{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:17:15Z","timestamp":1785428235249,"version":"3.56.0"},"posted":{"date-parts":[[2026,7,7]]},"group-title":"Immunology","reference-count":101,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["R01HL126066"],"award-info":[{"award-number":["R01HL126066"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI189410"],"award-info":[{"award-number":["R01AI189410"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"EU grant","award":["101136926 MULTIR"],"award-info":[{"award-number":["101136926 MULTIR"]}]},{"name":"Research Ireland grant","award":["22\/PATH-S\/10875"],"award-info":[{"award-number":["22\/PATH-S\/10875"]}]},{"name":"Leducq Foundation for Cardiovascular Research grant ARTIST"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Type I interferons (IFN-I) and IFN\u03b3 exert divergent effects during tuberculosis, but the mechanisms that determine whether macrophage activation promotes host defense or inflammatory pathology remain incompletely understood. Here, we dissect the interplay between IFN-I and IFN\u03b3 in macrophage activation using genetically susceptible B6.Sst1S macrophages. We show that, during tumor necrosis factor (TNF) stimulation, susceptible macrophages enter a persistent pathological activation state (pPAS) characterized by sustained lipid peroxidation and super-induction of IFN-I responses. This pathological state is maintained by autocrine IFN-I signaling. In contrast, IFN\u03b3 priming prevents pPAS development by enhancing macrophage resilience to oxidative stress, in part through regulation of iron metabolism and induction of ferritin expression. Computational\n                  <jats:bold>c<\/jats:bold>\n                  ell\n                  <jats:bold>s<\/jats:bold>\n                  tate\n                  <jats:bold>t<\/jats:bold>\n                  ransition\n                  <jats:bold>a<\/jats:bold>\n                  ssessment and\n                  <jats:bold>r<\/jats:bold>\n                  egulation (cSTAR) analysis identified pathways and small molecules predicted to promote the transition of susceptible macrophages toward an IFN\u03b3-induced, Mtb-resistant state. Consistent with these predictions, the CDK4\/6 inhibitor trilaciclib reduced lipid peroxidation by regulating iron metabolism, whereas retinoic acid signaling enhanced GPX4 expression and lipid biosynthesis programs. Combined CDK4\/6 inhibition and retinoic acid receptor activation efficiently prevented the pathological activation state. Together, these findings delineate a mechanism of IFN-I\/IFN\u03b3 crosstalk during macrophage activation and identify pharmacologic strategies to prevent IFN-I-dominant, lipid peroxidation-driven macrophage pathology.\n                <\/jats:p>","DOI":"10.64898\/2026.07.01.735930","type":"posted-content","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:25:12Z","timestamp":1783466712000},"source":"Crossref","is-referenced-by-count":0,"title":["IFN\n                  <i>\u03b3<\/i>\n                  and IFN\n                  <i>\u03b3<\/i>\n                  mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-3826","authenticated-orcid":false,"given":"Prasanna Babu","family":"Araveti","sequence":"first","affiliation":[{"name":"The National Emerging Infectious Diseases Laboratories, Boston University, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-1661","authenticated-orcid":false,"given":"Shivraj M.","family":"Yabaji","sequence":"additional","affiliation":[{"name":"The National Emerging Infectious Diseases Laboratories, Boston University, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3436-7380","authenticated-orcid":false,"given":"Muhammad Zainul","family":"Arifin","sequence":"additional","affiliation":[{"name":"Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-9315","authenticated-orcid":false,"given":"Suruchi","family":"Lata","sequence":"additional","affiliation":[{"name":"The National Emerging Infectious Diseases Laboratories, Boston University, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-8861","authenticated-orcid":false,"given":"Yuriy O.","family":"Alekseyev","sequence":"additional","affiliation":[{"name":"The Department of Pathology and Laboratory Medicine, Boston University Chobanian Avedisian School of Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-0285","authenticated-orcid":false,"given":"Alexander A.","family":"Gimelbrant","sequence":"additional","affiliation":[{"name":"Altius Institute for Biomedical Sciences, Seattle, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8734-4118","authenticated-orcid":false,"given":"William R.","family":"Bishai","sequence":"additional","affiliation":[{"name":"Center for TB Research, Johns Hopkins School of Medicine, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-1142","authenticated-orcid":false,"given":"Vadim","family":"Zhernovkov","sequence":"additional","affiliation":[{"name":"Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-4987","authenticated-orcid":false,"given":"Oleksii S.","family":"Rukhlenko","sequence":"additional","affiliation":[{"name":"Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9483-4975","authenticated-orcid":false,"given":"Boris N.","family":"Kholodenko","sequence":"additional","affiliation":[{"name":"Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland"},{"name":"Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland"},{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-9246","authenticated-orcid":false,"given":"Igor","family":"Kramnik","sequence":"additional","affiliation":[{"name":"The National Emerging Infectious Diseases Laboratories, Boston University, Boston, United States"},{"name":"Pulmonary Center, The Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, United States"},{"name":"Department of Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026071003151055000_2026.07.01.735930v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01523-7"},{"key":"2026071003151055000_2026.07.01.735930v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.05.026"},{"key":"2026071003151055000_2026.07.01.735930v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"2026071003151055000_2026.07.01.735930v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01683-0"},{"key":"2026071003151055000_2026.07.01.735930v1.