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We establish the dynein-microtubule (MT) force-transmission axis as an essential mechanism for nuclear translocation during confined T cell migration and transmigration. We argue that dynein acts both as a motor and as an F-actin-anchored force-transmission element (fulcrum), sliding MTs and the MT-coupled nucleus along the cell cortex to drive nucleokinesis and productive cell displacement. Dynein is the primary driver of nucleokinesis: its inhibition arrests nucleus movement independently of myosin II activity, while F-actin dynamics remain spatiotemporally decoupled from nuclear oscillations. During transmigration, dynein and actomyosin act cooperatively and non-redundantly, and only combined inhibition abolishes nuclear passage. Computational modeling demonstrates that dynein-mediated pulling, together with volume exclusion imposed by the nucleus, is sufficient to generate self-organized nuclear oscillations. Dynein inhibition in zebrafish Langerhans cells impairs protrusion dynamics\n                  <jats:italic>in situ<\/jats:italic>\n                  , identifying the dynein-MT axis as an evolutionarily conserved mechanobiological program. Collectively, these findings identify the dynein-MT mechanical unit as a potential target for engineering T cells with enhanced solid-tumor infiltration.\n                <\/jats:p>","DOI":"10.64898\/2026.07.02.736211","type":"posted-content","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:25:13Z","timestamp":1783106713000},"source":"Crossref","is-referenced-by-count":0,"title":["Dynein-microtubule forces drive nucleokinesis and transmigration in T cells"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-2941","authenticated-orcid":false,"given":"Yerbol","family":"Tagay","sequence":"first","affiliation":[{"name":"Department of Cell and Biological Systems, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, USA"},{"name":"Section on Mechanobiology, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-4953","authenticated-orcid":false,"given":"Alexander S.","family":"Zhovmer","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Cell and Biological Systems, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9850-6303","authenticated-orcid":false,"given":"Jorik","family":"Stoop","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Su","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Fleszar","sequence":"additional","affiliation":[{"name":"Section on Mechanobiology, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Peterman","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA, USA"},{"name":"Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-2499","authenticated-orcid":false,"given":"Alexander X.","family":"Cartagena-Rivera","sequence":"additional","affiliation":[{"name":"Section on Mechanobiology, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-3584","authenticated-orcid":false,"given":"Denis","family":"Tsygankov","sequence":"additional","affiliation":[{"name":"Wallace H. 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