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In some pathogens, bacterial chemosensory zinc-binding (CZB) proteins mediate responses to inflammatory ROS that may contribute to pathogenesis, but their functions in the many environmental bacteria that also possess them remain unclear. Reports of attraction to hypochlorous acid (HOCl), repulsion from hydroperoxides (ROOH) and other ROS, and responsiveness to exogenous zinc have left unresolved whether CZBs distinguish individual effectors or reflect an underlying sensory logic. Here, using time-resolved video microscopy to directly visualize swimming and taxis behaviors, we show that the CZB-containing receptor McpA in\n                  <jats:italic>Salmonella<\/jats:italic>\n                  Typhimurium mediates attraction to O\u2082 and biologically relevant concentrations of HOCl, H\n                  <jats:sub>2<\/jats:sub>\n                  O\n                  <jats:sub>2<\/jats:sub>\n                  , and organic hydroperoxides, three types of oxidants generated through the neutrophil oxidative burst. This identifies the CZB domain as a previously unrecognized sensory architecture for aerotaxis, distinct from, and possibly more widespread, than the FAD-dependent Aer and heme-dependent HemAT and Aer2 families. Although Zn\n                  <jats:sup>2+<\/jats:sup>\n                  itself is not redox-active, we show that McpA-dependent taxis is controlled by Zn\n                  <jats:sup>2+<\/jats:sup>\n                  availability and that exogenous OZn\n                  <jats:sub>2<\/jats:sub>\n                  and ROS promote the formation of insoluble zinc precipitates, which may generate Zn\n                  <jats:sup>2+<\/jats:sup>\n                  gradients sensed through the CZB domain. We propose these findings are consistent with a model in which CZBs use soluble, bioavailable Zn\n                  <jats:sup>2+<\/jats:sup>\n                  as a secondary messenger for highly sensitive navigation of environmental redox landscapes.\n                <\/jats:p>","DOI":"10.64898\/2026.07.03.735341","type":"posted-content","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:04:37Z","timestamp":1783436677000},"source":"Crossref","is-referenced-by-count":1,"title":["The chemoreceptor McpA mediates aerotaxis and redox taxis in\n                  <i>Salmonella<\/i>\n                  Typhimurium"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-225X","authenticated-orcid":false,"given":"Kailie","family":"Franco","sequence":"first","affiliation":[{"name":"Washington State University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-2610","authenticated-orcid":false,"given":"Kendal","family":"Cooper","sequence":"additional","affiliation":[{"name":"NIAID Rocky Mountain Laboratories"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Hyunyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"Washington State University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-4217","authenticated-orcid":false,"given":"Olivia","family":"Steele-Mortimer","sequence":"additional","affiliation":[{"name":"NIAID Rocky Mountain Laboratories"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-769X","authenticated-orcid":false,"given":"Arden","family":"Baylink","sequence":"additional","affiliation":[{"name":"Washington State University;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026071006301761000_2026.07.03.735341v1.1","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1038\/s41467-021-23286-7","article-title":"The Great Oxygenation Event as a consequence of ecological dynamics modulated by planetary change","volume":"12","year":"2021","journal-title":"Nat Commun"},{"key":"2026071006301761000_2026.07.03.735341v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13068"},{"key":"2026071006301761000_2026.07.03.735341v1.3","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S275595"},{"key":"2026071006301761000_2026.07.03.735341v1.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902093200606"},{"key":"2026071006301761000_2026.07.03.735341v1.5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32288"},{"key":"2026071006301761000_2026.07.03.735341v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00456-z"},{"key":"2026071006301761000_2026.07.03.735341v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.05.001"},{"key":"2026071006301761000_2026.07.03.735341v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00730-2"},{"key":"2026071006301761000_2026.07.03.735341v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00456-z"},{"key":"2026071006301761000_2026.07.03.735341v1.10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","year":"2022","journal-title":"Nat Metab"},{"key":"2026071006301761000_2026.07.03.735341v1.11","doi-asserted-by":"crossref","unstructured":"A. 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