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707-1475OC"},{"key":"2026071003151055000_2026.07.01.735930v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"2026071003151055000_2026.07.01.735930v1.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130319"},{"key":"2026071003151055000_2026.07.01.735930v1.8","doi-asserted-by":"publisher","DOI":"10.18129\/B9.bioc.PCAtools"},{"key":"2026071003151055000_2026.07.01.735930v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abq5389"},{"key":"2026071003151055000_2026.07.01.735930v1.10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20250466"},{"key":"2026071003151055000_2026.07.01.735930v1.11","doi-asserted-by":"publisher","DOI":"10.64898\/2025.12.05.692491"},{"key":"2026071003151055000_2026.07.01.735930v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102845"},{"key":"2026071003151055000_2026.07.01.735930v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.11.008"},{"key":"2026071003151055000_2026.07.01.735930v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600302"},{"key":"2026071003151055000_2026.07.01.735930v1.15","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis499"},{"key":"2026071003151055000_2026.07.01.735930v1.16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-125148"},{"key":"2026071003151055000_2026.07.01.735930v1.17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2243"},{"key":"2026071003151055000_2026.07.01.735930v1.18","unstructured":"Core, R. (2022). R: A language and environment for statistical computing. https:\/\/www.r-project.org"},{"key":"2026071003151055000_2026.07.01.735930v1.19","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu5905"},{"key":"2026071003151055000_2026.07.01.735930v1.20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200255"},{"key":"2026071003151055000_2026.07.01.735930v1.21","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344219"},{"key":"2026071003151055000_2026.07.01.735930v1.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013635"},{"key":"2026071003151055000_2026.07.01.735930v1.23","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1744-1753.2005"},{"key":"2026071003151055000_2026.07.01.735930v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107559"},{"key":"2026071003151055000_2026.07.01.735930v1.25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"2026071003151055000_2026.07.01.735930v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60255-w"},{"key":"2026071003151055000_2026.07.01.735930v1.27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092315"},{"key":"2026071003151055000_2026.07.01.735930v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30308-3"},{"key":"2026071003151055000_2026.07.01.735930v1.29","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20250161"},{"key":"2026071003151055000_2026.07.01.735930v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.038"},{"key":"2026071003151055000_2026.07.01.735930v1.31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"2026071003151055000_2026.07.01.735930v1.32","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6518"},{"key":"2026071003151055000_2026.07.01.735930v1.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003569"},{"key":"2026071003151055000_2026.07.01.735930v1.34","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67290"},{"key":"2026071003151055000_2026.07.01.735930v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0578-3"},{"key":"2026071003151055000_2026.07.01.735930v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.031"},{"key":"2026071003151055000_2026.07.01.735930v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.062"},{"key":"2026071003151055000_2026.07.01.735930v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.04.004"},{"key":"2026071003151055000_2026.07.01.735930v1.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109157"},{"key":"2026071003151055000_2026.07.01.735930v1.40","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2351"},{"key":"2026071003151055000_2026.07.01.735930v1.41","doi-asserted-by":"publisher","DOI":"10.1101\/060012"},{"key":"2026071003151055000_2026.07.01.735930v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.002"},{"key":"2026071003151055000_2026.07.01.735930v1.43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.150227197"},{"issue":"4","key":"2026071003151055000_2026.07.01.735930v1.44","first-page":"618","article-title":"T-helper 1-like subset selection in Mycobacterium bovis bacillus Calmette-Guerin-infected resistant and susceptible mice","volume":"81","year":"1994","journal-title":"Immunology"},{"key":"2026071003151055000_2026.07.01.735930v1.45","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03496-22"},{"key":"2026071003151055000_2026.07.01.735930v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.004"},{"key":"2026071003151055000_2026.07.01.735930v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-024-00171-0"},{"key":"2026071003151055000_2026.07.01.735930v1.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216922110"},{"key":"2026071003151055000_2026.07.01.735930v1.49","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adn0136"},{"key":"2026071003151055000_2026.07.01.735930v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"2026071003151055000_2026.07.01.735930v1.51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176828"},{"key":"2026071003151055000_2026.07.01.735930v1.52","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026071003151055000_2026.07.01.735930v1.53","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623100517"},{"key":"2026071003151055000_2026.07.01.735930v1.