"key":"2026070709100566000_2026.06.29.735362v1.79","doi-asserted-by":"publisher","DOI":"10.1378\/chest.74.4.426"},{"key":"2026070709100566000_2026.06.29.735362v1.80","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0286OC"},{"key":"2026070709100566000_2026.06.29.735362v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(68)90049-2"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.82","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1113\/jphysiol.1979.sp012790","article-title":"The importance of flow pulsatility for the rate of transvascular fluid filtration in lungs","volume":"290","year":"1979","journal-title":"J Physiol"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.83","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/01.RES.42.4.550","article-title":"Effect of positive pressure breathing on lung lymph flow and water content in sheep","volume":"42","year":"1978","journal-title":"Circ Res"},{"key":"2026070709100566000_2026.06.29.735362v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.11.015"},{"key":"2026070709100566000_2026.06.29.735362v1.85","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.9.1163"},{"key":"2026070709100566000_2026.06.29.735362v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.03.027"},{"issue":"4","key":"2026070709100566000_2026.06.29.735362v1.87","first-page":"375","article-title":"Clinical chemistry reference intervals for C57BL\/6J, C57BL\/6N, and C3HeB\/FeJ mice (Mus musculus)","volume":"55","year":". 2016","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"2026070709100566000_2026.06.29.735362v1.88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117988108"},{"key":"2026070709100566000_2026.06.29.735362v1.89","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0125OC"},{"key":"2026070709100566000_2026.06.29.735362v1.90","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20335"},{"issue":"2","key":"2026070709100566000_2026.06.29.735362v1.91","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1152\/japplphysiol.00073.2025","article-title":"A rapid increase in left atrial pressure reduces pulmonary arterial compliance in rats: insights from pulmonary arterial impedance analysis","volume":"139","year":"2025","journal-title":"J Appl Physiol (1985)"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.29.735362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:10:34Z","timestamp":1783440634000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.06.29.735362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":91,"URL":"https:\/\/doi.org\/10.64898\/2026.06.29.735362","relation":{},"subject":[],"published":{"date-parts":[[2026,7,3]]},"subtype":"preprint"}}