{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:19:13Z","timestamp":1783181953469,"version":"3.54.6"},"posted":{"date-parts":[[2026,7,2]]},"group-title":"Cardiovascular Medicine","reference-count":6,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,2]]},"abstract":"Structured Abstract<\/jats:title>\n \n Background<\/jats:title>\n Iatrogenic atrial septal defect (iASD) is a known consequence of transseptal catheterization. Left atrial intracardiac echocardiography (LA ICE) requires additional septal instrumentation, yet data on persistent iASD after pulsed field ablation (PFA) with an LA ICE workflow remain limited. We evaluated the incidence, predictors, and one-year clinical significance of persistent iASD in this setting.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Consecutive patients undergoing PFA for atrial fibrillation with LA ICE were prospectively evaluated with transthoracic echocardiography before ablation and at one year, including systematic agitated saline contrast. Persistent iASD was defined as residual interatrial shunting on color Doppler at follow-up, classified as small (<3 mm), moderate (3\u20135 mm), or large (>5 mm). Groups were compared by t-test and chi-square test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 850 patients, persistent iASD was identified in 153 (18.0%) at one year; 97 (63.4%) were small and 56 (36.6%) moderate, with no large defects. All shunts were left-to-right. No stroke or transient ischemic attack, paradoxical embolism, hypoxemia, right-heart enlargement, or septal closure occurred. Persistent iASD was associated with female sex (64.7% vs 48.1%), longer septal dwell time (52\u00b112 vs 31\u00b111 min), higher left atrial pressure (28\u00b14 vs 12\u00b13 mmHg), lower LVEF (32\u00b111% vs 54\u00b114%), and larger-caliber sheaths (\u226517 Fr; 80.4% vs 48.2%; all p<0.001).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Persistent iASD following PFA with LA ICE occurs in approximately one in five patients but is predominantly small, exclusively left-to-right, and clinically benign at one year. Persistence is associated with mechanical and hemodynamic factors, particularly sheath caliber, rather than the ablation energy source.<\/jats:p>\n <\/jats:sec>\n \n Nonstandard Abbreviations and Acronyms<\/jats:title>\n AF, atrial fibrillation; iASD, iatrogenic atrial septal defect; ICE, intracardiac echocardiography; LA, left atrial; LVEF, left ventricular ejection fraction; OD, outer diameter; PFA, pulsed field ablation; RF, radiofrequency; TIA, transient ischemic attack.<\/jats:p>\n <\/jats:sec>\n \n Data Availability<\/jats:title>\n The data that support the findings of this study are available from the corresponding author upon reasonable request.<\/jats:p>\n <\/jats:sec>\n \n Central Illustration<\/jats:title>\n \n \n Central Illustration.<\/jats:label>\n \n Persistent iASD occurred in 18.0% of 850 patients undergoing PFA with LA ICE but was predominantly small, exclusively left-to-right, and clinically benign at one year.<\/jats:title>\n Persistence tracked with mechanical and hemodynamic factors, most notably transseptal sheath caliber, rather than the ablation energy source.<\/jats:p>\n <\/jats:caption>\n \n <\/jats:fig>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.64898\/2026.06.30.26356981","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:45:10Z","timestamp":1783050310000},"source":"Crossref","is-referenced-by-count":0,"title":["Persistent Iatrogenic Atrial Septal Defect Following Pulsed Field Ablation Guided by Left Atrial Intracardiac Echocardiography: Incidence, Predictors, and Clinical Outcomes"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6356-9809","authenticated-orcid":false,"given":"Mohamed","family":"Mraiyan","sequence":"first","affiliation":[{"name":"St. Bernards Medical Center, Jonesboro, AR, USA"},{"name":"Arrhythmia Research Group, Jonesboro, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Nair","sequence":"additional","affiliation":[{"name":"Arrhythmia Research Group, Jonesboro, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-7151","authenticated-orcid":false,"given":"Brandon","family":"Doty","sequence":"additional","affiliation":[{"name":"Arrhythmia Research Group, Jonesboro, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-947X","authenticated-orcid":false,"given":"Devi G.","family":"Nair","sequence":"additional","affiliation":[{"name":"St. Bernards Medical Center, Jonesboro, AR, USA"},{"name":"Arrhythmia Research Group, Jonesboro, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026070408500477000_2026.06.30.26356981v1.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"2026070408500477000_2026.06.30.26356981v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.04.034"},{"key":"2026070408500477000_2026.06.30.26356981v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur138"},{"key":"2026070408500477000_2026.06.30.26356981v1.4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2016.02.068","article-title":"Iatrogenic atrial septal defect following transseptal cardiac interventions","volume":"209","year":"2016","journal-title":"Int J Cardiol"},{"issue":"1","key":"2026070408500477000_2026.06.30.26356981v1.5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10840-019-00598-9","article-title":"Prospective evaluation of iatrogenic atrial septal defect after cryoballoon or radiofrequency catheter ablation of atrial fibrillation, the \u201cEVITA\u201d study","volume":"56","year":"2019","journal-title":"J Interv Card Electrophysiol"},{"issue":"6","key":"2026070408500477000_2026.06.30.26356981v1.6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jjcc.2024.06.007","article-title":"Incidence and predictors of persistent iatrogenic atrial septal defect following catheter ablation","volume":"84","year":"2024","journal-title":"J Cardiol"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.06.30.26356981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:50:16Z","timestamp":1783180216000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.06.30.26356981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":6,"URL":"https:\/\/doi.org\/10.64898\/2026.06.30.26356981","relation":{},"subject":[],"published":{"date-parts":[[2026,7,2]]},"subtype":"preprint"}}