{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:59:10Z","timestamp":1785416350641,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,2]]},"group-title":"Epidemiology","reference-count":30,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/043jzw605","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/02qa92s63","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare trends in incidence and mortality rates for cancers with rising incidence in younger adults in England, and to assess whether increasing incidence is observed for early-stage, late-stage or both types of disease.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>We used cancer incidence and mortality data from English National Disease Registration Service (2001-2023). Analyses focused on 12 cancers with increasing incidence (on average) in younger adults (20-49 years) and more than 500 cases diagnosed in 2023. Trends were quantified by estimating the average annual percentage changes (AAPCs) and 95% confidence intervals (CI) using Joinpoint regression and by calculating the excess number of cancer cases in 2023 compared to 2001. Age-standardised rates (ASRs) of early (stage 1-2) and late-stage (stage 3-4) disease were compared between 2013 (the earliest year available) to 2023.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 31,385 cancers diagnosed in younger adults in 2023 compared to 244,384 in older adults. The most common cancers diagnosed in younger adults were female breast (n=8,504), colorectal (n=2,977) and melanoma (n=2,767). Of the 12 cancers that were increasing in younger adults between 2001 and 2023, only two also had increasing mortality rates: endometrial (AAPC[95%CI]= incidence 2.9%[2.4-3.4%] and mortality 4.0%[2.1-6.0%]) and colorectal cancer (AAPC[95%CI]= incidence 3.2%[2.8-3.6%] and mortality 1.9%[1.1-2.7%]). For thyroid cancer mortality rates were stable and for the other cancers (female breast, testicular, ovarian, kidney, brain, prostate, Hodgkin lymphoma and leukaemia) although incidence rates were increasing, mortality rates were decreasing, on average. Of the ten cancers with available stage data six showed increases in incidence rates for both early and late-stage disease between 2013 and 2023. Four cancers showed increases only in late-stage disease (female breast, ovarian, melanoma and Hodgkin lymphoma), while thyroid cancer showed an increase only in early-stage disease.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These population-wide analyses of national data from England, combining cancer incidence, mortality and stage-stratified incidence trends, highlight several public health and research priorities. These include identifying the causes of increasing colorectal cancer incidence in younger adults, given the marked increases in mortality and late-stage disease, and of increasing breast cancer incidence, which affects the largest number of younger adults and is increasing only for late-stage disease.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>KEY MESSAGES<\/jats:title>\n                  <jats:sec>\n                    <jats:title>What is already known on this topic<\/jats:title>\n                    <jats:p>Incidence rates for several cancers are rising among younger adults in England. Data from the USA has shown increases in late-stage disease for several cancers increasing in younger adults, but parallel increases in mortality have been observed only for colorectal and endometrial cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>What this study adds<\/jats:title>\n                    <jats:p>In younger adults, incidence rates of late-stage disease increased from 2013-2023 for all cancers with available stage data except thyroid cancer. However, only endometrial and colorectal cancer showed parallel increases in mortality rates from 2001-2023. Despite these increases, the absolute numbers of diagnoses and deaths remained relatively small compared to those in older adults (age 50+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>How this study might affect research, practice or policy<\/jats:title>\n                    <jats:p>This study identifies current priorities for research and cancer prevention, interception and early detection in younger adults, underscoring the need for in-depth investigation of cancers with concurrent increases in incidence, mortality, and both for both early- and late-stage disease.<\/jats:p>\n                  <\/jats:sec>\n                <\/jats:sec>","DOI":"10.64898\/2026.06.30.26356042","type":"posted-content","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:16:39Z","timestamp":1783008999000},"source":"Crossref","is-referenced-by-count":0,"title":["Cancer trends in England in younger adults from 2001-2023: comparing incidence, mortality and stage at diagnosis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-8387","authenticated-orcid":false,"given":"Amy","family":"Berrington de Gonzalez","sequence":"first","affiliation":[{"name":"Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK"},{"name":"Cancer Epidemiology and Prevention Research Unit (CEPRU), The Institute of Cancer Research, and Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esme","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK"},{"name":"Cancer Epidemiology and Prevention Research Unit (CEPRU), The Institute of Cancer Research, and Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoey","family":"Richards","sequence":"additional","affiliation":[{"name":"Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK"},{"name":"Cancer Epidemiology and Prevention Research Unit (CEPRU), The Institute of Cancer Research, and Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Frost","sequence":"additional","affiliation":[{"name":"Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S","family":"Shiel","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aislinn","family":"Macklin-Doherty","sequence":"additional","affiliation":[{"name":"Division of Genetics & Epidemiology, The Institute of Cancer Research, London, 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