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Non-human primate studies of F5 have shown that it encodes a wide range of hand positions and object properties. Human studies in F5\u2019s human homologue, the inferior frontal gyrus (IFG), have leveraged this area\u2019s ability to encode grasp-object pairs for the purposes of Brain Machine Interface (BMI) control. However, whether modulation is driven by grasp, object, or the interaction between grasp and object is unclear. In the present study, intracortical IFG signals were recorded from human participants with tetraplegia during a motor visualization task where grasp and object were varied. Grasp was found to be the predominant factor driving modulation of IFG signals. Object was found to only be weakly represented in neural data. However, object contribution peaked earlier than grasp contribution, indicating early integration of object information. Grasp-object interactions were also found to have a significant impact. Cortical separation between object conditions varied based on the grasp used. In addition, subspace analysis showed that the underlying neural population structure associated with each grasp type was significantly different from one another. Despite the impact of grasp-object interactions, the present study demonstrates that grasp is the primary driver of inferior frontal gyrus neural modulation.<\/jats:p>","DOI":"10.64898\/2026.06.30.735663","type":"posted-content","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:00:17Z","timestamp":1782925217000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Relative Impact of Grasp and Object on Inferior Frontal Gyrus Activity during a Grasping Task"],"prefix":"10.64898","author":[{"given":"Emily C.","family":"Conlan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Cleveland Functional Electrical Stimulation Center of Excellence, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crispin","family":"Foli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Cleveland Functional Electrical Stimulation Center of Excellence, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Memberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Cleveland Functional Electrical Stimulation Center of Excellence, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Z.","family":"Herring","sequence":"additional","affiliation":[{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Neurosurgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5436-7594","authenticated-orcid":false,"given":"Jennifer A.","family":"Sweet","sequence":"additional","affiliation":[{"name":"Cleveland Functional Electrical Stimulation Center of Excellence, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA"},{"name":"School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"Department of Neurosurgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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