{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:06:53Z","timestamp":1788991613242,"version":"build-2803163510"},"posted":{"date-parts":[[2026,7,3]]},"group-title":"Molecular Biology","reference-count":104,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Precise regulation of\n                  <jats:italic>Drosophila Myc<\/jats:italic>\n                  is essential for growth and homeostasis, yet regulation of its transcriptional control remains incompletely understood. We investigated the\n                  <jats:italic>Myc cis<\/jats:italic>\n                  -regulatory landscape using\n                  <jats:italic>in vivo<\/jats:italic>\n                  reporter assays, EMSA, and LC-MS\/MS\u2013based identification of DNA-associated proteins. By truncating\n                  <jats:italic>Myc cis<\/jats:italic>\n                  -regulatory modules (CRMs), we delineated the activity of conserved non-coding elements across adult female tissues and larval stages. Specific DNA-protein interactions were confirmed by EMSA using nuclear embryonic extracts. We developed a Solid Surface Magnetic Enrichment protocol (SSMEP) to pull down DNA-protein complexes formed on\n                  <jats:italic>Myc cis<\/jats:italic>\n                  -elements. Affinity purification followed by LC-MS\/MS enabled the identification of candidate transcriptional regulators associated with Myc-CRMs. This integrative approach provides new insights into promoter structure and trans-regulatory architecture of\n                  <jats:italic>Myc<\/jats:italic>\n                  and their roles in developmental gene expression programs. Our study identifies a distal enhancer required for larval and pupal patterning, with activation dependent on specific spacing relative to the TATA-box core promoter, a strong enhancer cluster within 5\u2032-UTR\n                  <jats:italic>cis<\/jats:italic>\n                  -elements active in ovaries and embryos, and a DPE-core promoter requiring nearby enhancer action. The DPE-linked enhancer can function with both Inr\u2013DPE and TATA-box promoters.The identified Myc-CRMs interact with conserved signaling pathways to tightly control\n                  <jats:italic>Myc<\/jats:italic>\n                  during development.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Graphical Abstract<\/jats:title>\n                  <jats:fig id=\"ufig1\" position=\"float\" orientation=\"portrait\" fig-type=\"figure\">\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"736081v2_ufig1\" position=\"float\" orientation=\"portrait\"\/>\n                  <\/jats:fig>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>\n                        <jats:italic>Myc<\/jats:italic>\n                        Oocyte Element: an eRNA-producing enhancer in ovaries and early embryos\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>\n                        DPE promoter synergizes with nearby enhancer to drive\n                        <jats:italic>Drosophila Myc<\/jats:italic>\n                        transcription\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>\n                        Late enhancer licenses TATA promoter for larval tissue-specific\n                        <jats:italic>Myc<\/jats:italic>\n                        transcription\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>\n                        Promoter-enhancer dynamics differentially drive\n                        <jats:italic>Myc<\/jats:italic>\n                        during development\n                      <\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>SSMEP protocol helps purify and enrich low-abundance DNA-protein complexes<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.07.02.736081","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:10:27Z","timestamp":1783073427000},"source":"Crossref","is-referenced-by-count":0,"title":["Functional dissection of\n                  <i>Drosophila Myc cis<\/i>\n                  -regulatory modules (Myc-CRMs) reveals developmentally active DNA-protein 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