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5243"},{"key":"2026071003151055000_2026.07.01.735930v1.55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028669"},{"key":"2026071003151055000_2026.07.01.735930v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.51"},{"key":"2026071003151055000_2026.07.01.735930v1.57","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2005.25.694"},{"key":"2026071003151055000_2026.07.01.735930v1.58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904189"},{"key":"2026071003151055000_2026.07.01.735930v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-026-02431-8"},{"key":"2026071003151055000_2026.07.01.735930v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01121-x"},{"key":"2026071003151055000_2026.07.01.735930v1.61","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401088"},{"key":"2026071003151055000_2026.07.01.735930v1.62","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180325"},{"key":"2026071003151055000_2026.07.01.735930v1.63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600584"},{"key":"2026071003151055000_2026.07.01.735930v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19412-6"},{"key":"2026071003151055000_2026.07.01.735930v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2025.11.003"},{"key":"2026071003151055000_2026.07.01.735930v1.66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110919"},{"key":"2026071003151055000_2026.07.01.735930v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.09.010"},{"key":"2026071003151055000_2026.07.01.735930v1.68","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095939"},{"key":"2026071003151055000_2026.07.01.735930v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.76"},{"key":"2026071003151055000_2026.07.01.735930v1.70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148548"},{"key":"2026071003151055000_2026.07.01.735930v1.71","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081075"},{"key":"2026071003151055000_2026.07.01.735930v1.72","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac326"},{"key":"2026071003151055000_2026.07.01.735930v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-024-00092-7"},{"key":"2026071003151055000_2026.07.01.735930v1.74","doi-asserted-by":"publisher","DOI":"10.1101\/2025.09.26.678671"},{"key":"2026071003151055000_2026.07.01.735930v1.75","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12210"},{"key":"2026071003151055000_2026.07.01.735930v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05194-y"},{"key":"2026071003151055000_2026.07.01.735930v1.77","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01124-3"},{"key":"2026071003151055000_2026.07.01.735930v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115072"},{"key":"2026071003151055000_2026.07.01.735930v1.79","doi-asserted-by":"publisher","DOI":"10.17912\/micropub.biology.000811"},{"key":"2026071003151055000_2026.07.01.735930v1.80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006687"},{"key":"2026071003151055000_2026.07.01.735930v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.036"},{"key":"2026071003151055000_2026.07.01.735930v1.82","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-72874-y"},{"key":"2026071003151055000_2026.07.01.735930v1.83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20241571"},{"key":"2026071003151055000_2026.07.01.735930v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.049"},{"key":"2026071003151055000_2026.07.01.735930v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2018.02.003"},{"key":"2026071003151055000_2026.07.01.735930v1.86","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233665"},{"key":"2026071003151055000_2026.07.01.735930v1.87","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb05375f"},{"key":"2026071003151055000_2026.07.01.735930v1.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102508"},{"key":"2026071003151055000_2026.07.01.735930v1.89","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.7.897"},{"key":"2026071003151055000_2026.07.01.735930v1.90","unstructured":"WHO. (2024). The WHO Global tuberculosis report. https:\/\/worldhealthorg.shinyapps.io\/TBrief\/?_inputs_&sidebarItemExpanded=null&sidebarCollapsed=true&iso3=%22AFG%22&entity_type=%22group%22"},{"key":"2026071003151055000_2026.07.01.735930v1.91","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw519"},{"key":"2026071003151055000_2026.07.01.735930v1.92","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09152-2"},{"key":"2026071003151055000_2026.07.01.735930v1.93","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18735"},{"key":"2026071003151055000_2026.07.01.735930v1.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101241"},{"key":"2026071003151055000_2026.07.01.735930v1.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2025.103984"},{"key":"2026071003151055000_2026.07.01.735930v1.96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013563"},{"key":"2026071003151055000_2026.07.01.735930v1.97","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi3053"},{"key":"2026071003151055000_2026.07.01.735930v1.98","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.106814"},{"key":"2026071003151055000_2026.07.01.735930v1.99","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6919"},{"key":"2026071003151055000_2026.07.01.735930v1.100","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01027-8"},{"key":"2026071003151055000_2026.07.01.735930v1.101","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.06.680719"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.07.01.735930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:15:19Z","timestamp":1783678519000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.07.01.735930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":101,"URL":"https:\/\/doi.org\/10.64898\/2026.07.01.735930","relation":{},"subject":[],"published":{"date-parts":[[2026,7,7]]},"subtype":"preprint"}}